Urinary prostaglandin excretion in pregnancy: the effect of dietary sodium restriction
Introduction: Dietary sodium restriction results in activation of the renin-angiotensin-aldosterone-system. In the non-pregnant situation renin release in response to a low sodium diet is mediated by prostaglandins. We studied the effect of dietary sodium restriction on urinary prostaglandin metabol...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2000-10, Vol.63 (4), p.209-215 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | Delemarre, F.M.C. Thomas, C.M.G. van den Berg, R.J. Jongsma, H.W. Steegers, E.A.P. |
| description | Introduction: Dietary sodium restriction results in activation of the renin-angiotensin-aldosterone-system. In the non-pregnant situation renin release in response to a low sodium diet is mediated by prostaglandins. We studied the effect of dietary sodium restriction on urinary prostaglandin metabolism in pregnancy.
Patients and methods: In a randomized, longitudinal study the excretion of urinary metabolites of prostacyclin (6-keto-PGF1 αand 2,3-dinor-6-keto-PGF1 α) and thromboxane A2(TxB2and 2,3-dinor-TxB2) was determined throughout pregnancy and post partum in 12 women on a low sodium diet and in 12 controls.
Results: In pregnancy the excretion of all urinary prostaglandins is increased. The 6-keto-PGF1 α/ TxB2-ratio as well as the 2,3-dinor-6-keto-PGF1α/ 2,3-dinor-TxB2-ratio did not significantly change in pregnancy.
Conclusion:Prostacyclin and thromboxane do not seem to play an important role in sodium balance during pregnancy. |
| doi_str_mv | 10.1054/plef.2000.0211 |
| format | Article |
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Patients and methods: In a randomized, longitudinal study the excretion of urinary metabolites of prostacyclin (6-keto-PGF1 αand 2,3-dinor-6-keto-PGF1 α) and thromboxane A2(TxB2and 2,3-dinor-TxB2) was determined throughout pregnancy and post partum in 12 women on a low sodium diet and in 12 controls.
Results: In pregnancy the excretion of all urinary prostaglandins is increased. The 6-keto-PGF1 α/ TxB2-ratio as well as the 2,3-dinor-6-keto-PGF1α/ 2,3-dinor-TxB2-ratio did not significantly change in pregnancy.
Conclusion:Prostacyclin and thromboxane do not seem to play an important role in sodium balance during pregnancy.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1054/plef.2000.0211</identifier><identifier>PMID: 11049696</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>6-Ketoprostaglandin F1 alpha - analogs & derivatives ; 6-Ketoprostaglandin F1 alpha - urine ; Adult ; Biological and medical sciences ; Creatinine - urine ; Diet, Sodium-Restricted ; Epoprostenol - urine ; Female ; Fundamental and applied biological sciences. Psychology ; Hormone metabolism and regulation ; Humans ; Hypertension - diet therapy ; Hypertension - metabolism ; Hypertension - urine ; Longitudinal Studies ; Postpartum Period ; Pregnancy - metabolism ; Pregnancy - urine ; Pregnancy. Parturition. Lactation ; Prostaglandins - metabolism ; Prostaglandins - urine ; Random Allocation ; Sodium - urine ; Thromboxane A2 - metabolism ; Thromboxane B2 - analogs & derivatives ; Thromboxane B2 - urine ; Vertebrates: reproduction ; Water-Electrolyte Balance</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 2000-10, Vol.63 (4), p.209-215</ispartof><rights>2000 Harcourt Publishers Ltd</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2000 Harcourt Publishers Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-5141bedf4abbae8c575408b7cad252037e6e80ec52d4e00b41f74d05f1902f233</citedby><cites>FETCH-LOGICAL-c368t-5141bedf4abbae8c575408b7cad252037e6e80ec52d4e00b41f74d05f1902f233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0952327800902114$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=851240$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11049696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delemarre, F.M.C.</creatorcontrib><creatorcontrib>Thomas, C.M.G.</creatorcontrib><creatorcontrib>van den Berg, R.J.</creatorcontrib><creatorcontrib>Jongsma, H.W.</creatorcontrib><creatorcontrib>Steegers, E.A.P.</creatorcontrib><title>Urinary prostaglandin excretion in pregnancy: the effect of dietary sodium restriction</title><title>Prostaglandins, leukotrienes and essential fatty acids</title><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><description>Introduction: Dietary sodium restriction results in activation of the renin-angiotensin-aldosterone-system. In the non-pregnant situation renin release in response to a low sodium diet is mediated by prostaglandins. We studied the effect of dietary sodium restriction on urinary prostaglandin metabolism in pregnancy.
Patients and methods: In a randomized, longitudinal study the excretion of urinary metabolites of prostacyclin (6-keto-PGF1 αand 2,3-dinor-6-keto-PGF1 α) and thromboxane A2(TxB2and 2,3-dinor-TxB2) was determined throughout pregnancy and post partum in 12 women on a low sodium diet and in 12 controls.
Results: In pregnancy the excretion of all urinary prostaglandins is increased. The 6-keto-PGF1 α/ TxB2-ratio as well as the 2,3-dinor-6-keto-PGF1α/ 2,3-dinor-TxB2-ratio did not significantly change in pregnancy.
Conclusion:Prostacyclin and thromboxane do not seem to play an important role in sodium balance during pregnancy.</description><subject>6-Ketoprostaglandin F1 alpha - analogs & derivatives</subject><subject>6-Ketoprostaglandin F1 alpha - urine</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Creatinine - urine</subject><subject>Diet, Sodium-Restricted</subject><subject>Epoprostenol - urine</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone metabolism and regulation</subject><subject>Humans</subject><subject>Hypertension - diet therapy</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - urine</subject><subject>Longitudinal Studies</subject><subject>Postpartum Period</subject><subject>Pregnancy - metabolism</subject><subject>Pregnancy - urine</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Prostaglandins - metabolism</subject><subject>Prostaglandins - urine</subject><subject>Random Allocation</subject><subject>Sodium - urine</subject><subject>Thromboxane A2 - metabolism</subject><subject>Thromboxane B2 - analogs & derivatives</subject><subject>Thromboxane B2 - urine</subject><subject>Vertebrates: reproduction</subject><subject>Water-Electrolyte Balance</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMoWqtXj7IgeNs6ySa7W29S_IKCF-s1ZJNJjexHTbZi_71ZuujJUxh43sk7DyEXFGYUBL_Z1GhnDABmwCg9IBMqMpaykmWHZAJzwdKMFeUJOQ3hI1KR4cfkhFLg83yeT8jbyrtW-V2y8V3o1bpWrXFtgt_aY--6NonDxuO6Va3e3Sb9OyZoLeo-6WxiHPZDNnTGbZvEY-i900PsjBxZVQc8H98pWT3cvy6e0uXL4_PibpnqLC_7VFBOKzSWq6pSWGpRCA5lVWhlmGCQFZhjCagFMxwBKk5twQ0IS-fALMuyKbne7431P7fxf9m4oLGOZ2C3DbJgWc4KziM424M63hk8WrnxronlJQU5mJSDSTmYlIOlGLgcN2-rBs0fPqqLwNUIqKBVbX005MIvVwrKOESq3FMYLXw59DJoh61G43y0KE3n_mvwA9NXj9E</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Delemarre, F.M.C.</creator><creator>Thomas, C.M.G.</creator><creator>van den Berg, R.J.</creator><creator>Jongsma, H.W.</creator><creator>Steegers, E.A.P.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Urinary prostaglandin excretion in pregnancy: the effect of dietary sodium restriction</title><author>Delemarre, F.M.C. ; Thomas, C.M.G. ; van den Berg, R.J. ; Jongsma, H.W. ; Steegers, E.A.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-5141bedf4abbae8c575408b7cad252037e6e80ec52d4e00b41f74d05f1902f233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>6-Ketoprostaglandin F1 alpha - analogs & derivatives</topic><topic>6-Ketoprostaglandin F1 alpha - urine</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Creatinine - urine</topic><topic>Diet, Sodium-Restricted</topic><topic>Epoprostenol - urine</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone metabolism and regulation</topic><topic>Humans</topic><topic>Hypertension - diet therapy</topic><topic>Hypertension - metabolism</topic><topic>Hypertension - urine</topic><topic>Longitudinal Studies</topic><topic>Postpartum Period</topic><topic>Pregnancy - metabolism</topic><topic>Pregnancy - urine</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Prostaglandins - metabolism</topic><topic>Prostaglandins - urine</topic><topic>Random Allocation</topic><topic>Sodium - urine</topic><topic>Thromboxane A2 - metabolism</topic><topic>Thromboxane B2 - analogs & derivatives</topic><topic>Thromboxane B2 - urine</topic><topic>Vertebrates: reproduction</topic><topic>Water-Electrolyte Balance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delemarre, F.M.C.</creatorcontrib><creatorcontrib>Thomas, C.M.G.</creatorcontrib><creatorcontrib>van den Berg, R.J.</creatorcontrib><creatorcontrib>Jongsma, H.W.</creatorcontrib><creatorcontrib>Steegers, E.A.P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delemarre, F.M.C.</au><au>Thomas, C.M.G.</au><au>van den Berg, R.J.</au><au>Jongsma, H.W.</au><au>Steegers, E.A.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary prostaglandin excretion in pregnancy: the effect of dietary sodium restriction</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>63</volume><issue>4</issue><spage>209</spage><epage>215</epage><pages>209-215</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>Introduction: Dietary sodium restriction results in activation of the renin-angiotensin-aldosterone-system. In the non-pregnant situation renin release in response to a low sodium diet is mediated by prostaglandins. We studied the effect of dietary sodium restriction on urinary prostaglandin metabolism in pregnancy.
Patients and methods: In a randomized, longitudinal study the excretion of urinary metabolites of prostacyclin (6-keto-PGF1 αand 2,3-dinor-6-keto-PGF1 α) and thromboxane A2(TxB2and 2,3-dinor-TxB2) was determined throughout pregnancy and post partum in 12 women on a low sodium diet and in 12 controls.
Results: In pregnancy the excretion of all urinary prostaglandins is increased. The 6-keto-PGF1 α/ TxB2-ratio as well as the 2,3-dinor-6-keto-PGF1α/ 2,3-dinor-TxB2-ratio did not significantly change in pregnancy.
Conclusion:Prostacyclin and thromboxane do not seem to play an important role in sodium balance during pregnancy.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>11049696</pmid><doi>10.1054/plef.2000.0211</doi><tpages>7</tpages></addata></record> |
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| subjects | 6-Ketoprostaglandin F1 alpha - analogs & derivatives 6-Ketoprostaglandin F1 alpha - urine Adult Biological and medical sciences Creatinine - urine Diet, Sodium-Restricted Epoprostenol - urine Female Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans Hypertension - diet therapy Hypertension - metabolism Hypertension - urine Longitudinal Studies Postpartum Period Pregnancy - metabolism Pregnancy - urine Pregnancy. Parturition. Lactation Prostaglandins - metabolism Prostaglandins - urine Random Allocation Sodium - urine Thromboxane A2 - metabolism Thromboxane B2 - analogs & derivatives Thromboxane B2 - urine Vertebrates: reproduction Water-Electrolyte Balance |
| title | Urinary prostaglandin excretion in pregnancy: the effect of dietary sodium restriction |
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