Does the shared epitope genotype influence either the susceptibility to or the phenotype of corneal melting?
Purpose To investigate the role of the shared epitope alleles in determining susceptibility to and the phenotype of corneal melting in patients with rheumatoid arthritis (RA). Methods The HLA class 1 and 2 genotype was determined for 17 patients with rheumatoid-associated corneal melting by the phot...
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| Veröffentlicht in: | Eye (London) 2001-08, Vol.15 (4), p.492-496 |
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| creator | McKibbin, M Clark, B Isaacs, J D Morrell, A J Griffiths, B Morgan, A W Gooi, H C |
| description | Purpose
To investigate the role of the shared epitope alleles in determining susceptibility to and the phenotype of corneal melting in patients with rheumatoid arthritis (RA).
Methods
The HLA class 1 and 2 genotype was determined for 17 patients with rheumatoid-associated corneal melting by the phototyping method. HLA-DR4 subtyping was performed by PCR sequence-based typing. The frequency of all the shared epitope alleles and, in particular, of the higher-risk *0401 and *0404 alleles, was compared with healthy controls and unrelated RA patients, with and without extra-articular manifestations. A comparison was also made between the shared epitope genotype of the corneal melt patients and local, ocular disease characteristics.
Results
Thirteen (76%) patients with corneal melt possessed at least one shared epitope allele and 5 (29%) possessed two alleles. The dominant alleles were variants of the DR4 family, notably the *0401, *0404 and *0408 alleles. Both the allele frequency and a double dose of shared epitope alleles were more common in the three RA patient groups than in the healthy, control group
(p
< 0.005). Although the frequency of the higher-risk alleles was similar in the three RA patient group, a trend existed for a double dose of higher-risk alleles to be more common in the patients with either corneal melt or other extra-articular manifestations
(p
> 0.2). No association was found between the number or type of shared epitope alleles and any of the ocular disease characteristics studied.
Conclusions
The results of this study suggest that the shared epitope alleles do not influence the ocular disease phenotype of corneal melt in RA patients. Shared epitope determination of RA patients may help to identify those susceptible to either corneal melt or other extra-articular disease. RA patients with a double dose of higher-risk alleles may have an increased risk of corneal melt. |
| doi_str_mv | 10.1038/eye.2001.161 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72362149</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72362149</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-66715ff70c66b3932a9ae755f057c1b595625dbdab4a967eddaa8120f92257153</originalsourceid><addsrcrecordid>eNp10MFvFCEUBnDSaOy2euvZcDCenBWYAXZOjalWTZp4aRNvhGEeuzQsTIE57H8vm9lWL54geb_3QT6ErihZU9JuPsMB1owQuqaCnqEV7aRoeMe7V2hFek4axtjvc3SR82NFnZTkDTqnVApJGF8h_zVCxmUHOO90ghHD5EqcAG8hxHKoFxesnyEYwOCqSwues4GpuMF5Vw64RByXwbR73osWm5gCaI_34IsL2-u36LXVPsO703mJHm6_3d_8aO5-ff958-WuMR2VpRFCUm6tJEaIoe1bpnsNknNLuDR04D0XjI_DqIdO90LCOGq9oYzYnjFeV9tL9HHJnVJ8miEXtXf1v97rAHHOSrJWMNr1FX5aoEkx5wRWTcntdTooStSxXVXbVcd2VW238ven3HnYw_gXn-qs4MMJ6Gy0t0kH4_I_oRsie1ZZs7BcJ2ELST3GOYVayf_exYsPuswJXvIqOpoj-QNXxp1E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72362149</pqid></control><display><type>article</type><title>Does the shared epitope genotype influence either the susceptibility to or the phenotype of corneal melting?</title><source>MEDLINE</source><source>SpringerNature Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>McKibbin, M ; Clark, B ; Isaacs, J D ; Morrell, A J ; Griffiths, B ; Morgan, A W ; Gooi, H C</creator><creatorcontrib>McKibbin, M ; Clark, B ; Isaacs, J D ; Morrell, A J ; Griffiths, B ; Morgan, A W ; Gooi, H C</creatorcontrib><description>Purpose
To investigate the role of the shared epitope alleles in determining susceptibility to and the phenotype of corneal melting in patients with rheumatoid arthritis (RA).
Methods
The HLA class 1 and 2 genotype was determined for 17 patients with rheumatoid-associated corneal melting by the phototyping method. HLA-DR4 subtyping was performed by PCR sequence-based typing. The frequency of all the shared epitope alleles and, in particular, of the higher-risk *0401 and *0404 alleles, was compared with healthy controls and unrelated RA patients, with and without extra-articular manifestations. A comparison was also made between the shared epitope genotype of the corneal melt patients and local, ocular disease characteristics.
Results
Thirteen (76%) patients with corneal melt possessed at least one shared epitope allele and 5 (29%) possessed two alleles. The dominant alleles were variants of the DR4 family, notably the *0401, *0404 and *0408 alleles. Both the allele frequency and a double dose of shared epitope alleles were more common in the three RA patient groups than in the healthy, control group
(p
< 0.005). Although the frequency of the higher-risk alleles was similar in the three RA patient group, a trend existed for a double dose of higher-risk alleles to be more common in the patients with either corneal melt or other extra-articular manifestations
(p
> 0.2). No association was found between the number or type of shared epitope alleles and any of the ocular disease characteristics studied.
Conclusions
The results of this study suggest that the shared epitope alleles do not influence the ocular disease phenotype of corneal melt in RA patients. Shared epitope determination of RA patients may help to identify those susceptible to either corneal melt or other extra-articular disease. RA patients with a double dose of higher-risk alleles may have an increased risk of corneal melt.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/eye.2001.161</identifier><identifier>PMID: 11767025</identifier><identifier>CODEN: EYEEEC</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Alleles ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - immunology ; Biological and medical sciences ; clinical-study ; Corneal Ulcer - etiology ; Corneal Ulcer - genetics ; Corneal Ulcer - immunology ; Female ; Genetic Predisposition to Disease ; Genotype ; Histocompatibility Testing ; HLA-DR4 Antigen - genetics ; Humans ; Laboratory Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Miscellaneous ; Ophthalmology ; Pharmaceutical Sciences/Technology ; Phenotype ; Surgery ; Surgical Oncology</subject><ispartof>Eye (London), 2001-08, Vol.15 (4), p.492-496</ispartof><rights>Royal College of Ophthalmologists 2001</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-66715ff70c66b3932a9ae755f057c1b595625dbdab4a967eddaa8120f92257153</citedby><cites>FETCH-LOGICAL-c417t-66715ff70c66b3932a9ae755f057c1b595625dbdab4a967eddaa8120f92257153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/eye.2001.161$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/eye.2001.161$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1080792$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11767025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McKibbin, M</creatorcontrib><creatorcontrib>Clark, B</creatorcontrib><creatorcontrib>Isaacs, J D</creatorcontrib><creatorcontrib>Morrell, A J</creatorcontrib><creatorcontrib>Griffiths, B</creatorcontrib><creatorcontrib>Morgan, A W</creatorcontrib><creatorcontrib>Gooi, H C</creatorcontrib><title>Does the shared epitope genotype influence either the susceptibility to or the phenotype of corneal melting?</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Purpose
To investigate the role of the shared epitope alleles in determining susceptibility to and the phenotype of corneal melting in patients with rheumatoid arthritis (RA).
Methods
The HLA class 1 and 2 genotype was determined for 17 patients with rheumatoid-associated corneal melting by the phototyping method. HLA-DR4 subtyping was performed by PCR sequence-based typing. The frequency of all the shared epitope alleles and, in particular, of the higher-risk *0401 and *0404 alleles, was compared with healthy controls and unrelated RA patients, with and without extra-articular manifestations. A comparison was also made between the shared epitope genotype of the corneal melt patients and local, ocular disease characteristics.
Results
Thirteen (76%) patients with corneal melt possessed at least one shared epitope allele and 5 (29%) possessed two alleles. The dominant alleles were variants of the DR4 family, notably the *0401, *0404 and *0408 alleles. Both the allele frequency and a double dose of shared epitope alleles were more common in the three RA patient groups than in the healthy, control group
(p
< 0.005). Although the frequency of the higher-risk alleles was similar in the three RA patient group, a trend existed for a double dose of higher-risk alleles to be more common in the patients with either corneal melt or other extra-articular manifestations
(p
> 0.2). No association was found between the number or type of shared epitope alleles and any of the ocular disease characteristics studied.
Conclusions
The results of this study suggest that the shared epitope alleles do not influence the ocular disease phenotype of corneal melt in RA patients. Shared epitope determination of RA patients may help to identify those susceptible to either corneal melt or other extra-articular disease. RA patients with a double dose of higher-risk alleles may have an increased risk of corneal melt.</description><subject>Alleles</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Biological and medical sciences</subject><subject>clinical-study</subject><subject>Corneal Ulcer - etiology</subject><subject>Corneal Ulcer - genetics</subject><subject>Corneal Ulcer - immunology</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Histocompatibility Testing</subject><subject>HLA-DR4 Antigen - genetics</subject><subject>Humans</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Miscellaneous</subject><subject>Ophthalmology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Phenotype</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MFvFCEUBnDSaOy2euvZcDCenBWYAXZOjalWTZp4aRNvhGEeuzQsTIE57H8vm9lWL54geb_3QT6ErihZU9JuPsMB1owQuqaCnqEV7aRoeMe7V2hFek4axtjvc3SR82NFnZTkDTqnVApJGF8h_zVCxmUHOO90ghHD5EqcAG8hxHKoFxesnyEYwOCqSwues4GpuMF5Vw64RByXwbR73osWm5gCaI_34IsL2-u36LXVPsO703mJHm6_3d_8aO5-ff958-WuMR2VpRFCUm6tJEaIoe1bpnsNknNLuDR04D0XjI_DqIdO90LCOGq9oYzYnjFeV9tL9HHJnVJ8miEXtXf1v97rAHHOSrJWMNr1FX5aoEkx5wRWTcntdTooStSxXVXbVcd2VW238ven3HnYw_gXn-qs4MMJ6Gy0t0kH4_I_oRsie1ZZs7BcJ2ELST3GOYVayf_exYsPuswJXvIqOpoj-QNXxp1E</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>McKibbin, M</creator><creator>Clark, B</creator><creator>Isaacs, J D</creator><creator>Morrell, A J</creator><creator>Griffiths, B</creator><creator>Morgan, A W</creator><creator>Gooi, H C</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>Does the shared epitope genotype influence either the susceptibility to or the phenotype of corneal melting?</title><author>McKibbin, M ; Clark, B ; Isaacs, J D ; Morrell, A J ; Griffiths, B ; Morgan, A W ; Gooi, H C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-66715ff70c66b3932a9ae755f057c1b595625dbdab4a967eddaa8120f92257153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Alleles</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Biological and medical sciences</topic><topic>clinical-study</topic><topic>Corneal Ulcer - etiology</topic><topic>Corneal Ulcer - genetics</topic><topic>Corneal Ulcer - immunology</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Histocompatibility Testing</topic><topic>HLA-DR4 Antigen - genetics</topic><topic>Humans</topic><topic>Laboratory Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Miscellaneous</topic><topic>Ophthalmology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Phenotype</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McKibbin, M</creatorcontrib><creatorcontrib>Clark, B</creatorcontrib><creatorcontrib>Isaacs, J D</creatorcontrib><creatorcontrib>Morrell, A J</creatorcontrib><creatorcontrib>Griffiths, B</creatorcontrib><creatorcontrib>Morgan, A W</creatorcontrib><creatorcontrib>Gooi, H C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McKibbin, M</au><au>Clark, B</au><au>Isaacs, J D</au><au>Morrell, A J</au><au>Griffiths, B</au><au>Morgan, A W</au><au>Gooi, H C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does the shared epitope genotype influence either the susceptibility to or the phenotype of corneal melting?</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>15</volume><issue>4</issue><spage>492</spage><epage>496</epage><pages>492-496</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><coden>EYEEEC</coden><abstract>Purpose
To investigate the role of the shared epitope alleles in determining susceptibility to and the phenotype of corneal melting in patients with rheumatoid arthritis (RA).
Methods
The HLA class 1 and 2 genotype was determined for 17 patients with rheumatoid-associated corneal melting by the phototyping method. HLA-DR4 subtyping was performed by PCR sequence-based typing. The frequency of all the shared epitope alleles and, in particular, of the higher-risk *0401 and *0404 alleles, was compared with healthy controls and unrelated RA patients, with and without extra-articular manifestations. A comparison was also made between the shared epitope genotype of the corneal melt patients and local, ocular disease characteristics.
Results
Thirteen (76%) patients with corneal melt possessed at least one shared epitope allele and 5 (29%) possessed two alleles. The dominant alleles were variants of the DR4 family, notably the *0401, *0404 and *0408 alleles. Both the allele frequency and a double dose of shared epitope alleles were more common in the three RA patient groups than in the healthy, control group
(p
< 0.005). Although the frequency of the higher-risk alleles was similar in the three RA patient group, a trend existed for a double dose of higher-risk alleles to be more common in the patients with either corneal melt or other extra-articular manifestations
(p
> 0.2). No association was found between the number or type of shared epitope alleles and any of the ocular disease characteristics studied.
Conclusions
The results of this study suggest that the shared epitope alleles do not influence the ocular disease phenotype of corneal melt in RA patients. Shared epitope determination of RA patients may help to identify those susceptible to either corneal melt or other extra-articular disease. RA patients with a double dose of higher-risk alleles may have an increased risk of corneal melt.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>11767025</pmid><doi>10.1038/eye.2001.161</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Eye (London), 2001-08, Vol.15 (4), p.492-496 |
| issn | 0950-222X 1476-5454 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72362149 |
| source | MEDLINE; SpringerNature Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Alleles Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Biological and medical sciences clinical-study Corneal Ulcer - etiology Corneal Ulcer - genetics Corneal Ulcer - immunology Female Genetic Predisposition to Disease Genotype Histocompatibility Testing HLA-DR4 Antigen - genetics Humans Laboratory Medicine Male Medical sciences Medicine Medicine & Public Health Miscellaneous Ophthalmology Pharmaceutical Sciences/Technology Phenotype Surgery Surgical Oncology |
| title | Does the shared epitope genotype influence either the susceptibility to or the phenotype of corneal melting? |
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