No Significant Correlation Exists Between Core Promoter Mutations, Viral Replication, and Liver Damage in Chronic Hepatitis B Infection

Hepatitis B virus (HBV) core promoter mutants have been proposed to contribute to severe liver damage by increasing viral loads, but this has not yet been clearly shown. To examine the effects of core promoter mutants on viral load and liver damage, we first developed a polymerase chain reaction (PC...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2000-11, Vol.32 (5), p.1154-1162
Hauptverfasser:	Keun Chun, Yoon, Youn Kim, Jee, Jung Woo, Hong, Myung Oh, Soo, Kang, Insug, Ha, Joohun, Soo Kim, Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alanine Transaminase - blood Biological and medical sciences Cells, Cultured DNA, Viral - blood Female Hepatitis B virus - genetics Hepatitis B, Chronic - blood Hepatitis B, Chronic - genetics Hepatitis B, Chronic - pathology Hepatitis B, Chronic - virology Human viral diseases Humans Infectious diseases Liver - pathology Male Medical sciences Middle Aged Mutation Promoter Regions, Genetic - genetics Tropical medicine Viral Core Proteins - genetics Viral diseases Viral hepatitis Virus Replication
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