Ketamine infusion versus isoflurane for the maintenance of anesthesia in the prebypass period in children with tetralogy of fallot
Objective: To evaluate the use of ketamine in comparison with isoflurane in the maintenance of anesthesia in children with tetralogy of Fallot. Design: Prospective, randomized study. Setting: University hospital. Participants: Fifty children scheduled for correction of tetralogy of Fallot. Intervent...
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| Veröffentlicht in: | Journal of cardiothoracic and vascular anesthesia 2000-10, Vol.14 (5), p.557-561 |
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| container_title | Journal of cardiothoracic and vascular anesthesia |
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| creator | Tuğrul, Mehmet Çamci, Emre Pembeci, Kamil Telci, Lütfi Akpir, Kutay |
| description | Objective: To evaluate the use of ketamine in comparison with isoflurane in the maintenance of anesthesia in children with tetralogy of Fallot. Design: Prospective, randomized study. Setting: University hospital. Participants: Fifty children scheduled for correction of tetralogy of Fallot. Interventions: After intubation, patients were assigned randomly to receive 2 different anesthesia maintenance regimens: group I, isoflurane, 0 to 1% plus fentanyl, 0.1 μg/kg/min; group II, ketamine, 0 to 5 mg/kg/h, plus fentanyl, 0.1 μg/kg/min. Isoflurane concentration and ketamine infusion rate were adjusted to maintain arterial pressure within 25% of baseline. Hemodynamic and respiratory parameters were recorded at the end of 4 intervals: T0, before induction of anesthesia; T1, induction to 10 minutes postintubation; T2, 10 minutes postintubation to poststernotomy; and T3, poststernotomy to completion of catheterizations. Measurements and Main Results: In comparing group I with group II, significant differences were observed in mean arterial pressure (p < 0.0001), heart rate (p < 0.01), arterial oxygen saturation (p < 0.0001), arterial oxygen tension (p < 0.001), arterial carbon dioxide tension (p < 0.001), arterial pH (p < 0.0001), base excess (p < 0.05), and arterial to end-tidal carbon dioxide tension difference (p < 0.01) at T3. Conclusion: The use of ketamine anesthesia is recommended as an alternative maintenance regimen in children undergoing definitive correction of tetralogy of Fallot. Copyright © 2000 by W.B. Saunders Company |
| doi_str_mv | 10.1053/jcan.2000.9448 |
| format | Article |
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Design: Prospective, randomized study. Setting: University hospital. Participants: Fifty children scheduled for correction of tetralogy of Fallot. Interventions: After intubation, patients were assigned randomly to receive 2 different anesthesia maintenance regimens: group I, isoflurane, 0 to 1% plus fentanyl, 0.1 μg/kg/min; group II, ketamine, 0 to 5 mg/kg/h, plus fentanyl, 0.1 μg/kg/min. Isoflurane concentration and ketamine infusion rate were adjusted to maintain arterial pressure within 25% of baseline. Hemodynamic and respiratory parameters were recorded at the end of 4 intervals: T0, before induction of anesthesia; T1, induction to 10 minutes postintubation; T2, 10 minutes postintubation to poststernotomy; and T3, poststernotomy to completion of catheterizations. Measurements and Main Results: In comparing group I with group II, significant differences were observed in mean arterial pressure (p < 0.0001), heart rate (p < 0.01), arterial oxygen saturation (p < 0.0001), arterial oxygen tension (p < 0.001), arterial carbon dioxide tension (p < 0.001), arterial pH (p < 0.0001), base excess (p < 0.05), and arterial to end-tidal carbon dioxide tension difference (p < 0.01) at T3. Conclusion: The use of ketamine anesthesia is recommended as an alternative maintenance regimen in children undergoing definitive correction of tetralogy of Fallot. Copyright © 2000 by W.B. Saunders Company]]></description><identifier>ISSN: 1053-0770</identifier><identifier>EISSN: 1532-8422</identifier><identifier>DOI: 10.1053/jcan.2000.9448</identifier><identifier>PMID: 11052438</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Anesthesia ; Anesthesia depending on type of surgery ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; arterial ; Biological and medical sciences ; Carbon Dioxide - blood ; cardiac surgery ; Child ; Child, Preschool ; Dopamine - pharmacology ; Epinephrine - pharmacology ; Hemodynamics - drug effects ; Hemoglobins - analysis ; Humans ; Infant ; intravenous anesthetics ; isoflurane ; Isoflurane - pharmacology ; ketamine ; Ketamine - pharmacology ; Medical sciences ; Oxygen - blood ; oxygenation ; Prospective Studies ; tetralogy of Fallot ; Tetralogy of Fallot - surgery ; Thoracic and cardiovascular surgery. Cardiopulmonary bypass ; volatile anesthetics</subject><ispartof>Journal of cardiothoracic and vascular anesthesia, 2000-10, Vol.14 (5), p.557-561</ispartof><rights>2000 W.B. Saunders Company</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-8bddc4c13beeac6f23cbfac53f3719bebd2edf084b67d240bccea9b980a811f33</citedby><cites>FETCH-LOGICAL-c368t-8bddc4c13beeac6f23cbfac53f3719bebd2edf084b67d240bccea9b980a811f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/jcan.2000.9448$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=817939$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11052438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tuğrul, Mehmet</creatorcontrib><creatorcontrib>Çamci, Emre</creatorcontrib><creatorcontrib>Pembeci, Kamil</creatorcontrib><creatorcontrib>Telci, Lütfi</creatorcontrib><creatorcontrib>Akpir, Kutay</creatorcontrib><title>Ketamine infusion versus isoflurane for the maintenance of anesthesia in the prebypass period in children with tetralogy of fallot</title><title>Journal of cardiothoracic and vascular anesthesia</title><addtitle>J Cardiothorac Vasc Anesth</addtitle><description><![CDATA[Objective: To evaluate the use of ketamine in comparison with isoflurane in the maintenance of anesthesia in children with tetralogy of Fallot. Design: Prospective, randomized study. Setting: University hospital. Participants: Fifty children scheduled for correction of tetralogy of Fallot. Interventions: After intubation, patients were assigned randomly to receive 2 different anesthesia maintenance regimens: group I, isoflurane, 0 to 1% plus fentanyl, 0.1 μg/kg/min; group II, ketamine, 0 to 5 mg/kg/h, plus fentanyl, 0.1 μg/kg/min. Isoflurane concentration and ketamine infusion rate were adjusted to maintain arterial pressure within 25% of baseline. Hemodynamic and respiratory parameters were recorded at the end of 4 intervals: T0, before induction of anesthesia; T1, induction to 10 minutes postintubation; T2, 10 minutes postintubation to poststernotomy; and T3, poststernotomy to completion of catheterizations. Measurements and Main Results: In comparing group I with group II, significant differences were observed in mean arterial pressure (p < 0.0001), heart rate (p < 0.01), arterial oxygen saturation (p < 0.0001), arterial oxygen tension (p < 0.001), arterial carbon dioxide tension (p < 0.001), arterial pH (p < 0.0001), base excess (p < 0.05), and arterial to end-tidal carbon dioxide tension difference (p < 0.01) at T3. Conclusion: The use of ketamine anesthesia is recommended as an alternative maintenance regimen in children undergoing definitive correction of tetralogy of Fallot. Copyright © 2000 by W.B. Saunders Company]]></description><subject>Anesthesia</subject><subject>Anesthesia depending on type of surgery</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>arterial</subject><subject>Biological and medical sciences</subject><subject>Carbon Dioxide - blood</subject><subject>cardiac surgery</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dopamine - pharmacology</subject><subject>Epinephrine - pharmacology</subject><subject>Hemodynamics - drug effects</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Infant</subject><subject>intravenous anesthetics</subject><subject>isoflurane</subject><subject>Isoflurane - pharmacology</subject><subject>ketamine</subject><subject>Ketamine - pharmacology</subject><subject>Medical sciences</subject><subject>Oxygen - blood</subject><subject>oxygenation</subject><subject>Prospective Studies</subject><subject>tetralogy of Fallot</subject><subject>Tetralogy of Fallot - surgery</subject><subject>Thoracic and cardiovascular surgery. Cardiopulmonary bypass</subject><subject>volatile anesthetics</subject><issn>1053-0770</issn><issn>1532-8422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtv1DAQhyMEog-4ckSWkLhl60cezhFVhSIq9QJny48x6yqJg8cp2mv_8jrsCk6cPJrfN6PxV1XvGN0x2oqrB6vnHaeU7oamkS-qc9YKXsuG85elLkRN-56eVReID5Qy1rb96-qMlYQ3Qp5XT98g6ynMQMLsVwxxJo-QcEUSMPpxTbpEPiaS90AmHeYMs54tkOhJibC0Megy_AdYEpjDohHJAilEt_XtPowuwUx-h7wnGXLSY_x52BZ4PY4xv6lelQLh7em9rH58vvl-fVvf3X_5ev3prraik7mWxjnbWCYMgLad58Iar20rvOjZYMA4Ds5T2Ziud7yhxlrQgxkk1ZIxL8Rl9fG4d0nx11pOV1NAC-NY_hFXVD0XHRPdBu6OoE0RMYFXSwqTTgfFqNqcqs262qyrzXoZeH_avJoJ3D_8pLkAH06ARqtHX6zagH85yfpBDIWSRwqKhccASaENUGS7kMBm5WL43wXPwgaiAQ</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Tuğrul, Mehmet</creator><creator>Çamci, Emre</creator><creator>Pembeci, Kamil</creator><creator>Telci, Lütfi</creator><creator>Akpir, Kutay</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Ketamine infusion versus isoflurane for the maintenance of anesthesia in the prebypass period in children with tetralogy of fallot</title><author>Tuğrul, Mehmet ; Çamci, Emre ; Pembeci, Kamil ; Telci, Lütfi ; Akpir, Kutay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-8bddc4c13beeac6f23cbfac53f3719bebd2edf084b67d240bccea9b980a811f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Anesthesia</topic><topic>Anesthesia depending on type of surgery</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>arterial</topic><topic>Biological and medical sciences</topic><topic>Carbon Dioxide - blood</topic><topic>cardiac surgery</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dopamine - pharmacology</topic><topic>Epinephrine - pharmacology</topic><topic>Hemodynamics - drug effects</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Infant</topic><topic>intravenous anesthetics</topic><topic>isoflurane</topic><topic>Isoflurane - pharmacology</topic><topic>ketamine</topic><topic>Ketamine - pharmacology</topic><topic>Medical sciences</topic><topic>Oxygen - blood</topic><topic>oxygenation</topic><topic>Prospective Studies</topic><topic>tetralogy of Fallot</topic><topic>Tetralogy of Fallot - surgery</topic><topic>Thoracic and cardiovascular surgery. Cardiopulmonary bypass</topic><topic>volatile anesthetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tuğrul, Mehmet</creatorcontrib><creatorcontrib>Çamci, Emre</creatorcontrib><creatorcontrib>Pembeci, Kamil</creatorcontrib><creatorcontrib>Telci, Lütfi</creatorcontrib><creatorcontrib>Akpir, Kutay</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiothoracic and vascular anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tuğrul, Mehmet</au><au>Çamci, Emre</au><au>Pembeci, Kamil</au><au>Telci, Lütfi</au><au>Akpir, Kutay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ketamine infusion versus isoflurane for the maintenance of anesthesia in the prebypass period in children with tetralogy of fallot</atitle><jtitle>Journal of cardiothoracic and vascular anesthesia</jtitle><addtitle>J Cardiothorac Vasc Anesth</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>14</volume><issue>5</issue><spage>557</spage><epage>561</epage><pages>557-561</pages><issn>1053-0770</issn><eissn>1532-8422</eissn><abstract><![CDATA[Objective: To evaluate the use of ketamine in comparison with isoflurane in the maintenance of anesthesia in children with tetralogy of Fallot. Design: Prospective, randomized study. Setting: University hospital. Participants: Fifty children scheduled for correction of tetralogy of Fallot. Interventions: After intubation, patients were assigned randomly to receive 2 different anesthesia maintenance regimens: group I, isoflurane, 0 to 1% plus fentanyl, 0.1 μg/kg/min; group II, ketamine, 0 to 5 mg/kg/h, plus fentanyl, 0.1 μg/kg/min. Isoflurane concentration and ketamine infusion rate were adjusted to maintain arterial pressure within 25% of baseline. Hemodynamic and respiratory parameters were recorded at the end of 4 intervals: T0, before induction of anesthesia; T1, induction to 10 minutes postintubation; T2, 10 minutes postintubation to poststernotomy; and T3, poststernotomy to completion of catheterizations. Measurements and Main Results: In comparing group I with group II, significant differences were observed in mean arterial pressure (p < 0.0001), heart rate (p < 0.01), arterial oxygen saturation (p < 0.0001), arterial oxygen tension (p < 0.001), arterial carbon dioxide tension (p < 0.001), arterial pH (p < 0.0001), base excess (p < 0.05), and arterial to end-tidal carbon dioxide tension difference (p < 0.01) at T3. Conclusion: The use of ketamine anesthesia is recommended as an alternative maintenance regimen in children undergoing definitive correction of tetralogy of Fallot. Copyright © 2000 by W.B. Saunders Company]]></abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>11052438</pmid><doi>10.1053/jcan.2000.9448</doi><tpages>5</tpages></addata></record> |
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| subjects | Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy arterial Biological and medical sciences Carbon Dioxide - blood cardiac surgery Child Child, Preschool Dopamine - pharmacology Epinephrine - pharmacology Hemodynamics - drug effects Hemoglobins - analysis Humans Infant intravenous anesthetics isoflurane Isoflurane - pharmacology ketamine Ketamine - pharmacology Medical sciences Oxygen - blood oxygenation Prospective Studies tetralogy of Fallot Tetralogy of Fallot - surgery Thoracic and cardiovascular surgery. Cardiopulmonary bypass volatile anesthetics |
| title | Ketamine infusion versus isoflurane for the maintenance of anesthesia in the prebypass period in children with tetralogy of fallot |
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