Dual effects of intravenous anesthetics on the function of Norepinephrine transporters

Norepinephrine transporters (NETs) terminate the neuronal transmission of norepinephrine, which is released from noradrenergic neurons. To investigate the interaction with NET, the authors examined the effects of short- and long-term treatment with anesthetics on the activity and mRNA level of NET....

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2000-11, Vol.93 (5), p.1329-1335
Hauptverfasser:	HARA, Koji, YANAGIHARA, Nobuyuki, MINAMI, Kouichiro, HIRANO, Hideyasu, SATA, Takeyoshi, SHIGEMATSU, Akio, IZUMI, Futoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Medulla - drug effects Adrenal Medulla - metabolism Adrenergic Uptake Inhibitors - pharmacology Anesthetics, Dissociative - pharmacology Anesthetics, Intravenous - pharmacology Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Carrier Proteins - antagonists & inhibitors Carrier Proteins - drug effects Carrier Proteins - physiology Cattle Cell Membrane - drug effects Cell Membrane - metabolism Cells, Cultured Desipramine - metabolism Diazepam - pharmacology Drug Administration Schedule Ketamine - pharmacology Kinetics Medical sciences Neuropharmacology Norepinephrine - metabolism Norepinephrine - pharmacokinetics Norepinephrine Plasma Membrane Transport Proteins Pharmacology. Drug treatments Propofol - pharmacology RNA, Messenger - metabolism Symporters Thiamylal - pharmacology Tritium
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