Effect of a selective 5-hydroxytryptamine reuptake inhibitor on brain extracellular noradrenaline: microdialysis studies using paroxetine

The clinical efficacy of selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors (SSRIs) is normally attributed to their ability to increase brain 5-HT function although recent preclinical findings indicate that their selectivity for 5-HT over noradrenaline may be less evident in vivo. T...

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Veröffentlicht in:	European journal of pharmacology 2000-10, Vol.407 (1), p.101-107
Hauptverfasser:	Hajós-Korcsok, Éva, McTavish, Sarah F.B, Sharp, Trevor
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT Adrenergic Uptake Inhibitors - pharmacology Animals Biological and medical sciences Desipramine Desipramine - pharmacology Hippocampus - drug effects Hippocampus - metabolism Male Medical sciences Microdialysis Neuropharmacology Noradrenaline Norepinephrine - metabolism Paroxetine Paroxetine - blood Paroxetine - pharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Serotonin - metabolism Serotonin Uptake Inhibitors - blood Serotonin Uptake Inhibitors - pharmacology
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