Non‐specific influx of T‐cell receptor alpha/beta and gamma/delta lymphocytes in mucosal biopsies from a patient with orofacial granulomatosis
: Orofacial granulomatosis (OFG) represents an inflammatory disorder of the facial and oral mucosa, histologically characterized by non‐caseating epithelioid cell granulomas. Since other granulomatous diseases have been shown to be characterized by a limited heterogeneity of alpha/beta and gamma/del...
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| Veröffentlicht in: | Journal of oral pathology & medicine 2000-11, Vol.29 (10), p.519-522 |
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| creator | Facchetti, F. Signorini, S. Majorana, A. Manganoni, M. A. Sapelli, P. Imberti, L. |
| description | : Orofacial granulomatosis (OFG) represents an inflammatory disorder of the facial and oral mucosa, histologically characterized by non‐caseating epithelioid cell granulomas. Since other granulomatous diseases have been shown to be characterized by a limited heterogeneity of alpha/beta and gamma/delta T cells, we investigated the T‐cell diversity of both types of lymphocytes obtained from the same OFG patient. When we compared the T‐cell receptor diversity of the lymphocytes accumulating at the site of the lesions with that of the peripheral blood counterpart, we did not find significant differences. Furthermore, no exclusive expansions of different T‐cell clones were seen in the patient. From these data we conclude that, in this OFG patient, the majority of T cells have no specificity for a single or for a few antigens and that tissue accumulation of T lymphocytes is the result of a random influx of cells at the site of inflammation. |
| doi_str_mv | 10.1034/j.1600-0714.2000.291007.x |
| format | Article |
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A. ; Sapelli, P. ; Imberti, L.</creator><creatorcontrib>Facchetti, F. ; Signorini, S. ; Majorana, A. ; Manganoni, M. A. ; Sapelli, P. ; Imberti, L.</creatorcontrib><description>: Orofacial granulomatosis (OFG) represents an inflammatory disorder of the facial and oral mucosa, histologically characterized by non‐caseating epithelioid cell granulomas. Since other granulomatous diseases have been shown to be characterized by a limited heterogeneity of alpha/beta and gamma/delta T cells, we investigated the T‐cell diversity of both types of lymphocytes obtained from the same OFG patient. When we compared the T‐cell receptor diversity of the lymphocytes accumulating at the site of the lesions with that of the peripheral blood counterpart, we did not find significant differences. Furthermore, no exclusive expansions of different T‐cell clones were seen in the patient. From these data we conclude that, in this OFG patient, the majority of T cells have no specificity for a single or for a few antigens and that tissue accumulation of T lymphocytes is the result of a random influx of cells at the site of inflammation.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1034/j.1600-0714.2000.291007.x</identifier><identifier>PMID: 11048969</identifier><language>eng</language><publisher>Copenhagen: Munksgaard International Publishers</publisher><subject>Adult ; Biological and medical sciences ; Dentistry ; Ent. Stomatology ; Female ; Gene Expression ; Genes, T-Cell Receptor ; Heteroduplex Analysis ; Humans ; immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Melkersson-Rosenthal Syndrome - genetics ; Melkersson-Rosenthal Syndrome - immunology ; Mouth Mucosa - immunology ; Mouth Mucosa - pathology ; Non tumoral diseases ; orofacial granulomatosis ; Otorhinolaryngology. Stomatology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Receptors, Antigen, T-Cell, alpha-beta - analysis ; Receptors, Antigen, T-Cell, alpha-beta - genetics ; Receptors, Antigen, T-Cell, gamma-delta - analysis ; Receptors, Antigen, T-Cell, gamma-delta - genetics ; T-Lymphocyte Subsets - immunology ; T‐cell receptor repertoire ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Journal of oral pathology & medicine, 2000-11, Vol.29 (10), p.519-522</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3997-23aa1fefd8a704a05f1ee413d93349f19e6f70fc0d1ee170733752ab641265fd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1600-0714.2000.291007.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1600-0714.2000.291007.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1492692$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11048969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Facchetti, F.</creatorcontrib><creatorcontrib>Signorini, S.</creatorcontrib><creatorcontrib>Majorana, A.</creatorcontrib><creatorcontrib>Manganoni, M. A.</creatorcontrib><creatorcontrib>Sapelli, P.</creatorcontrib><creatorcontrib>Imberti, L.</creatorcontrib><title>Non‐specific influx of T‐cell receptor alpha/beta and gamma/delta lymphocytes in mucosal biopsies from a patient with orofacial granulomatosis</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>: Orofacial granulomatosis (OFG) represents an inflammatory disorder of the facial and oral mucosa, histologically characterized by non‐caseating epithelioid cell granulomas. Since other granulomatous diseases have been shown to be characterized by a limited heterogeneity of alpha/beta and gamma/delta T cells, we investigated the T‐cell diversity of both types of lymphocytes obtained from the same OFG patient. When we compared the T‐cell receptor diversity of the lymphocytes accumulating at the site of the lesions with that of the peripheral blood counterpart, we did not find significant differences. Furthermore, no exclusive expansions of different T‐cell clones were seen in the patient. From these data we conclude that, in this OFG patient, the majority of T cells have no specificity for a single or for a few antigens and that tissue accumulation of T lymphocytes is the result of a random influx of cells at the site of inflammation.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Dentistry</subject><subject>Ent. Stomatology</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Genes, T-Cell Receptor</subject><subject>Heteroduplex Analysis</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Melkersson-Rosenthal Syndrome - genetics</subject><subject>Melkersson-Rosenthal Syndrome - immunology</subject><subject>Mouth Mucosa - immunology</subject><subject>Mouth Mucosa - pathology</subject><subject>Non tumoral diseases</subject><subject>orofacial granulomatosis</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - analysis</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - genetics</subject><subject>Receptors, Antigen, T-Cell, gamma-delta - analysis</subject><subject>Receptors, Antigen, T-Cell, gamma-delta - genetics</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T‐cell receptor repertoire</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2O0zAUhS0EYkrhFZCRELuk1z9NxjvQiF-NGBbD2rp17KkrJw5xoml3PALiEXkSHKVitqxsH3_3XPseQl4xKBkIuTmUrAIooGay5ABQcsUA6vL4iKz-3TwmK1AgC75l_II8S-kAwGoh2VNywRjIS1WpFfn9NXZ_fv5KvTXeeUN958J0pNHR2ywbGwIdrLH9GAeKod_jZmdHpNg19A7bFjeNDfkcTm2_j-Y02pQtaDuZmDDQnY998llzQ2wp0h5Hb7uR3vtxT-MQHRqfsbsBuynEFseYfHpOnjgMyb44r2vy_cP726tPxfXNx89X764LI5SqCy4QmbOuucQaJMLWMWslE40SQirHlK1cDc5Ak3VWQy1EveW4qyTj1dY1Yk3eLL79EH9MNo269Wn-MXY2TknXXGyVyG5rohbQDDGlwTrdD77F4aQZ6DkQfdDz2PU8dj0HopdA9DHXvjw3mXatbR4qzwlk4PUZwGQwuDwK49MDJxWvFM_Y2wW798Ge_v8B-svNt2Uv_gJtiqum</recordid><startdate>200011</startdate><enddate>200011</enddate><creator>Facchetti, F.</creator><creator>Signorini, S.</creator><creator>Majorana, A.</creator><creator>Manganoni, M. A.</creator><creator>Sapelli, P.</creator><creator>Imberti, L.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200011</creationdate><title>Non‐specific influx of T‐cell receptor alpha/beta and gamma/delta lymphocytes in mucosal biopsies from a patient with orofacial granulomatosis</title><author>Facchetti, F. ; Signorini, S. ; Majorana, A. ; Manganoni, M. A. ; Sapelli, P. ; Imberti, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3997-23aa1fefd8a704a05f1ee413d93349f19e6f70fc0d1ee170733752ab641265fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Dentistry</topic><topic>Ent. Stomatology</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Genes, T-Cell Receptor</topic><topic>Heteroduplex Analysis</topic><topic>Humans</topic><topic>immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Melkersson-Rosenthal Syndrome - genetics</topic><topic>Melkersson-Rosenthal Syndrome - immunology</topic><topic>Mouth Mucosa - immunology</topic><topic>Mouth Mucosa - pathology</topic><topic>Non tumoral diseases</topic><topic>orofacial granulomatosis</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - analysis</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - genetics</topic><topic>Receptors, Antigen, T-Cell, gamma-delta - analysis</topic><topic>Receptors, Antigen, T-Cell, gamma-delta - genetics</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T‐cell receptor repertoire</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Facchetti, F.</creatorcontrib><creatorcontrib>Signorini, S.</creatorcontrib><creatorcontrib>Majorana, A.</creatorcontrib><creatorcontrib>Manganoni, M. A.</creatorcontrib><creatorcontrib>Sapelli, P.</creatorcontrib><creatorcontrib>Imberti, L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Facchetti, F.</au><au>Signorini, S.</au><au>Majorana, A.</au><au>Manganoni, M. A.</au><au>Sapelli, P.</au><au>Imberti, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non‐specific influx of T‐cell receptor alpha/beta and gamma/delta lymphocytes in mucosal biopsies from a patient with orofacial granulomatosis</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2000-11</date><risdate>2000</risdate><volume>29</volume><issue>10</issue><spage>519</spage><epage>522</epage><pages>519-522</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>: Orofacial granulomatosis (OFG) represents an inflammatory disorder of the facial and oral mucosa, histologically characterized by non‐caseating epithelioid cell granulomas. Since other granulomatous diseases have been shown to be characterized by a limited heterogeneity of alpha/beta and gamma/delta T cells, we investigated the T‐cell diversity of both types of lymphocytes obtained from the same OFG patient. When we compared the T‐cell receptor diversity of the lymphocytes accumulating at the site of the lesions with that of the peripheral blood counterpart, we did not find significant differences. Furthermore, no exclusive expansions of different T‐cell clones were seen in the patient. From these data we conclude that, in this OFG patient, the majority of T cells have no specificity for a single or for a few antigens and that tissue accumulation of T lymphocytes is the result of a random influx of cells at the site of inflammation.</abstract><cop>Copenhagen</cop><pub>Munksgaard International Publishers</pub><pmid>11048969</pmid><doi>10.1034/j.1600-0714.2000.291007.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Dentistry Ent. Stomatology Female Gene Expression Genes, T-Cell Receptor Heteroduplex Analysis Humans immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Medical sciences Melkersson-Rosenthal Syndrome - genetics Melkersson-Rosenthal Syndrome - immunology Mouth Mucosa - immunology Mouth Mucosa - pathology Non tumoral diseases orofacial granulomatosis Otorhinolaryngology. Stomatology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptors, Antigen, T-Cell, alpha-beta - analysis Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, gamma-delta - analysis Receptors, Antigen, T-Cell, gamma-delta - genetics T-Lymphocyte Subsets - immunology T‐cell receptor repertoire Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Non‐specific influx of T‐cell receptor alpha/beta and gamma/delta lymphocytes in mucosal biopsies from a patient with orofacial granulomatosis |
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