The Effects of Intense Physical Exercise on Secondary Antibody Response in Young and Old Mice
Based largely on data from young subjects, intense physical exercise is believed to suppress immune function. In addition, immune function, including secondary antibody response, declines with advancing age. Therefore, intense exercise in old subjects may further suppress the secondary antibody resp...
Gespeichert in:
| Veröffentlicht in: | Physical therapy 2000-11, Vol.80 (11), p.1076-1086 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1086 |
|---|---|
| container_issue | 11 |
| container_start_page | 1076 |
| container_title | Physical therapy |
| container_volume | 80 |
| creator | Kapasi, Z F Catlin, P A Joyner, D R Lewis, M L Schwartz, A L Townsend, E L |
| description | Based largely on data from young subjects, intense physical exercise is believed to suppress immune function. In addition, immune function, including secondary antibody response, declines with advancing age. Therefore, intense exercise in old subjects may further suppress the secondary antibody response. The purpose of this in vivo study was to investigate the effects of intense physical exercise on secondary antibody response in young (6-8 weeks) and old (22-24 months) C57BL/6 mice.
Data were obtained from 22 young and 18 old C57BL/6 mice that were immunized to human serum albumin (HSA) and randomly divided into 3 groups. Two groups were exposed to a single bout of intense exercise to exhaustion and immediately boosted with an injection of HSA. The first group did not exercise further, but the second group continued with daily bouts of intense exercise to exhaustion for 9 days. The third group (control group) did not undergo intense exercise, but received the booster injection of HSA at the same time as the other groups. Ten days after the HSA booster injection, when high level of antibodies are produced in secondary antibody response, serum anti-HSA antibodies were measured by enzyme-linked immunosorbent assay.
Young mice did not show suppression of secondary antibody response following intense exercise. However, old mice, exposed to a single bout of intense exercise, had an enhanced response similar to the response seen in young control mice.
The widely accepted hypothesis of immunosuppression resulting from intense exercise may not be true for old mice. |
| doi_str_mv | 10.1093/ptj/80.11.1076 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_72358615</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A67406749</galeid><sourcerecordid>A67406749</sourcerecordid><originalsourceid>FETCH-LOGICAL-c574t-9f52349ea3a5561f7813fdb6ef9a57313de57db7dca268c6f0b8bb61948fb4413</originalsourceid><addsrcrecordid>eNptks-L1DAUx4Mo7jh69SjBgye7mzRt0x6HYdSFlRFdDx4kpOlLJ0OazCYt7vz3pszAurKEkJfH5315vxB6S8klJQ27Ooz7qzrZNH159QwtaMnqrOJ58RwtCGE0a0jOLtCrGPeEEMqL5iW6oJQUFW3KBfp9uwO80RrUGLHX-NqN4CLgb7tjNEpavLmHoEzyeId_gPKuk-GIV240re-O-DvEg58DjMO__OR6LF2Ht7bDX42C1-iFljbCm_O7RD8_bW7XX7Kb7efr9eomUyUvxqzRZc6KBiSTZVlRzWvKdNdWoBtZckZZByXvWt4pmVe1qjRp67ZNBRS1bouCsiX6cNI9BH83QRzFYKICa6UDP0XBc1bWVWrNEr3_D9z7KbiUm8hzRilvqhn6eIJ6aUEYp_0YpOrBQZDWO9AmuVcVL0i6TcKzJ_B0OhiMeop_LJ-QEe5H5a2FHkRqzHr7CL884Sr4GANocQhmSEMQlIh5B0TaAVEnm4p5B1LAu3ONUztA94Cfh_6Q8M70uz8mgIiDtDbh-ax1asg_gn8BOO-6Yw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223117965</pqid></control><display><type>article</type><title>The Effects of Intense Physical Exercise on Secondary Antibody Response in Young and Old Mice</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Kapasi, Z F ; Catlin, P A ; Joyner, D R ; Lewis, M L ; Schwartz, A L ; Townsend, E L</creator><creatorcontrib>Kapasi, Z F ; Catlin, P A ; Joyner, D R ; Lewis, M L ; Schwartz, A L ; Townsend, E L</creatorcontrib><description>Based largely on data from young subjects, intense physical exercise is believed to suppress immune function. In addition, immune function, including secondary antibody response, declines with advancing age. Therefore, intense exercise in old subjects may further suppress the secondary antibody response. The purpose of this in vivo study was to investigate the effects of intense physical exercise on secondary antibody response in young (6-8 weeks) and old (22-24 months) C57BL/6 mice.
Data were obtained from 22 young and 18 old C57BL/6 mice that were immunized to human serum albumin (HSA) and randomly divided into 3 groups. Two groups were exposed to a single bout of intense exercise to exhaustion and immediately boosted with an injection of HSA. The first group did not exercise further, but the second group continued with daily bouts of intense exercise to exhaustion for 9 days. The third group (control group) did not undergo intense exercise, but received the booster injection of HSA at the same time as the other groups. Ten days after the HSA booster injection, when high level of antibodies are produced in secondary antibody response, serum anti-HSA antibodies were measured by enzyme-linked immunosorbent assay.
Young mice did not show suppression of secondary antibody response following intense exercise. However, old mice, exposed to a single bout of intense exercise, had an enhanced response similar to the response seen in young control mice.
The widely accepted hypothesis of immunosuppression resulting from intense exercise may not be true for old mice.</description><identifier>ISSN: 0031-9023</identifier><identifier>EISSN: 1538-6724</identifier><identifier>DOI: 10.1093/ptj/80.11.1076</identifier><identifier>PMID: 11046195</identifier><language>eng</language><publisher>United States: American Physical Therapy Association</publisher><subject>Aging - physiology ; Analysis of Variance ; Animals ; Antibody Formation - physiology ; Exercise ; Exercise therapy ; Female ; Health aspects ; Immune system ; Methods ; Mice ; Mice, Inbred C57BL ; Physical Conditioning, Animal - physiology ; Physical therapy ; Random Allocation ; Rodents ; Therapeutics, Physiological</subject><ispartof>Physical therapy, 2000-11, Vol.80 (11), p.1076-1086</ispartof><rights>COPYRIGHT 2000 Oxford University Press</rights><rights>COPYRIGHT 2000 Oxford University Press</rights><rights>Copyright American Physical Therapy Association Nov 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c574t-9f52349ea3a5561f7813fdb6ef9a57313de57db7dca268c6f0b8bb61948fb4413</citedby><cites>FETCH-LOGICAL-c574t-9f52349ea3a5561f7813fdb6ef9a57313de57db7dca268c6f0b8bb61948fb4413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11046195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kapasi, Z F</creatorcontrib><creatorcontrib>Catlin, P A</creatorcontrib><creatorcontrib>Joyner, D R</creatorcontrib><creatorcontrib>Lewis, M L</creatorcontrib><creatorcontrib>Schwartz, A L</creatorcontrib><creatorcontrib>Townsend, E L</creatorcontrib><title>The Effects of Intense Physical Exercise on Secondary Antibody Response in Young and Old Mice</title><title>Physical therapy</title><addtitle>Phys Ther</addtitle><description>Based largely on data from young subjects, intense physical exercise is believed to suppress immune function. In addition, immune function, including secondary antibody response, declines with advancing age. Therefore, intense exercise in old subjects may further suppress the secondary antibody response. The purpose of this in vivo study was to investigate the effects of intense physical exercise on secondary antibody response in young (6-8 weeks) and old (22-24 months) C57BL/6 mice.
Data were obtained from 22 young and 18 old C57BL/6 mice that were immunized to human serum albumin (HSA) and randomly divided into 3 groups. Two groups were exposed to a single bout of intense exercise to exhaustion and immediately boosted with an injection of HSA. The first group did not exercise further, but the second group continued with daily bouts of intense exercise to exhaustion for 9 days. The third group (control group) did not undergo intense exercise, but received the booster injection of HSA at the same time as the other groups. Ten days after the HSA booster injection, when high level of antibodies are produced in secondary antibody response, serum anti-HSA antibodies were measured by enzyme-linked immunosorbent assay.
Young mice did not show suppression of secondary antibody response following intense exercise. However, old mice, exposed to a single bout of intense exercise, had an enhanced response similar to the response seen in young control mice.
The widely accepted hypothesis of immunosuppression resulting from intense exercise may not be true for old mice.</description><subject>Aging - physiology</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Antibody Formation - physiology</subject><subject>Exercise</subject><subject>Exercise therapy</subject><subject>Female</subject><subject>Health aspects</subject><subject>Immune system</subject><subject>Methods</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Physical therapy</subject><subject>Random Allocation</subject><subject>Rodents</subject><subject>Therapeutics, Physiological</subject><issn>0031-9023</issn><issn>1538-6724</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks-L1DAUx4Mo7jh69SjBgye7mzRt0x6HYdSFlRFdDx4kpOlLJ0OazCYt7vz3pszAurKEkJfH5315vxB6S8klJQ27Ooz7qzrZNH159QwtaMnqrOJ58RwtCGE0a0jOLtCrGPeEEMqL5iW6oJQUFW3KBfp9uwO80RrUGLHX-NqN4CLgb7tjNEpavLmHoEzyeId_gPKuk-GIV240re-O-DvEg58DjMO__OR6LF2Ht7bDX42C1-iFljbCm_O7RD8_bW7XX7Kb7efr9eomUyUvxqzRZc6KBiSTZVlRzWvKdNdWoBtZckZZByXvWt4pmVe1qjRp67ZNBRS1bouCsiX6cNI9BH83QRzFYKICa6UDP0XBc1bWVWrNEr3_D9z7KbiUm8hzRilvqhn6eIJ6aUEYp_0YpOrBQZDWO9AmuVcVL0i6TcKzJ_B0OhiMeop_LJ-QEe5H5a2FHkRqzHr7CL884Sr4GANocQhmSEMQlIh5B0TaAVEnm4p5B1LAu3ONUztA94Cfh_6Q8M70uz8mgIiDtDbh-ax1asg_gn8BOO-6Yw</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>Kapasi, Z F</creator><creator>Catlin, P A</creator><creator>Joyner, D R</creator><creator>Lewis, M L</creator><creator>Schwartz, A L</creator><creator>Townsend, E L</creator><general>American Physical Therapy Association</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20001101</creationdate><title>The Effects of Intense Physical Exercise on Secondary Antibody Response in Young and Old Mice</title><author>Kapasi, Z F ; Catlin, P A ; Joyner, D R ; Lewis, M L ; Schwartz, A L ; Townsend, E L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c574t-9f52349ea3a5561f7813fdb6ef9a57313de57db7dca268c6f0b8bb61948fb4413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aging - physiology</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Antibody Formation - physiology</topic><topic>Exercise</topic><topic>Exercise therapy</topic><topic>Female</topic><topic>Health aspects</topic><topic>Immune system</topic><topic>Methods</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Physical therapy</topic><topic>Random Allocation</topic><topic>Rodents</topic><topic>Therapeutics, Physiological</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kapasi, Z F</creatorcontrib><creatorcontrib>Catlin, P A</creatorcontrib><creatorcontrib>Joyner, D R</creatorcontrib><creatorcontrib>Lewis, M L</creatorcontrib><creatorcontrib>Schwartz, A L</creatorcontrib><creatorcontrib>Townsend, E L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Physical therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kapasi, Z F</au><au>Catlin, P A</au><au>Joyner, D R</au><au>Lewis, M L</au><au>Schwartz, A L</au><au>Townsend, E L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Intense Physical Exercise on Secondary Antibody Response in Young and Old Mice</atitle><jtitle>Physical therapy</jtitle><addtitle>Phys Ther</addtitle><date>2000-11-01</date><risdate>2000</risdate><volume>80</volume><issue>11</issue><spage>1076</spage><epage>1086</epage><pages>1076-1086</pages><issn>0031-9023</issn><eissn>1538-6724</eissn><abstract>Based largely on data from young subjects, intense physical exercise is believed to suppress immune function. In addition, immune function, including secondary antibody response, declines with advancing age. Therefore, intense exercise in old subjects may further suppress the secondary antibody response. The purpose of this in vivo study was to investigate the effects of intense physical exercise on secondary antibody response in young (6-8 weeks) and old (22-24 months) C57BL/6 mice.
Data were obtained from 22 young and 18 old C57BL/6 mice that were immunized to human serum albumin (HSA) and randomly divided into 3 groups. Two groups were exposed to a single bout of intense exercise to exhaustion and immediately boosted with an injection of HSA. The first group did not exercise further, but the second group continued with daily bouts of intense exercise to exhaustion for 9 days. The third group (control group) did not undergo intense exercise, but received the booster injection of HSA at the same time as the other groups. Ten days after the HSA booster injection, when high level of antibodies are produced in secondary antibody response, serum anti-HSA antibodies were measured by enzyme-linked immunosorbent assay.
Young mice did not show suppression of secondary antibody response following intense exercise. However, old mice, exposed to a single bout of intense exercise, had an enhanced response similar to the response seen in young control mice.
The widely accepted hypothesis of immunosuppression resulting from intense exercise may not be true for old mice.</abstract><cop>United States</cop><pub>American Physical Therapy Association</pub><pmid>11046195</pmid><doi>10.1093/ptj/80.11.1076</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-9023 |
| ispartof | Physical therapy, 2000-11, Vol.80 (11), p.1076-1086 |
| issn | 0031-9023 1538-6724 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72358615 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Aging - physiology Analysis of Variance Animals Antibody Formation - physiology Exercise Exercise therapy Female Health aspects Immune system Methods Mice Mice, Inbred C57BL Physical Conditioning, Animal - physiology Physical therapy Random Allocation Rodents Therapeutics, Physiological |
| title | The Effects of Intense Physical Exercise on Secondary Antibody Response in Young and Old Mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T12%3A51%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effects%20of%20Intense%20Physical%20Exercise%20on%20Secondary%20Antibody%20Response%20in%20Young%20and%20Old%20Mice&rft.jtitle=Physical%20therapy&rft.au=Kapasi,%20Z%20F&rft.date=2000-11-01&rft.volume=80&rft.issue=11&rft.spage=1076&rft.epage=1086&rft.pages=1076-1086&rft.issn=0031-9023&rft.eissn=1538-6724&rft_id=info:doi/10.1093/ptj/80.11.1076&rft_dat=%3Cgale_proqu%3EA67406749%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223117965&rft_id=info:pmid/11046195&rft_galeid=A67406749&rfr_iscdi=true |