Rational selection of antisense oligonucleotide sequences

The purpose of this review is to identify rational selection procedures for the identification of optimal antisense oligonucleotide sequences. The review is firstly focused on how to find optimal hybridization sites, and secondly on how to select sequences that bind to structured RNA. The methods re...

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Veröffentlicht in:	European Journal of Pharmaceutical Sciences 2000-09, Vol.11 (3), p.191-198
Hauptverfasser:	Smith, Lise, Andersen, Klaus Bahl, Hovgaard, Lars, Jaroszewski, Jerzy W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisense oligonucleotides Antisense selection Base Sequence Biological and medical sciences Biotechnology Drug Design Fundamental and applied biological sciences. Psychology General pharmacology Genetic engineering Genetic technics Medical sciences Methods. Procedures. Technologies Mfold Models, Molecular Molecular Sequence Data mRNA secondary structure mRNA targeting Nucleic Acid Conformation Oligodeoxyribonucleotides, Antisense - chemical synthesis Oligodeoxyribonucleotides, Antisense - chemistry Oligodeoxyribonucleotides, Antisense - pharmacology Oligonucleotides, Antisense - chemical synthesis Oligonucleotides, Antisense - chemistry Oligonucleotides, Antisense - pharmacology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Ribonuclease H - metabolism RNA, Messenger - chemistry RNA, Messenger - drug effects RNA, Messenger - genetics Structure-Activity Relationship Synthetic digonucleotides and genes. Sequencing
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