Studies on receptor binding and signal transduction pathways of unoprostone isopropyl

We examined the binding characteristics of unoprostone isopropyl and its metabolite, M1 (M1), in bovine corpus luteum membranes, mobilization of intracellular calcium in human ciliary muscle cells and cyclic AMP generation in rabbit iris-ciliary body. The ligand binding assay of 3H-unoprostone isopr...

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Veröffentlicht in:	Journal of ocular pharmacology and therapeutics 2001-10, Vol.17 (5), p.433-441
Hauptverfasser:	BHATTACHERJEE, Parimal, PATERSON, Christopher A, PERCICOT, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Animals Antihypertensive Agents - metabolism Binding, Competitive Biological and medical sciences Calcium - metabolism Cattle Ciliary Body - metabolism Corpus Luteum - metabolism Cyclic AMP - metabolism Dinoprost - analogs & derivatives Dinoprost - metabolism Eye Female Iris - metabolism Ligands Medical sciences Muscle, Smooth - metabolism Pharmacology. Drug treatments Rabbits Receptors, Prostaglandin - metabolism Signal Transduction
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