Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans
Recent cDNA cloning of the glycosyltransferases involved in the synthesis of the sulfated glycosaminoglycan sidechains of proteoglycans has provided important clues to answering long-standing questions concerning the mechanisms of both chain polymerization and the biosynthetic sorting of glucosamino...
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| Veröffentlicht in: | Current Opinion in Structural Biology 2000-10, Vol.10 (5), p.518-527 |
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| container_title | Current Opinion in Structural Biology |
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| creator | Sugahara, Kazuyuki Kitagawa, Hiroshi |
| description | Recent cDNA cloning of the glycosyltransferases involved in the synthesis of the sulfated glycosaminoglycan sidechains of proteoglycans has provided important clues to answering long-standing questions concerning the mechanisms of both chain polymerization and the biosynthetic sorting of glucosaminoglycans (heparin/heparan sulfate) and galactosaminoglycans (chondroitin/dermatan sulfate). These biosynthetic mechanisms are crucial to the expression and regulation of the biological functions of glycosaminoglycans in development and pathophysiology. |
| doi_str_mv | 10.1016/S0959-440X(00)00125-1 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0959-440X |
| ispartof | Current Opinion in Structural Biology, 2000-10, Vol.10 (5), p.518-527 |
| issn | 0959-440X 1879-033X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72355774 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Glycosaminoglycans - biosynthesis Glycosaminoglycans - chemistry Glycosaminoglycans - metabolism Proteins - metabolism Sulfates - metabolism |
| title | Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans |
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