Comparative microarray analysis of gene expression during apoptosis-induction by growth factor deprivation or protein kinase C inhibition

The transcriptional response of mouse pro-B cells to two different apoptotic stimuli was investigated. First, interleukin-3 (IL-3) deprivation was used to trigger programmed cell death in IL-3 dependent FL5.12 cells. Alternatively, cells were treated with the protein kinase C (PKC) inhibitor stauros...

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Veröffentlicht in:	Oncogene 2000-10, Vol.19 (44), p.5073-5082
Hauptverfasser:	BRACHAT, Arndt, PIERRAT, Benoit, BRÜNGGER, Adrian, HEIM, Jutta
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Animals Apoptosis Apoptosis - drug effects Apoptosis - genetics Apoptosis - physiology B-Lymphocytes - cytology B-Lymphocytes - physiology Biological and medical sciences Cell cycle Cell death Cell Division - genetics Cell Division - physiology Cell physiology Cellular stress response DNA microarrays DNA, Complementary - genetics Enzyme inhibitors Enzyme Inhibitors - pharmacology Expressed sequence tags Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Gene silencing Genetic aspects Growth factors Health aspects Interleukin 3 Interleukin-3 - deficiency Interleukin-3 - pharmacology Kinases Lymphocytes B Mice Molecular and cellular biology mRNA Multigene Family - physiology Physiological aspects Protein kinase C Protein Kinase C - antagonists & inhibitors Protein kinases RNA, Messenger - genetics RNA, Messenger - metabolism Staurosporine Staurosporine - pharmacology Transcription activation Transcription, Genetic - drug effects
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