The effects of transdermal estradiol on the response to mental stress in postmenopausal women: a randomized trial
PURPOSE: Estrogens inhibit adrenomedullary catecholamine release and catecholamine-mediated responses to stress. We examined whether estrogen supplementation reduces the sympathoadrenal response to mental stress in postmenopausal women. MATERIALS AND METHODS: We compared the effects of 3-week treatm...
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| Veröffentlicht in: | The American journal of medicine 2000-10, Vol.109 (6), p.463-468 |
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| creator | Ceresini, Graziano Freddi, Marilena Morganti, Simonetta Rebecchi, Isabella Modena, Alberto Bacchi Rinaldi, Maurizio Manca, Carlo Amaducci, Alberto Del Rio, Graziano Valenti, Giorgio |
| description | PURPOSE: Estrogens inhibit adrenomedullary catecholamine release and catecholamine-mediated responses to stress. We examined whether estrogen supplementation reduces the sympathoadrenal response to mental stress in postmenopausal women.
MATERIALS AND METHODS: We compared the effects of 3-week treatment with transdermal 17-beta-estradiol and placebo in 10 postmenopausal women using a randomized, blinded, crossover design. We measured plasma catecholamine levels and the cardiovascular and metabolic responses to a 15-minute stress with mental arithmetic. Treatments were compared using repeated measures analysis of variance.
RESULTS: During placebo treatment, mean (± SD) epinephrine levels reached a peak of 431 ± 135 pmol/liter after 15 minutes of stress; the epinephrine response was blunted during estradiol treatment, with a peak of 357 ± 77 pmol/liter (
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| doi_str_mv | 10.1016/S0002-9343(00)00523-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72354841</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002934300005234</els_id><sourcerecordid>64831412</sourcerecordid><originalsourceid>FETCH-LOGICAL-c464t-2ab1b9792602fdc9d905411f24deb54699a1aa168859b09d482e8b7852f789173</originalsourceid><addsrcrecordid>eNqFkV9rFTEQxYMo9lr9CEoQEfuwmmST3Y0vIsV_UPDB-hyymwmm7G62mV2L_fROey8W-uJTmMxvDjPnMPZcirdSyObdDyGEqmyt6zdCnAhhVF3pB2wnjTFVKxv1kO3-IUfsCeIFlcKa5jE7klJopWqzY5fnv4BDjDCsyHPka_EzBiiTHzkgVSHlkeeZr8QVwCXPCHzNfIJ5JYYQQORp5kvGlT7z4jekxlWm4j33nARDntI1BBJPfnzKHkU_Ijw7vMfs5-dP56dfq7PvX76dfjyrBt3otVK-l71trWqEimGwwQqjpYxKB-iNbqz10nvZdJ2xvbBBdwq6vu2Mim1nZVsfs9d73aXky41ucVPCAcbRz5A3dC3drzstCXx5D7zIW5lpN6dqRe7JxhJk9tBQMmKB6JaSJl_-OCncTSDuNhB347YTwt0G4jTNvTiIb_0E4W7qkAABrw6Ax8GPkewaEt5xRkm6ibAPewzIst8JisMhwTxASIWycyGn_2zyF6NXpuc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>232343169</pqid></control><display><type>article</type><title>The effects of transdermal estradiol on the response to mental stress in postmenopausal women: a randomized trial</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Ceresini, Graziano ; Freddi, Marilena ; Morganti, Simonetta ; Rebecchi, Isabella ; Modena, Alberto Bacchi ; Rinaldi, Maurizio ; Manca, Carlo ; Amaducci, Alberto ; Del Rio, Graziano ; Valenti, Giorgio</creator><creatorcontrib>Ceresini, Graziano ; Freddi, Marilena ; Morganti, Simonetta ; Rebecchi, Isabella ; Modena, Alberto Bacchi ; Rinaldi, Maurizio ; Manca, Carlo ; Amaducci, Alberto ; Del Rio, Graziano ; Valenti, Giorgio</creatorcontrib><description>PURPOSE: Estrogens inhibit adrenomedullary catecholamine release and catecholamine-mediated responses to stress. We examined whether estrogen supplementation reduces the sympathoadrenal response to mental stress in postmenopausal women.
MATERIALS AND METHODS: We compared the effects of 3-week treatment with transdermal 17-beta-estradiol and placebo in 10 postmenopausal women using a randomized, blinded, crossover design. We measured plasma catecholamine levels and the cardiovascular and metabolic responses to a 15-minute stress with mental arithmetic. Treatments were compared using repeated measures analysis of variance.
RESULTS: During placebo treatment, mean (± SD) epinephrine levels reached a peak of 431 ± 135 pmol/liter after 15 minutes of stress; the epinephrine response was blunted during estradiol treatment, with a peak of 357 ± 77 pmol/liter (
P <0.05). Estradiol also blunted the diastolic blood pressure response to stress (baseline levels of 78 ± 15 mm Hg vs peak of 90 ± 6 mm Hg during placebo; baseline of 80 ± 8 mm Hg vs peak of 84 ± 6 mm Hg during estradiol;
P <0.05). Estradiol treatment also blunted the decrease in the standard deviation of the mean of the electrocardiographic RR intervals and the increase in the ratio between the low-frequency and high-frequency bandwidths.
CONCLUSION: We observed a moderate, although significant, reduction in markers of the stress response to mental arithmetic in postmenopausal women treated with transdermal 17-beta-estradiol.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/S0002-9343(00)00523-4</identifier><identifier>PMID: 11042235</identifier><identifier>CODEN: AJMEAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Cutaneous ; Aged ; Analysis of Variance ; Biological and medical sciences ; Blood Pressure - drug effects ; Catecholamines - blood ; Clinical trials ; Cross-Over Studies ; Epinephrine - blood ; Estradiol - administration & dosage ; Estradiol - pharmacology ; Estrogens ; Female ; Genital system. Reproduction ; Heart Rate - drug effects ; Humans ; Mathematics ; Medical sciences ; Middle Aged ; Norepinephrine - blood ; Pharmacology. Drug treatments ; Postmenopause - blood ; Postmenopause - psychology ; Stress ; Stress, Psychological - prevention & control ; Transdermal medication ; Women</subject><ispartof>The American journal of medicine, 2000-10, Vol.109 (6), p.463-468</ispartof><rights>2000 Excerpta Medica Inc.</rights><rights>2000 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Oct 15, 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-2ab1b9792602fdc9d905411f24deb54699a1aa168859b09d482e8b7852f789173</citedby><cites>FETCH-LOGICAL-c464t-2ab1b9792602fdc9d905411f24deb54699a1aa168859b09d482e8b7852f789173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9343(00)00523-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1521852$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11042235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ceresini, Graziano</creatorcontrib><creatorcontrib>Freddi, Marilena</creatorcontrib><creatorcontrib>Morganti, Simonetta</creatorcontrib><creatorcontrib>Rebecchi, Isabella</creatorcontrib><creatorcontrib>Modena, Alberto Bacchi</creatorcontrib><creatorcontrib>Rinaldi, Maurizio</creatorcontrib><creatorcontrib>Manca, Carlo</creatorcontrib><creatorcontrib>Amaducci, Alberto</creatorcontrib><creatorcontrib>Del Rio, Graziano</creatorcontrib><creatorcontrib>Valenti, Giorgio</creatorcontrib><title>The effects of transdermal estradiol on the response to mental stress in postmenopausal women: a randomized trial</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>PURPOSE: Estrogens inhibit adrenomedullary catecholamine release and catecholamine-mediated responses to stress. We examined whether estrogen supplementation reduces the sympathoadrenal response to mental stress in postmenopausal women.
MATERIALS AND METHODS: We compared the effects of 3-week treatment with transdermal 17-beta-estradiol and placebo in 10 postmenopausal women using a randomized, blinded, crossover design. We measured plasma catecholamine levels and the cardiovascular and metabolic responses to a 15-minute stress with mental arithmetic. Treatments were compared using repeated measures analysis of variance.
RESULTS: During placebo treatment, mean (± SD) epinephrine levels reached a peak of 431 ± 135 pmol/liter after 15 minutes of stress; the epinephrine response was blunted during estradiol treatment, with a peak of 357 ± 77 pmol/liter (
P <0.05). Estradiol also blunted the diastolic blood pressure response to stress (baseline levels of 78 ± 15 mm Hg vs peak of 90 ± 6 mm Hg during placebo; baseline of 80 ± 8 mm Hg vs peak of 84 ± 6 mm Hg during estradiol;
P <0.05). Estradiol treatment also blunted the decrease in the standard deviation of the mean of the electrocardiographic RR intervals and the increase in the ratio between the low-frequency and high-frequency bandwidths.
CONCLUSION: We observed a moderate, although significant, reduction in markers of the stress response to mental arithmetic in postmenopausal women treated with transdermal 17-beta-estradiol.</description><subject>Administration, Cutaneous</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Catecholamines - blood</subject><subject>Clinical trials</subject><subject>Cross-Over Studies</subject><subject>Epinephrine - blood</subject><subject>Estradiol - administration & dosage</subject><subject>Estradiol - pharmacology</subject><subject>Estrogens</subject><subject>Female</subject><subject>Genital system. Reproduction</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Mathematics</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Norepinephrine - blood</subject><subject>Pharmacology. Drug treatments</subject><subject>Postmenopause - blood</subject><subject>Postmenopause - psychology</subject><subject>Stress</subject><subject>Stress, Psychological - prevention & control</subject><subject>Transdermal medication</subject><subject>Women</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFTEQxYMo9lr9CEoQEfuwmmST3Y0vIsV_UPDB-hyymwmm7G62mV2L_fROey8W-uJTmMxvDjPnMPZcirdSyObdDyGEqmyt6zdCnAhhVF3pB2wnjTFVKxv1kO3-IUfsCeIFlcKa5jE7klJopWqzY5fnv4BDjDCsyHPka_EzBiiTHzkgVSHlkeeZr8QVwCXPCHzNfIJ5JYYQQORp5kvGlT7z4jekxlWm4j33nARDntI1BBJPfnzKHkU_Ijw7vMfs5-dP56dfq7PvX76dfjyrBt3otVK-l71trWqEimGwwQqjpYxKB-iNbqz10nvZdJ2xvbBBdwq6vu2Mim1nZVsfs9d73aXky41ucVPCAcbRz5A3dC3drzstCXx5D7zIW5lpN6dqRe7JxhJk9tBQMmKB6JaSJl_-OCncTSDuNhB347YTwt0G4jTNvTiIb_0E4W7qkAABrw6Ax8GPkewaEt5xRkm6ibAPewzIst8JisMhwTxASIWycyGn_2zyF6NXpuc</recordid><startdate>20001015</startdate><enddate>20001015</enddate><creator>Ceresini, Graziano</creator><creator>Freddi, Marilena</creator><creator>Morganti, Simonetta</creator><creator>Rebecchi, Isabella</creator><creator>Modena, Alberto Bacchi</creator><creator>Rinaldi, Maurizio</creator><creator>Manca, Carlo</creator><creator>Amaducci, Alberto</creator><creator>Del Rio, Graziano</creator><creator>Valenti, Giorgio</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Sequoia S.A</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20001015</creationdate><title>The effects of transdermal estradiol on the response to mental stress in postmenopausal women: a randomized trial</title><author>Ceresini, Graziano ; Freddi, Marilena ; Morganti, Simonetta ; Rebecchi, Isabella ; Modena, Alberto Bacchi ; Rinaldi, Maurizio ; Manca, Carlo ; Amaducci, Alberto ; Del Rio, Graziano ; Valenti, Giorgio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-2ab1b9792602fdc9d905411f24deb54699a1aa168859b09d482e8b7852f789173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Administration, Cutaneous</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Catecholamines - blood</topic><topic>Clinical trials</topic><topic>Cross-Over Studies</topic><topic>Epinephrine - blood</topic><topic>Estradiol - administration & dosage</topic><topic>Estradiol - pharmacology</topic><topic>Estrogens</topic><topic>Female</topic><topic>Genital system. Reproduction</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Mathematics</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Norepinephrine - blood</topic><topic>Pharmacology. Drug treatments</topic><topic>Postmenopause - blood</topic><topic>Postmenopause - psychology</topic><topic>Stress</topic><topic>Stress, Psychological - prevention & control</topic><topic>Transdermal medication</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ceresini, Graziano</creatorcontrib><creatorcontrib>Freddi, Marilena</creatorcontrib><creatorcontrib>Morganti, Simonetta</creatorcontrib><creatorcontrib>Rebecchi, Isabella</creatorcontrib><creatorcontrib>Modena, Alberto Bacchi</creatorcontrib><creatorcontrib>Rinaldi, Maurizio</creatorcontrib><creatorcontrib>Manca, Carlo</creatorcontrib><creatorcontrib>Amaducci, Alberto</creatorcontrib><creatorcontrib>Del Rio, Graziano</creatorcontrib><creatorcontrib>Valenti, Giorgio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ceresini, Graziano</au><au>Freddi, Marilena</au><au>Morganti, Simonetta</au><au>Rebecchi, Isabella</au><au>Modena, Alberto Bacchi</au><au>Rinaldi, Maurizio</au><au>Manca, Carlo</au><au>Amaducci, Alberto</au><au>Del Rio, Graziano</au><au>Valenti, Giorgio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of transdermal estradiol on the response to mental stress in postmenopausal women: a randomized trial</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>2000-10-15</date><risdate>2000</risdate><volume>109</volume><issue>6</issue><spage>463</spage><epage>468</epage><pages>463-468</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><coden>AJMEAZ</coden><abstract>PURPOSE: Estrogens inhibit adrenomedullary catecholamine release and catecholamine-mediated responses to stress. We examined whether estrogen supplementation reduces the sympathoadrenal response to mental stress in postmenopausal women.
MATERIALS AND METHODS: We compared the effects of 3-week treatment with transdermal 17-beta-estradiol and placebo in 10 postmenopausal women using a randomized, blinded, crossover design. We measured plasma catecholamine levels and the cardiovascular and metabolic responses to a 15-minute stress with mental arithmetic. Treatments were compared using repeated measures analysis of variance.
RESULTS: During placebo treatment, mean (± SD) epinephrine levels reached a peak of 431 ± 135 pmol/liter after 15 minutes of stress; the epinephrine response was blunted during estradiol treatment, with a peak of 357 ± 77 pmol/liter (
P <0.05). Estradiol also blunted the diastolic blood pressure response to stress (baseline levels of 78 ± 15 mm Hg vs peak of 90 ± 6 mm Hg during placebo; baseline of 80 ± 8 mm Hg vs peak of 84 ± 6 mm Hg during estradiol;
P <0.05). Estradiol treatment also blunted the decrease in the standard deviation of the mean of the electrocardiographic RR intervals and the increase in the ratio between the low-frequency and high-frequency bandwidths.
CONCLUSION: We observed a moderate, although significant, reduction in markers of the stress response to mental arithmetic in postmenopausal women treated with transdermal 17-beta-estradiol.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11042235</pmid><doi>10.1016/S0002-9343(00)00523-4</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Cutaneous Aged Analysis of Variance Biological and medical sciences Blood Pressure - drug effects Catecholamines - blood Clinical trials Cross-Over Studies Epinephrine - blood Estradiol - administration & dosage Estradiol - pharmacology Estrogens Female Genital system. Reproduction Heart Rate - drug effects Humans Mathematics Medical sciences Middle Aged Norepinephrine - blood Pharmacology. Drug treatments Postmenopause - blood Postmenopause - psychology Stress Stress, Psychological - prevention & control Transdermal medication Women |
| title | The effects of transdermal estradiol on the response to mental stress in postmenopausal women: a randomized trial |
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