Expression of telomerase subunits in normal and neoplastic prostate epithelial cells isolated by laser capture microdissection

BACKGROUND Vertebrates have special structures at the ends of their chromosomes, known as telomeres, which may provide the chromosomes with stability and protect them from exonucleolytic degradation. The shortening of telomeric DNA with each cell division may lead to cell cycle arrest and/or apoptos...

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Veröffentlicht in:	Cancer 2001-10, Vol.92 (7), p.1943-1948
Hauptverfasser:	Liu, Brian C.‐S., LaRose, Ian, Weinstein, Lisa J., Ahn, Max, Weinstein, Michael H., Richie, Jerome P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Catalytic Domain DNA-Binding Proteins Epithelial Cells - enzymology hTERT Humans laser capture microdissection (LCM) Male Medical sciences Nephrology. Urinary tract diseases Prostate - enzymology Prostate - pathology prostate carcinoma Prostatic Neoplasms - enzymology Prostatic Neoplasms - pathology Reverse Transcriptase Polymerase Chain Reaction RNA - isolation & purification telomerase Telomerase - metabolism Tumors of the urinary system Urinary tract. Prostate gland
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