NO Modulates Monocyte Chemotactic Protein-1 Expression in Endothelial Cells Under Cyclic Strain

Endothelial cells (ECs) under hemodynamic forces increase intracellular reactive oxygen species (ROS) that modulate gene expression. We previously showed that NO attenuated the shear flow–induced gene level. The present study explored the role of endothelial NO in cyclic strain–treated ECs. Treatmen...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2001-12, Vol.21 (12), p.1941-1947
Hauptverfasser:	Wung, B S, Cheng, J J, Shyue, S -K, Wang, D L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood vessels and receptors Cattle Cells, Cultured Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Endothelium, Vascular - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Gene Transfer Techniques Hemodynamics - physiology Humans NADPH Oxidases - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase - genetics Oxidation-Reduction rac GTP-Binding Proteins - metabolism Reactive Oxygen Species - metabolism Stress, Mechanical Superoxides - metabolism Transcription, Genetic Umbilical Veins - cytology Vertebrates: cardiovascular system
Online-Zugang:	Volltext
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