Effect of aerobic training on diabetic nephropathy in a rat model of type 2 diabetes mellitus
The effect of aerobic exercise intervention on the renal functional and ultrastructural changes associated with diabetes mellitus were studied in the obese Zucker rat, a rat model of type 2 diabetes. The obese Zucker rats began training at 18 wk of age (n=8) and were compared to obese sedentary cont...
Gespeichert in:
| Veröffentlicht in: | Annals of clinical and laboratory science 2000-10, Vol.30 (4), p.346-353 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 353 |
|---|---|
| container_issue | 4 |
| container_start_page | 346 |
| container_title | Annals of clinical and laboratory science |
| container_volume | 30 |
| creator | CHIASERA, Janelle M WARD-COOK, Kory M MCCUNE, Sylvia A WARDLAW, Gordon M |
| description | The effect of aerobic exercise intervention on the renal functional and ultrastructural changes associated with diabetes mellitus were studied in the obese Zucker rat, a rat model of type 2 diabetes. The obese Zucker rats began training at 18 wk of age (n=8) and were compared to obese sedentary controls (n=12) and lean sedentary nondiseased littermates (n=10). Body weight, kidney weight, serum creatinine, urine creatinine, creatinine clearance, urine IgG, urine IgG/creatinine ratio, urine total protein, urine albumin, urine albumin/creatinine ratio, glycated hemoglobin, serum fructosamine, fasting serum glucose, serum insulin, serum total cholesterol, serum triglycerides, blood pressure, and morphometric analyses of cortical glomeruli by light microscopy and electron microscopy were performed to evaluate renal function, structure, and metabolic control. The exercise training consisted of treadmill running, 5 da/wk for 1 hr/da. Exercise intervention lowered the body weight (p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72352728</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72352728</sourcerecordid><originalsourceid>FETCH-LOGICAL-h265t-9483d3f3e5e8ed491d86c9e4b71eeed65aeeefee96957b76255068675827e9a53</originalsourceid><addsrcrecordid>eNo90E1LxDAQBuAgiruu_gUJCN4KaZrPoyyrKyx40aOUtJm6kTatSXrYf2_E6mlgeGaYd87QuuScFIooco7WhOiykJUkK3QV4ychVDNGLtGqLAnjkqs1et91HbQJjx02EMbGtTgF47zzH3j02DrTQMpND9MxjJNJxxN2HhscTMLDaKH_GU2nCTBdNEQ8QN-7NMdrdNGZPsLNUjfo7XH3ut0Xh5en5-3DoThSwVOhmaps1VXAQYFlurRKtBpYI0sAsIKbXDoALTSXjRQ0ZxRK5ABUgja82qD7371TGL9miKkeXGzzEcbDOMda0opTSVWGtwucmwFsPQU3mHCq_x6Swd0CTGxN3wXjWxf_ndQlZaL6BrkDafI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72352728</pqid></control><display><type>article</type><title>Effect of aerobic training on diabetic nephropathy in a rat model of type 2 diabetes mellitus</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>CHIASERA, Janelle M ; WARD-COOK, Kory M ; MCCUNE, Sylvia A ; WARDLAW, Gordon M</creator><creatorcontrib>CHIASERA, Janelle M ; WARD-COOK, Kory M ; MCCUNE, Sylvia A ; WARDLAW, Gordon M</creatorcontrib><description>The effect of aerobic exercise intervention on the renal functional and ultrastructural changes associated with diabetes mellitus were studied in the obese Zucker rat, a rat model of type 2 diabetes. The obese Zucker rats began training at 18 wk of age (n=8) and were compared to obese sedentary controls (n=12) and lean sedentary nondiseased littermates (n=10). Body weight, kidney weight, serum creatinine, urine creatinine, creatinine clearance, urine IgG, urine IgG/creatinine ratio, urine total protein, urine albumin, urine albumin/creatinine ratio, glycated hemoglobin, serum fructosamine, fasting serum glucose, serum insulin, serum total cholesterol, serum triglycerides, blood pressure, and morphometric analyses of cortical glomeruli by light microscopy and electron microscopy were performed to evaluate renal function, structure, and metabolic control. The exercise training consisted of treadmill running, 5 da/wk for 1 hr/da. Exercise intervention lowered the body weight (p <0.05), reduced the percentage of glycated hemoglobin (p <0.05), and diminished the urine albumin concentration (p <0.05), compared to the obese sedentary controls. Exercise intervention did not significantly affect morphometric indices of renal ultrastructure. This study shows that aerobic exercise intervention significantly improved metabolic control and reduced albuminuria in a rat model of type 2 diabetes.</description><identifier>ISSN: 0091-7370</identifier><identifier>EISSN: 1550-8080</identifier><identifier>PMID: 11045758</identifier><identifier>CODEN: ACLSCP</identifier><language>eng</language><publisher>Philadelphia, PA: Institute for Clinical Science</publisher><subject>Albuminuria - metabolism ; Albuminuria - pathology ; Albuminuria - therapy ; Animals ; Biological and medical sciences ; Blood Glucose ; Blood Pressure ; Cholesterol - blood ; Creatinine - urine ; Diabetes Mellitus - metabolism ; Diabetes Mellitus - pathology ; Diabetes Mellitus - therapy ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - pathology ; Diabetes Mellitus, Type 2 - therapy ; Diabetes. Impaired glucose tolerance ; Diabetic Nephropathies - metabolism ; Diabetic Nephropathies - pathology ; Diabetic Nephropathies - therapy ; Disease Models, Animal ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Fructosamine - blood ; Glycated Hemoglobin A - analysis ; Insulin - blood ; Kidney - metabolism ; Kidney - ultrastructure ; Kidney Glomerulus - metabolism ; Kidney Glomerulus - pathology ; Male ; Management. Various non-drug treatments. Langerhans islet grafts ; Medical sciences ; Obesity ; Organ Size ; Physical Conditioning, Animal - physiology ; Rats ; Rats, Zucker ; Triglycerides - blood</subject><ispartof>Annals of clinical and laboratory science, 2000-10, Vol.30 (4), p.346-353</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=791246$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11045758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHIASERA, Janelle M</creatorcontrib><creatorcontrib>WARD-COOK, Kory M</creatorcontrib><creatorcontrib>MCCUNE, Sylvia A</creatorcontrib><creatorcontrib>WARDLAW, Gordon M</creatorcontrib><title>Effect of aerobic training on diabetic nephropathy in a rat model of type 2 diabetes mellitus</title><title>Annals of clinical and laboratory science</title><addtitle>Ann Clin Lab Sci</addtitle><description>The effect of aerobic exercise intervention on the renal functional and ultrastructural changes associated with diabetes mellitus were studied in the obese Zucker rat, a rat model of type 2 diabetes. The obese Zucker rats began training at 18 wk of age (n=8) and were compared to obese sedentary controls (n=12) and lean sedentary nondiseased littermates (n=10). Body weight, kidney weight, serum creatinine, urine creatinine, creatinine clearance, urine IgG, urine IgG/creatinine ratio, urine total protein, urine albumin, urine albumin/creatinine ratio, glycated hemoglobin, serum fructosamine, fasting serum glucose, serum insulin, serum total cholesterol, serum triglycerides, blood pressure, and morphometric analyses of cortical glomeruli by light microscopy and electron microscopy were performed to evaluate renal function, structure, and metabolic control. The exercise training consisted of treadmill running, 5 da/wk for 1 hr/da. Exercise intervention lowered the body weight (p <0.05), reduced the percentage of glycated hemoglobin (p <0.05), and diminished the urine albumin concentration (p <0.05), compared to the obese sedentary controls. Exercise intervention did not significantly affect morphometric indices of renal ultrastructure. This study shows that aerobic exercise intervention significantly improved metabolic control and reduced albuminuria in a rat model of type 2 diabetes.</description><subject>Albuminuria - metabolism</subject><subject>Albuminuria - pathology</subject><subject>Albuminuria - therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose</subject><subject>Blood Pressure</subject><subject>Cholesterol - blood</subject><subject>Creatinine - urine</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetes Mellitus - pathology</subject><subject>Diabetes Mellitus - therapy</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Diabetes Mellitus, Type 2 - therapy</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Nephropathies - metabolism</subject><subject>Diabetic Nephropathies - pathology</subject><subject>Diabetic Nephropathies - therapy</subject><subject>Disease Models, Animal</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Fructosamine - blood</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Insulin - blood</subject><subject>Kidney - metabolism</subject><subject>Kidney - ultrastructure</subject><subject>Kidney Glomerulus - metabolism</subject><subject>Kidney Glomerulus - pathology</subject><subject>Male</subject><subject>Management. Various non-drug treatments. Langerhans islet grafts</subject><subject>Medical sciences</subject><subject>Obesity</subject><subject>Organ Size</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Rats</subject><subject>Rats, Zucker</subject><subject>Triglycerides - blood</subject><issn>0091-7370</issn><issn>1550-8080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90E1LxDAQBuAgiruu_gUJCN4KaZrPoyyrKyx40aOUtJm6kTatSXrYf2_E6mlgeGaYd87QuuScFIooco7WhOiykJUkK3QV4ychVDNGLtGqLAnjkqs1et91HbQJjx02EMbGtTgF47zzH3j02DrTQMpND9MxjJNJxxN2HhscTMLDaKH_GU2nCTBdNEQ8QN-7NMdrdNGZPsLNUjfo7XH3ut0Xh5en5-3DoThSwVOhmaps1VXAQYFlurRKtBpYI0sAsIKbXDoALTSXjRQ0ZxRK5ABUgja82qD7371TGL9miKkeXGzzEcbDOMda0opTSVWGtwucmwFsPQU3mHCq_x6Swd0CTGxN3wXjWxf_ndQlZaL6BrkDafI</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>CHIASERA, Janelle M</creator><creator>WARD-COOK, Kory M</creator><creator>MCCUNE, Sylvia A</creator><creator>WARDLAW, Gordon M</creator><general>Institute for Clinical Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Effect of aerobic training on diabetic nephropathy in a rat model of type 2 diabetes mellitus</title><author>CHIASERA, Janelle M ; WARD-COOK, Kory M ; MCCUNE, Sylvia A ; WARDLAW, Gordon M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h265t-9483d3f3e5e8ed491d86c9e4b71eeed65aeeefee96957b76255068675827e9a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Albuminuria - metabolism</topic><topic>Albuminuria - pathology</topic><topic>Albuminuria - therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose</topic><topic>Blood Pressure</topic><topic>Cholesterol - blood</topic><topic>Creatinine - urine</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diabetes Mellitus - pathology</topic><topic>Diabetes Mellitus - therapy</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - pathology</topic><topic>Diabetes Mellitus, Type 2 - therapy</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Nephropathies - metabolism</topic><topic>Diabetic Nephropathies - pathology</topic><topic>Diabetic Nephropathies - therapy</topic><topic>Disease Models, Animal</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Fructosamine - blood</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Insulin - blood</topic><topic>Kidney - metabolism</topic><topic>Kidney - ultrastructure</topic><topic>Kidney Glomerulus - metabolism</topic><topic>Kidney Glomerulus - pathology</topic><topic>Male</topic><topic>Management. Various non-drug treatments. Langerhans islet grafts</topic><topic>Medical sciences</topic><topic>Obesity</topic><topic>Organ Size</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Rats</topic><topic>Rats, Zucker</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHIASERA, Janelle M</creatorcontrib><creatorcontrib>WARD-COOK, Kory M</creatorcontrib><creatorcontrib>MCCUNE, Sylvia A</creatorcontrib><creatorcontrib>WARDLAW, Gordon M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of clinical and laboratory science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHIASERA, Janelle M</au><au>WARD-COOK, Kory M</au><au>MCCUNE, Sylvia A</au><au>WARDLAW, Gordon M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of aerobic training on diabetic nephropathy in a rat model of type 2 diabetes mellitus</atitle><jtitle>Annals of clinical and laboratory science</jtitle><addtitle>Ann Clin Lab Sci</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>30</volume><issue>4</issue><spage>346</spage><epage>353</epage><pages>346-353</pages><issn>0091-7370</issn><eissn>1550-8080</eissn><coden>ACLSCP</coden><abstract>The effect of aerobic exercise intervention on the renal functional and ultrastructural changes associated with diabetes mellitus were studied in the obese Zucker rat, a rat model of type 2 diabetes. The obese Zucker rats began training at 18 wk of age (n=8) and were compared to obese sedentary controls (n=12) and lean sedentary nondiseased littermates (n=10). Body weight, kidney weight, serum creatinine, urine creatinine, creatinine clearance, urine IgG, urine IgG/creatinine ratio, urine total protein, urine albumin, urine albumin/creatinine ratio, glycated hemoglobin, serum fructosamine, fasting serum glucose, serum insulin, serum total cholesterol, serum triglycerides, blood pressure, and morphometric analyses of cortical glomeruli by light microscopy and electron microscopy were performed to evaluate renal function, structure, and metabolic control. The exercise training consisted of treadmill running, 5 da/wk for 1 hr/da. Exercise intervention lowered the body weight (p <0.05), reduced the percentage of glycated hemoglobin (p <0.05), and diminished the urine albumin concentration (p <0.05), compared to the obese sedentary controls. Exercise intervention did not significantly affect morphometric indices of renal ultrastructure. This study shows that aerobic exercise intervention significantly improved metabolic control and reduced albuminuria in a rat model of type 2 diabetes.</abstract><cop>Philadelphia, PA</cop><pub>Institute for Clinical Science</pub><pmid>11045758</pmid><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-7370 |
| ispartof | Annals of clinical and laboratory science, 2000-10, Vol.30 (4), p.346-353 |
| issn | 0091-7370 1550-8080 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72352728 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Albuminuria - metabolism Albuminuria - pathology Albuminuria - therapy Animals Biological and medical sciences Blood Glucose Blood Pressure Cholesterol - blood Creatinine - urine Diabetes Mellitus - metabolism Diabetes Mellitus - pathology Diabetes Mellitus - therapy Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - therapy Diabetes. Impaired glucose tolerance Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic Nephropathies - therapy Disease Models, Animal Endocrine pancreas. Apud cells (diseases) Endocrinopathies Fructosamine - blood Glycated Hemoglobin A - analysis Insulin - blood Kidney - metabolism Kidney - ultrastructure Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Male Management. Various non-drug treatments. Langerhans islet grafts Medical sciences Obesity Organ Size Physical Conditioning, Animal - physiology Rats Rats, Zucker Triglycerides - blood |
| title | Effect of aerobic training on diabetic nephropathy in a rat model of type 2 diabetes mellitus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T08%3A15%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20aerobic%20training%20on%20diabetic%20nephropathy%20in%20a%20rat%20model%20of%20type%202%20diabetes%20mellitus&rft.jtitle=Annals%20of%20clinical%20and%20laboratory%20science&rft.au=CHIASERA,%20Janelle%20M&rft.date=2000-10-01&rft.volume=30&rft.issue=4&rft.spage=346&rft.epage=353&rft.pages=346-353&rft.issn=0091-7370&rft.eissn=1550-8080&rft.coden=ACLSCP&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E72352728%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72352728&rft_id=info:pmid/11045758&rfr_iscdi=true |