Repeated stimulation of L-type calcium channels in the rat ventral tegmental area mimics the initiation of behavioral sensitization to cocaine
A substantial body of evidence indicates that ion flux through L-type calcium channels and N-methyl-D-aspartate (NMDA) receptors contributes to behavioral sensitization to cocaine. The following experiments were designed to evaluate the role of calcium influx through L-type calcium channels or NMDA...
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| Veröffentlicht in: | Psychopharmacologia 2000-09, Vol.152 (1), p.110-118 |
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| container_title | Psychopharmacologia |
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| creator | LICATA, S. C FREEMAN, A. Y PIERCE-BANCROFT, A. F PIERCE, R. C |
| description | A substantial body of evidence indicates that ion flux through L-type calcium channels and N-methyl-D-aspartate (NMDA) receptors contributes to behavioral sensitization to cocaine.
The following experiments were designed to evaluate the role of calcium influx through L-type calcium channels or NMDA receptors in the ventral tegmental area (VTA) in the initiation of behavioral sensitization to cocaine.
The L-type calcium channel agonist BayK 8644, the glutamate agonist NMDA, or vehicle was microinjected into the VTA on 3 consecutive days. Following a 2-week withdrawal period, all rats received a challenge injection of cocaine (15 mg/kg, i.p.) in order to assess potential cross-sensitization with the NMDA or BayK 8644 pretreatments.
Repeated intra-VTA microinjections of BayK 8644, but not NMDA, resulted in an augmentation of the behavioral response to cocaine.
These results indicate that calcium influx through L-type calcium channels produces neurophysiological adaptations that mimic those resulting from intermittent exposure to cocaine. |
| doi_str_mv | 10.1007/s002130000518 |
| format | Article |
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The following experiments were designed to evaluate the role of calcium influx through L-type calcium channels or NMDA receptors in the ventral tegmental area (VTA) in the initiation of behavioral sensitization to cocaine.
The L-type calcium channel agonist BayK 8644, the glutamate agonist NMDA, or vehicle was microinjected into the VTA on 3 consecutive days. Following a 2-week withdrawal period, all rats received a challenge injection of cocaine (15 mg/kg, i.p.) in order to assess potential cross-sensitization with the NMDA or BayK 8644 pretreatments.
Repeated intra-VTA microinjections of BayK 8644, but not NMDA, resulted in an augmentation of the behavioral response to cocaine.
These results indicate that calcium influx through L-type calcium channels produces neurophysiological adaptations that mimic those resulting from intermittent exposure to cocaine.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s002130000518</identifier><identifier>PMID: 11041323</identifier><identifier>CODEN: PSYPAG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology ; Agonists ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Calcium Channel Agonists - pharmacology ; Calcium channels ; Calcium channels (L-type) ; Calcium Channels, L-Type - drug effects ; Calcium influx ; Cocaine ; Cocaine - pharmacology ; Dopamine Uptake Inhibitors - pharmacology ; Drug addictions ; Glutamate receptors ; Glutamic acid receptors (ionotropic) ; Male ; Medical sciences ; Microinjections ; N-Methyl-D-aspartic acid receptors ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate - agonists ; Stereotyped Behavior - drug effects ; Toxicology ; ventral tegmental area ; Ventral Tegmental Area - physiology ; Ventral tegmentum</subject><ispartof>Psychopharmacologia, 2000-09, Vol.152 (1), p.110-118</ispartof><rights>2000 INIST-CNRS</rights><rights>Springer-Verlag 2000.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-6de9bae18bc6c7ad78fcd56fcb78d8a319e3f628981f56c61fbeaee37cec5afa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1496240$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11041323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LICATA, S. C</creatorcontrib><creatorcontrib>FREEMAN, A. Y</creatorcontrib><creatorcontrib>PIERCE-BANCROFT, A. F</creatorcontrib><creatorcontrib>PIERCE, R. C</creatorcontrib><title>Repeated stimulation of L-type calcium channels in the rat ventral tegmental area mimics the initiation of behavioral sensitization to cocaine</title><title>Psychopharmacologia</title><addtitle>Psychopharmacology (Berl)</addtitle><description>A substantial body of evidence indicates that ion flux through L-type calcium channels and N-methyl-D-aspartate (NMDA) receptors contributes to behavioral sensitization to cocaine.
The following experiments were designed to evaluate the role of calcium influx through L-type calcium channels or NMDA receptors in the ventral tegmental area (VTA) in the initiation of behavioral sensitization to cocaine.
The L-type calcium channel agonist BayK 8644, the glutamate agonist NMDA, or vehicle was microinjected into the VTA on 3 consecutive days. Following a 2-week withdrawal period, all rats received a challenge injection of cocaine (15 mg/kg, i.p.) in order to assess potential cross-sensitization with the NMDA or BayK 8644 pretreatments.
Repeated intra-VTA microinjections of BayK 8644, but not NMDA, resulted in an augmentation of the behavioral response to cocaine.
These results indicate that calcium influx through L-type calcium channels produces neurophysiological adaptations that mimic those resulting from intermittent exposure to cocaine.</description><subject>3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology</subject><subject>Agonists</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Calcium Channel Agonists - pharmacology</subject><subject>Calcium channels</subject><subject>Calcium channels (L-type)</subject><subject>Calcium Channels, L-Type - drug effects</subject><subject>Calcium influx</subject><subject>Cocaine</subject><subject>Cocaine - pharmacology</subject><subject>Dopamine Uptake Inhibitors - pharmacology</subject><subject>Drug addictions</subject><subject>Glutamate receptors</subject><subject>Glutamic acid receptors (ionotropic)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microinjections</subject><subject>N-Methyl-D-aspartic acid receptors</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, N-Methyl-D-Aspartate - agonists</subject><subject>Stereotyped Behavior - drug effects</subject><subject>Toxicology</subject><subject>ventral tegmental area</subject><subject>Ventral Tegmental Area - physiology</subject><subject>Ventral tegmentum</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0U2LFDEQBuAgijuuHr1KQPHWaz66k_RRFr9gYEH03FSnK06W7mRM0gvrj_A3b8YZXPSyuaSgnhRUXkJecnbBGdPvMmOCS1ZPx80jsuGtFI1gWjwmG8akbCTvzBl5lvP1AbWmfUrOOGctl0JuyO-vuEcoONFc_LLOUHwMNDq6bcrtHqmF2fp1oXYHIeCcqQ-07JAmKPQGQ0kw04I_llrWChICXfzibf6jfPDF_x054g5ufDw8yRhybf069kqkNlrwAZ-TJw7mjC9O9zn5_vHDt8vPzfbq05fL99vGtq0sjZqwHwG5Ga2yGiZtnJ065eyozWRA8h6lU8L0hrtOWcXdiIAotUXbgQN5Tt4e5-5T_LliLsPis8V5hoBxzYMWshOdEg9CrpWU9ScrfP0fvI5rCnWJQXKuDZNt31XVHJVNMeeEbtgnv0C6HTgbDnkO_-RZ_avT1HVccLrXpwAreHMCkGtWLkGwPt-7tleiZfIOPb6qcg</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>LICATA, S. 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C</au><au>FREEMAN, A. Y</au><au>PIERCE-BANCROFT, A. F</au><au>PIERCE, R. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Repeated stimulation of L-type calcium channels in the rat ventral tegmental area mimics the initiation of behavioral sensitization to cocaine</atitle><jtitle>Psychopharmacologia</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>152</volume><issue>1</issue><spage>110</spage><epage>118</epage><pages>110-118</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><coden>PSYPAG</coden><abstract>A substantial body of evidence indicates that ion flux through L-type calcium channels and N-methyl-D-aspartate (NMDA) receptors contributes to behavioral sensitization to cocaine.
The following experiments were designed to evaluate the role of calcium influx through L-type calcium channels or NMDA receptors in the ventral tegmental area (VTA) in the initiation of behavioral sensitization to cocaine.
The L-type calcium channel agonist BayK 8644, the glutamate agonist NMDA, or vehicle was microinjected into the VTA on 3 consecutive days. Following a 2-week withdrawal period, all rats received a challenge injection of cocaine (15 mg/kg, i.p.) in order to assess potential cross-sensitization with the NMDA or BayK 8644 pretreatments.
Repeated intra-VTA microinjections of BayK 8644, but not NMDA, resulted in an augmentation of the behavioral response to cocaine.
These results indicate that calcium influx through L-type calcium channels produces neurophysiological adaptations that mimic those resulting from intermittent exposure to cocaine.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>11041323</pmid><doi>10.1007/s002130000518</doi><tpages>9</tpages></addata></record> |
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| ispartof | Psychopharmacologia, 2000-09, Vol.152 (1), p.110-118 |
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| subjects | 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Agonists Animals Behavior, Animal - drug effects Biological and medical sciences Calcium Channel Agonists - pharmacology Calcium channels Calcium channels (L-type) Calcium Channels, L-Type - drug effects Calcium influx Cocaine Cocaine - pharmacology Dopamine Uptake Inhibitors - pharmacology Drug addictions Glutamate receptors Glutamic acid receptors (ionotropic) Male Medical sciences Microinjections N-Methyl-D-aspartic acid receptors Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - agonists Stereotyped Behavior - drug effects Toxicology ventral tegmental area Ventral Tegmental Area - physiology Ventral tegmentum |
| title | Repeated stimulation of L-type calcium channels in the rat ventral tegmental area mimics the initiation of behavioral sensitization to cocaine |
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