Interaction with CBP/p300 enables the bovine papillomavirus type 1 E6 oncoprotein to downregulate CBP/p300-mediated transactivation by p53
The E6 oncoprotein of bovine papillomavirus type 1 (BPV-1) can transform cells independently of p53 degradation. The precise mechanisms underlying this transformation are not yet completely understood. Here it is shown that BPV-1 E6 interacts with CBP/p300 in the same way as described for the E6 pro...
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| Veröffentlicht in: | Journal of general virology 2000-11, Vol.81 (11), p.2617-2623 |
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| container_title | Journal of general virology |
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| creator | Zimmermann, H Koh, C.H Degenkolbe, R O'Connor, M.J Muller, A Steger, G Chen, J.J Lui, Y Androphy, E Bernard, H.U |
| description | The E6 oncoprotein of bovine papillomavirus type 1 (BPV-1) can transform cells independently of p53 degradation. The precise mechanisms underlying this transformation are not yet completely understood. Here it is shown that BPV-1 E6 interacts with CBP/p300 in the same way as described for the E6 proteins of oncogenic human papillomaviruses. This interaction results in an inhibition of the transcriptional coactivator function of CBP/p300 required by p53 and probably by other transcription factors. The comparison of the CBP/p300-binding properties of BPV-1 E6 mutants previously characterized in transcription and transformation studies suggests (i) that the E6-CBP/p300 interaction may be necessary, but not sufficient, for cell transformation, and (ii) that the transcriptional activator function, inherent to the E6 protein, is not derived from forming a complex with CBP/p300. |
| doi_str_mv | 10.1099/0022-1317-81-11-2617 |
| format | Article |
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The precise mechanisms underlying this transformation are not yet completely understood. Here it is shown that BPV-1 E6 interacts with CBP/p300 in the same way as described for the E6 proteins of oncogenic human papillomaviruses. This interaction results in an inhibition of the transcriptional coactivator function of CBP/p300 required by p53 and probably by other transcription factors. The comparison of the CBP/p300-binding properties of BPV-1 E6 mutants previously characterized in transcription and transformation studies suggests (i) that the E6-CBP/p300 interaction may be necessary, but not sufficient, for cell transformation, and (ii) that the transcriptional activator function, inherent to the E6 protein, is not derived from forming a complex with CBP/p300.</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/0022-1317-81-11-2617</identifier><identifier>PMID: 11038372</identifier><language>eng</language><publisher>England: Soc General Microbiol</publisher><subject>Animals ; Bovine papillomavirus 1 ; Bovine papillomavirus 1 - genetics ; Cattle ; CBP protein ; Cell Line ; Cell Transformation, Viral ; Down-Regulation ; E6 protein ; Gene Expression Regulation, Viral ; Genes, p53 ; Humans ; mutants ; Nuclear Proteins - genetics ; oncogene proteins ; Oncogene Proteins, Viral - genetics ; p300 protein ; p53 protein ; Trans-Activators - genetics ; transactivators ; transcription (genetics) ; Transcriptional Activation</subject><ispartof>Journal of general virology, 2000-11, Vol.81 (11), p.2617-2623</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-c4f7a37ebf2a64afa80edc92fb3682e2f906fa9a2e14f310b7d8b3be31e17e843</citedby><cites>FETCH-LOGICAL-c438t-c4f7a37ebf2a64afa80edc92fb3682e2f906fa9a2e14f310b7d8b3be31e17e843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3747,3748,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11038372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zimmermann, H</creatorcontrib><creatorcontrib>Koh, C.H</creatorcontrib><creatorcontrib>Degenkolbe, R</creatorcontrib><creatorcontrib>O'Connor, M.J</creatorcontrib><creatorcontrib>Muller, A</creatorcontrib><creatorcontrib>Steger, G</creatorcontrib><creatorcontrib>Chen, J.J</creatorcontrib><creatorcontrib>Lui, Y</creatorcontrib><creatorcontrib>Androphy, E</creatorcontrib><creatorcontrib>Bernard, H.U</creatorcontrib><title>Interaction with CBP/p300 enables the bovine papillomavirus type 1 E6 oncoprotein to downregulate CBP/p300-mediated transactivation by p53</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>The E6 oncoprotein of bovine papillomavirus type 1 (BPV-1) can transform cells independently of p53 degradation. The precise mechanisms underlying this transformation are not yet completely understood. Here it is shown that BPV-1 E6 interacts with CBP/p300 in the same way as described for the E6 proteins of oncogenic human papillomaviruses. This interaction results in an inhibition of the transcriptional coactivator function of CBP/p300 required by p53 and probably by other transcription factors. The comparison of the CBP/p300-binding properties of BPV-1 E6 mutants previously characterized in transcription and transformation studies suggests (i) that the E6-CBP/p300 interaction may be necessary, but not sufficient, for cell transformation, and (ii) that the transcriptional activator function, inherent to the E6 protein, is not derived from forming a complex with CBP/p300.</description><subject>Animals</subject><subject>Bovine papillomavirus 1</subject><subject>Bovine papillomavirus 1 - genetics</subject><subject>Cattle</subject><subject>CBP protein</subject><subject>Cell Line</subject><subject>Cell Transformation, Viral</subject><subject>Down-Regulation</subject><subject>E6 protein</subject><subject>Gene Expression Regulation, Viral</subject><subject>Genes, p53</subject><subject>Humans</subject><subject>mutants</subject><subject>Nuclear Proteins - genetics</subject><subject>oncogene proteins</subject><subject>Oncogene Proteins, Viral - genetics</subject><subject>p300 protein</subject><subject>p53 protein</subject><subject>Trans-Activators - genetics</subject><subject>transactivators</subject><subject>transcription (genetics)</subject><subject>Transcriptional Activation</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdGO1CAUhhujcWdX38AoVyZ7UZcDTKGXOll1k0000b0m0J7OYNpSgc5kXsGnljqTNV55Awl85_8JX1G8AvoOaF3fUMpYCRxkqaAEKFkF8kmxAlGtS5aBp8XqEbkoLmP8QSkIsZbPiwsAyhWXbFX8uhsTBtMk50dycGlHNh--3kycUoKjsT1GknZIrN-7EclkJtf3fjB7F-Z8c5yQALmtiB8bPwWf0I0kedL6wxhwO_cm4WNgOWDr8kFLUjBjXDr35k-vPZJpzV8UzzrTR3x53q-Kh4-33zefy_svn-427-_LRnCV8tpJwyXajplKmM4oim1Ts87ySjFkXU2rztSGIYiOA7WyVZZb5IAgUQl-Vbw95eYH_5wxJj242GDfmxH9HLVkfA2K1_8FQVZcUqUyKE5gE3yMATs9BTeYcNRA9SJLLyb0YkIr0AB6kZXHXp_zZ5v_5u_Q2U4Grk_Azm13BxdQb3EcXG6xzuvs4J-wNye2M16bbXBRP3xjFCpKqRRKKP4bAIWn2g</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>Zimmermann, H</creator><creator>Koh, C.H</creator><creator>Degenkolbe, R</creator><creator>O'Connor, M.J</creator><creator>Muller, A</creator><creator>Steger, G</creator><creator>Chen, J.J</creator><creator>Lui, Y</creator><creator>Androphy, E</creator><creator>Bernard, H.U</creator><general>Soc General Microbiol</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20001101</creationdate><title>Interaction with CBP/p300 enables the bovine papillomavirus type 1 E6 oncoprotein to downregulate CBP/p300-mediated transactivation by p53</title><author>Zimmermann, H ; Koh, C.H ; Degenkolbe, R ; O'Connor, M.J ; Muller, A ; Steger, G ; Chen, J.J ; Lui, Y ; Androphy, E ; Bernard, H.U</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-c4f7a37ebf2a64afa80edc92fb3682e2f906fa9a2e14f310b7d8b3be31e17e843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Bovine papillomavirus 1</topic><topic>Bovine papillomavirus 1 - genetics</topic><topic>Cattle</topic><topic>CBP protein</topic><topic>Cell Line</topic><topic>Cell Transformation, Viral</topic><topic>Down-Regulation</topic><topic>E6 protein</topic><topic>Gene Expression Regulation, Viral</topic><topic>Genes, p53</topic><topic>Humans</topic><topic>mutants</topic><topic>Nuclear Proteins - genetics</topic><topic>oncogene proteins</topic><topic>Oncogene Proteins, Viral - genetics</topic><topic>p300 protein</topic><topic>p53 protein</topic><topic>Trans-Activators - genetics</topic><topic>transactivators</topic><topic>transcription (genetics)</topic><topic>Transcriptional Activation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zimmermann, H</creatorcontrib><creatorcontrib>Koh, C.H</creatorcontrib><creatorcontrib>Degenkolbe, R</creatorcontrib><creatorcontrib>O'Connor, M.J</creatorcontrib><creatorcontrib>Muller, A</creatorcontrib><creatorcontrib>Steger, G</creatorcontrib><creatorcontrib>Chen, J.J</creatorcontrib><creatorcontrib>Lui, Y</creatorcontrib><creatorcontrib>Androphy, E</creatorcontrib><creatorcontrib>Bernard, H.U</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zimmermann, H</au><au>Koh, C.H</au><au>Degenkolbe, R</au><au>O'Connor, M.J</au><au>Muller, A</au><au>Steger, G</au><au>Chen, J.J</au><au>Lui, Y</au><au>Androphy, E</au><au>Bernard, H.U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction with CBP/p300 enables the bovine papillomavirus type 1 E6 oncoprotein to downregulate CBP/p300-mediated transactivation by p53</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>2000-11-01</date><risdate>2000</risdate><volume>81</volume><issue>11</issue><spage>2617</spage><epage>2623</epage><pages>2617-2623</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><abstract>The E6 oncoprotein of bovine papillomavirus type 1 (BPV-1) can transform cells independently of p53 degradation. The precise mechanisms underlying this transformation are not yet completely understood. Here it is shown that BPV-1 E6 interacts with CBP/p300 in the same way as described for the E6 proteins of oncogenic human papillomaviruses. This interaction results in an inhibition of the transcriptional coactivator function of CBP/p300 required by p53 and probably by other transcription factors. The comparison of the CBP/p300-binding properties of BPV-1 E6 mutants previously characterized in transcription and transformation studies suggests (i) that the E6-CBP/p300 interaction may be necessary, but not sufficient, for cell transformation, and (ii) that the transcriptional activator function, inherent to the E6 protein, is not derived from forming a complex with CBP/p300.</abstract><cop>England</cop><pub>Soc General Microbiol</pub><pmid>11038372</pmid><doi>10.1099/0022-1317-81-11-2617</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Microbiology Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Bovine papillomavirus 1 Bovine papillomavirus 1 - genetics Cattle CBP protein Cell Line Cell Transformation, Viral Down-Regulation E6 protein Gene Expression Regulation, Viral Genes, p53 Humans mutants Nuclear Proteins - genetics oncogene proteins Oncogene Proteins, Viral - genetics p300 protein p53 protein Trans-Activators - genetics transactivators transcription (genetics) Transcriptional Activation |
| title | Interaction with CBP/p300 enables the bovine papillomavirus type 1 E6 oncoprotein to downregulate CBP/p300-mediated transactivation by p53 |
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