Chronic Myocarditis Induced by T Cells Reactive to a Single Cardiac Myosin Peptide: Persistent Inflammation, Cardiac Dilatation, Myocardial Scarring and Continuous Myocyte Apoptosis

Recent recognition that an autoimmune myocarditis may precede, and result in, dilated cardiomyopathy has focused attention on immune mechanisms of myocardial injury. In this paper, we describe a model of chronic autoimmune myocarditis in the Lewis rat. The production of myocarditis has been previous...

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Veröffentlicht in:	Journal of autoimmunity 2000-11, Vol.15 (3), p.359-367
Hauptverfasser:	Ratcliffe, Nora R, Hutchins, John, Barry, Brenda, Hickey, William F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Apoptosis - immunology Autoimmune Diseases - immunology Autoimmune Diseases - pathology autoimmunity, myocarditis, apoptosis, cardiomyopathy, T cell, myosin Biological and medical sciences Cardiology. Vascular system Cardiomyopathy, Dilated - immunology CD4-Positive T-Lymphocytes - immunology Cells, Cultured Chronic Disease Disease Models, Animal Experimental and animal immunopathology. Animal models Heart Immunopathology Intercellular Adhesion Molecule-1 - metabolism Lymphocyte Activation - immunology Macrophage-1 Antigen - metabolism Medical sciences Myocarditis - immunology Myocarditis - pathology Myocarditis. Cardiomyopathies Myocardium - cytology myosin Myosins - immunology Peptide Fragments - immunology Peptides - immunology Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Rats Rats, Inbred Lew T-Lymphocytes - cytology T-Lymphocytes - immunology
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