CD95/CD95 Ligand Interactions on Epithelial Cells in Host Defense to Pseudomonas aeruginosa

Pseudomonas aeruginosa causes severe infections, particularly of the lung, that are life threatening. Here, we show that P. aeruginosa infection induces apoptosis of lung epithelial cells by activation of the endogenous CD95/CD95 ligand system. Deficiency of CD95 or CD95 ligand on epithelial cells p...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2000-10, Vol.290 (5491), p.527-530
Hauptverfasser:	Grassmé, Heike, Kirschnek, Susanne, Riethmueller, Joachim, Riehle, Andrea, von Kürthy, Gabriele, Lang, Florian, Weller, Michael, Gulbins, Erich
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bacteria Bacterial diseases Biological and medical sciences Bone Marrow Transplantation CD95 antigen CD95L protein Cell death Cell Line Epithelial cells Epithelial Cells - immunology Epithelial Cells - microbiology Epithelial Cells - pathology Experimental bacterial diseases and models Fas Ligand Protein fas Receptor - genetics fas Receptor - metabolism Fibroblasts Genetic mutation Humans In Situ Nick-End Labeling Infections Infectious diseases Ligands Ligands (Biochemistry) Lung - immunology Lung - microbiology Lung - pathology Lung Diseases - immunology Lung Diseases - microbiology Lung Diseases - pathology Lungs Medical sciences Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Inbred C3H Pseudomonas aeruginosa Pseudomonas aeruginosa - immunology Pseudomonas aeruginosa - pathogenicity Pseudomonas Infections - immunology Pseudomonas Infections - microbiology Pseudomonas Infections - pathology Sepsis Sepsis - microbiology Spleen - microbiology
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