E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice

Background & Aims: Inactivation of the adenomatous polyposis coli (APC) gene is observed at early stages of intestinal tumor formation, whereas loss of E-cadherin is usually associated with tumor progression. Because both proteins compete for the binding to β-catenin, an essential component of t...

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