Value of p63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis of poorly differentiated and undifferentiated carcinomas

To facilitate the differential diagnosis of poorly differentiated metastatic carcinomas of unknown primary site, we evaluated p63 and cytokeratin (CK) 5/6 as immunohistochemical markers for squamous cell carcinomas. The study cases were as follows: squamous cell carcinoma of the lungs, head/neck, es...

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Veröffentlicht in:	American journal of clinical pathology 2001-12, Vol.116 (6), p.823-830
Hauptverfasser:	KAUFMANN, Olaf, FIETZE, Ellen, MENGS, Jörg, DIETEL, Manfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - secondary Diagnosis, Differential DNA-Binding Proteins Female Genes, Tumor Suppressor Humans Immunoenzyme Techniques Investigative techniques, diagnostic techniques (general aspects) Keratin-5 Keratins - analysis Male Medical sciences Membrane Proteins Miscellaneous. Technology Neoplasms, Unknown Primary - chemistry Neoplasms, Unknown Primary - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phosphoproteins - analysis Reproducibility of Results Sensitivity and Specificity Trans-Activators - analysis Transcription Factors Tumor Suppressor Proteins
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