The autoimmune pathogenesis of rheumatoid arthritis: Role of autoreactive T cells and new immunotherapies

Objectives: To review the role of T lymphocytes in the pathogenesis of rheumatoid arthritis (RA) and discuss the relevance of the components of the trimolecular complex (synovial T cells, autoantigens, and antigen presenting cells) in the pathogenic autoimmune response in RA. Methods: Currently avai...

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Veröffentlicht in:	Seminars in arthritis and rheumatism 2001-12, Vol.31 (3), p.160-175
Hauptverfasser:	VanderBorght, Ann, Geusens, Piet, Raus, Jef, Stinissen, Piet
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - therapy Autoantigens Autoimmunity Biological and medical sciences Diseases of the osteoarticular system Humans immunotherapies Immunotherapy Inflammatory joint diseases Medical sciences pathogenesis Receptors, Antigen, T-Cell - biosynthesis Rheumatoid arthritis Synovial Membrane - cytology Synovial Membrane - immunology Synovial Membrane - metabolism T cells T-Lymphocytes - immunology trimolecular complex
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