Two cis-acting elements in the 3′ untranslated region of α-CaMKII regulate its dendritic targeting

Dendritic localization of the α subunit of Ca 2+ /calmodulin-dependent protein kinase II (αCaMKII) mRNA in CNS neurons requires its 3′ untranslated region (3′UTR). We investigated this targeting mechanism by identifying two cis-acting elements in the 3′UTR. One is a 30-nucleotide element that mediat...

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Veröffentlicht in:	Nature neuroscience 2000-11, Vol.3 (11), p.1079-1084
Hauptverfasser:	Mori, Yasutake, Imaizumi, Kazunori, Katayama, Taiichi, Yoneda, Takunari, Tohyama, Masaya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Base Sequence - genetics Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - genetics Calmodulin-Binding Proteins - genetics Calmodulin-Binding Proteins - metabolism Cells, Cultured Cellular signal transduction Cloning, Molecular - methods Dendrites - genetics Dendrites - metabolism Embryo, Mammalian Gene Expression Profiling - methods Hippocampus Memory - physiology Molecular Sequence Data Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurobiology Neurogranin Neurons Neurosciences Physiological aspects Protein biosynthesis Rats Rats, Wistar RNA, Messenger - genetics
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