Evaluation of coagulation in pediatric bone marrow transplantation patients
: A hypercoagulable state is frequently described in adult patients undergoing bone marrow transplantation (BMT). In this study, the coagulation profile of 29 children was prospectively investigated in the pre‐ and post‐transplant period. A significant rise in the activated partial thromboplastin ti...
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| Veröffentlicht in: | Pediatric transplantation 2001-12, Vol.5 (6), p.430-433 |
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| container_title | Pediatric transplantation |
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| creator | Yenicesu, İdil Uçkan, Duygu Çetin, Mualla Tuncer, A. M. Tezcan, İlhan Gürgey, Aytemiz |
| description | : A hypercoagulable state is frequently described in adult patients undergoing bone marrow transplantation (BMT). In this study, the coagulation profile of 29 children was prospectively investigated in the pre‐ and post‐transplant period. A significant rise in the activated partial thromboplastin time (aPTT) values was detected on days 7 and 14 after transplantation. Moreover, an increase in the d‐dimer level was also notable, regardless of the clinical condition of the patients. The other coagulation parameters investigated (i.e. protein S, protein C, anti‐thrombin III, factor VIII, von Willebrand factor, and prothrombin time) remained essentially unchanged. However, hyper‐fibrinogenemia was observed in all patients with chronic myeloid leukemia (CML) (n=5) before and after transplantation. In summary, in the present study pediatric bone marrow transplantation patients did not show a hyper‐coagulable state after marrow infusion. However, a significant rise in PTT and d‐dimer values were noted. |
| doi_str_mv | 10.1034/j.1399-3046.2001.t01-1-00036.x |
| format | Article |
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M. ; Tezcan, İlhan ; Gürgey, Aytemiz</creator><creatorcontrib>Yenicesu, İdil ; Uçkan, Duygu ; Çetin, Mualla ; Tuncer, A. M. ; Tezcan, İlhan ; Gürgey, Aytemiz</creatorcontrib><description>: A hypercoagulable state is frequently described in adult patients undergoing bone marrow transplantation (BMT). In this study, the coagulation profile of 29 children was prospectively investigated in the pre‐ and post‐transplant period. A significant rise in the activated partial thromboplastin time (aPTT) values was detected on days 7 and 14 after transplantation. Moreover, an increase in the d‐dimer level was also notable, regardless of the clinical condition of the patients. The other coagulation parameters investigated (i.e. protein S, protein C, anti‐thrombin III, factor VIII, von Willebrand factor, and prothrombin time) remained essentially unchanged. However, hyper‐fibrinogenemia was observed in all patients with chronic myeloid leukemia (CML) (n=5) before and after transplantation. In summary, in the present study pediatric bone marrow transplantation patients did not show a hyper‐coagulable state after marrow infusion. However, a significant rise in PTT and d‐dimer values were noted.</description><identifier>ISSN: 1397-3142</identifier><identifier>EISSN: 1399-3046</identifier><identifier>DOI: 10.1034/j.1399-3046.2001.t01-1-00036.x</identifier><identifier>PMID: 11737768</identifier><language>eng</language><publisher>Copenhagen, Denmark: Munksgaard International Publishers</publisher><subject>Adolescent ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Coagulation ; BMT ; Bone Marrow Transplantation - physiology ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Child ; Child, Preschool ; childhood ; coagulation ; Female ; Fibrin Fibrinogen Degradation Products - analysis ; Humans ; Infant ; Male ; Medical sciences ; Partial Thromboplastin Time ; Prospective Studies ; Protein C - analysis ; Protein S - analysis ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>Pediatric transplantation, 2001-12, Vol.5 (6), p.430-433</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4516-1afc69392a8a003a6037eb9857a30b866cde376ba6000aed56b005d123980e73</citedby><cites>FETCH-LOGICAL-c4516-1afc69392a8a003a6037eb9857a30b866cde376ba6000aed56b005d123980e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1399-3046.2001.t01-1-00036.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1399-3046.2001.t01-1-00036.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1416,23921,23922,25131,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14167593$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11737768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yenicesu, İdil</creatorcontrib><creatorcontrib>Uçkan, Duygu</creatorcontrib><creatorcontrib>Çetin, Mualla</creatorcontrib><creatorcontrib>Tuncer, A. M.</creatorcontrib><creatorcontrib>Tezcan, İlhan</creatorcontrib><creatorcontrib>Gürgey, Aytemiz</creatorcontrib><title>Evaluation of coagulation in pediatric bone marrow transplantation patients</title><title>Pediatric transplantation</title><addtitle>Pediatr Transplant</addtitle><description>: A hypercoagulable state is frequently described in adult patients undergoing bone marrow transplantation (BMT). In this study, the coagulation profile of 29 children was prospectively investigated in the pre‐ and post‐transplant period. A significant rise in the activated partial thromboplastin time (aPTT) values was detected on days 7 and 14 after transplantation. Moreover, an increase in the d‐dimer level was also notable, regardless of the clinical condition of the patients. The other coagulation parameters investigated (i.e. protein S, protein C, anti‐thrombin III, factor VIII, von Willebrand factor, and prothrombin time) remained essentially unchanged. However, hyper‐fibrinogenemia was observed in all patients with chronic myeloid leukemia (CML) (n=5) before and after transplantation. In summary, in the present study pediatric bone marrow transplantation patients did not show a hyper‐coagulable state after marrow infusion. However, a significant rise in PTT and d‐dimer values were noted.</description><subject>Adolescent</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation</subject><subject>BMT</subject><subject>Bone Marrow Transplantation - physiology</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>childhood</subject><subject>coagulation</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - analysis</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Partial Thromboplastin Time</subject><subject>Prospective Studies</subject><subject>Protein C - analysis</subject><subject>Protein S - analysis</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>1397-3142</issn><issn>1399-3046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMFu1DAQhi0EoqXwCigXeksYx46dXJDQalmqVoBgpUpcRhPHQV6ySbATun17vM2qPXOasebz7_HH2CWHjIOQ73cZF1WVCpAqywF4NgFPeQoAQmWHZ-z8cfz8odep4DI_Y69C2EVcyVK-ZGeca6G1Ks_Z9fovdTNNbuiToU3MQL_mbjm6Phlt42jyziT10NtkT94Pd8nkqQ9jR_20gGMstp_Ca_aipS7YN6d6wbaf1tvV5_Tm6-Zq9fEmNbLgKuXUGlWJKqeS4tqkQGhbV2WhSUBdKmUaK7Sq4wCAbFOoGqBoeC6qEqwWF-xyiR398Ge2YcK9C8Z2cSE7zAF1LqTmICP4YQGNH0LwtsXRu_iHe-SAR5u4w6MuPOrCo02MNpHjg008xIC3p5fmem-bp-snfRF4dwIoGOraKMa48MRJrnRRicitFu7Odfb-P9fAb-vt99jFlHRJcWGyh8cU8r9RxYUKvP2yQXX7Q2zU9icW4h_SFqJc</recordid><startdate>200112</startdate><enddate>200112</enddate><creator>Yenicesu, İdil</creator><creator>Uçkan, Duygu</creator><creator>Çetin, Mualla</creator><creator>Tuncer, A. M.</creator><creator>Tezcan, İlhan</creator><creator>Gürgey, Aytemiz</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200112</creationdate><title>Evaluation of coagulation in pediatric bone marrow transplantation patients</title><author>Yenicesu, İdil ; Uçkan, Duygu ; Çetin, Mualla ; Tuncer, A. M. ; Tezcan, İlhan ; Gürgey, Aytemiz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4516-1afc69392a8a003a6037eb9857a30b866cde376ba6000aed56b005d123980e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation</topic><topic>BMT</topic><topic>Bone Marrow Transplantation - physiology</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>childhood</topic><topic>coagulation</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - analysis</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Partial Thromboplastin Time</topic><topic>Prospective Studies</topic><topic>Protein C - analysis</topic><topic>Protein S - analysis</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yenicesu, İdil</creatorcontrib><creatorcontrib>Uçkan, Duygu</creatorcontrib><creatorcontrib>Çetin, Mualla</creatorcontrib><creatorcontrib>Tuncer, A. M.</creatorcontrib><creatorcontrib>Tezcan, İlhan</creatorcontrib><creatorcontrib>Gürgey, Aytemiz</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yenicesu, İdil</au><au>Uçkan, Duygu</au><au>Çetin, Mualla</au><au>Tuncer, A. M.</au><au>Tezcan, İlhan</au><au>Gürgey, Aytemiz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of coagulation in pediatric bone marrow transplantation patients</atitle><jtitle>Pediatric transplantation</jtitle><addtitle>Pediatr Transplant</addtitle><date>2001-12</date><risdate>2001</risdate><volume>5</volume><issue>6</issue><spage>430</spage><epage>433</epage><pages>430-433</pages><issn>1397-3142</issn><eissn>1399-3046</eissn><abstract>: A hypercoagulable state is frequently described in adult patients undergoing bone marrow transplantation (BMT). In this study, the coagulation profile of 29 children was prospectively investigated in the pre‐ and post‐transplant period. A significant rise in the activated partial thromboplastin time (aPTT) values was detected on days 7 and 14 after transplantation. Moreover, an increase in the d‐dimer level was also notable, regardless of the clinical condition of the patients. The other coagulation parameters investigated (i.e. protein S, protein C, anti‐thrombin III, factor VIII, von Willebrand factor, and prothrombin time) remained essentially unchanged. However, hyper‐fibrinogenemia was observed in all patients with chronic myeloid leukemia (CML) (n=5) before and after transplantation. In summary, in the present study pediatric bone marrow transplantation patients did not show a hyper‐coagulable state after marrow infusion. However, a significant rise in PTT and d‐dimer values were noted.</abstract><cop>Copenhagen, Denmark</cop><pub>Munksgaard International Publishers</pub><pmid>11737768</pmid><doi>10.1034/j.1399-3046.2001.t01-1-00036.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Coagulation BMT Bone Marrow Transplantation - physiology Bone marrow, stem cells transplantation. Graft versus host reaction Child Child, Preschool childhood coagulation Female Fibrin Fibrinogen Degradation Products - analysis Humans Infant Male Medical sciences Partial Thromboplastin Time Prospective Studies Protein C - analysis Protein S - analysis Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Evaluation of coagulation in pediatric bone marrow transplantation patients |
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