Lactosylceramide Mediates Shear-Induced Endothelial Superoxide Production and Intercellular Adhesion Molecule-1 Expression

Laminar shear stress activates NADPH oxidase in vascular endothelial cells (ECs), and the generated superoxide radicals (O 2 – ·) are known to be involved in intercellular adhesion molecule (ICAM)-1 expression. In this study, the role of a glycosphingolipid (GSL), lactosylceramide (LacCer), as a sec...

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Veröffentlicht in:	Journal of vascular research 2001-11, Vol.38 (6), p.551-559
Hauptverfasser:	Yeh, Li-Hong, Kinsey, Adam M., Chatterjee, Subroto, Alevriadou, B. Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD Biological and medical sciences Blood vessels and receptors Cells, Cultured Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Galactosyltransferases - metabolism Humans Intercellular Adhesion Molecule-1 - metabolism Lactosylceramides - pharmacology Morpholines - pharmacology Research Paper Stress, Mechanical Superoxides - metabolism Vertebrates: cardiovascular system
Online-Zugang:	Volltext
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