Advances in Uterine Leiomyoma Research: The Progesterone Hypothesis

Uterine leiomyomas are monoclonal tumors. However, the factors involved in their initiation and growth remain poorly understood. The neoplastic transformation of myometrium to leiomyoma likely involves somatic mutations of normal myometrium and the complex interactions of sex steroids and local grow...

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Veröffentlicht in:	Environmental health perspectives 2000-10, Vol.108 (s5), p.791-793
1. Verfasser:	Rein, Mitchell S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Biochemistry Cell Transformation, Neoplastic - genetics Estrogens Female Gonadal Steroid Hormones - physiology Growth promotion Growth Substances - physiology Humans Leiomyoma Leiomyoma - etiology Mechanisms of Tumor Development: Hormones and Growth Factors Mitosis - physiology Mutation - genetics Myoma Myometrium Pathogenesis Progesterone - physiology Progesterone receptors Progestins - physiology Receptors, Progesterone - physiology Somatic mutation Uterine Neoplasms - etiology
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