Disruption of Neutrophil Migration in a Conditional Transgenic Model: Evidence for CXCR2 Desensitization In Vivo

We developed transgenic mice conditionally expressing the neutrophil chemoattracting chemokine KC and the beta-galactosidase gene in multiple tissues. In these transgenic mice, doxycycline treatment induced a strong up-regulation in the expression of KC in several tissues, including heart, liver, ki...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-12, Vol.167 (12), p.7102-7110
Hauptverfasser:	Wiekowski, Maria T, Chen, Shu-Cheng, Zalamea, Petronio, Wilburn, Brian P, Kinsley, David J, Sharif, Wanda W, Jensen, Kristian K, Hedrick, Joseph A, Manfra, Denise, Lira, Sergio A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology beta-Galactosidase - genetics beta-Galactosidase - metabolism Calcium - metabolism Chemokine CXCL1 chemokine KC Chemokines, CXC Chemotactic Factors - genetics Chemotactic Factors - physiology Chemotaxis, Leukocyte CXCR2 protein Down-Regulation Doxycycline - pharmacology Flow Cytometry Genes, Reporter Growth Substances - genetics Growth Substances - physiology Intercellular Signaling Peptides and Proteins L-Selectin - metabolism Mice Mice, Transgenic Neutrophils - immunology Receptors, Interleukin-8B - metabolism RNA, Messenger - biosynthesis Skin Transplantation - immunology Skin Transplantation - pathology Tissue Distribution
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