Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fcgamma receptor signalling during phagocytosis

Phagocytosis by macrophages and neutrophils involves the spatial and temporal reorganisation of the actin-based cytoskeleton at sites of particle ingestion. Local polymerisation of actin filaments supports the protrusion of pseudopodia that eventually engulf the particle. Here we have investigated i...

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Veröffentlicht in:	Journal of cell science 2001-12, Vol.114 (Pt 23), p.4307-4318
Hauptverfasser:	Coppolino, M G, Krause, M, Hagendorff, P, Monner, D A, Trimble, W, Grinstein, S, Wehland, J, Sechi, A S
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adaptor Proteins, Signal Transducing Animals Carrier Proteins - genetics Carrier Proteins - metabolism Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Cycle Proteins Cell Line Cells, Cultured Cytoskeleton - metabolism Humans Macrophages - cytology Macrophages - metabolism Macrophages - physiology Membrane Proteins - genetics Membrane Proteins - metabolism Mice Microfilament Proteins - genetics Microfilament Proteins - metabolism Monocytes - cytology Monocytes - metabolism Oncogene Proteins - metabolism Phagocytosis - physiology Phagosomes - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Proteins - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-vav Receptors, IgG - metabolism rho GTP-Binding Proteins - metabolism Signal Transduction Wiskott-Aldrich Syndrome Protein
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