Activated platelets adherent to an intact endothelial cell monolayer bind flowing neutrophils and enable them to transfer to the endothelial surface

We have investigated the role that platelets may play in promoting adhesion of neutrophils to morphologically intact endothelium. Immortalized human microvascular endothelial cells (HMEC-1) were grown to confluence in a glass capillary (microslide) and incorporated in a flow-based assay that allowed...

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Veröffentlicht in:	The Journal of laboratory and clinical medicine 2000-10, Vol.136 (4), p.303-313
Hauptverfasser:	Kirton, Christopher M., Nash, Gerard B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Monoclonal Biological and medical sciences Blood Platelets - cytology CD18 Antigens - immunology CD18 Antigens - metabolism Cell Adhesion - drug effects Cell Adhesion - immunology Cell Communication - immunology Cell Line, Transformed Endothelium, Vascular - cytology Hematology Humans Investigative techniques, diagnostic techniques (general aspects) Lymphocyte Function-Associated Antigen-1 - immunology Lymphocyte Function-Associated Antigen-1 - metabolism Macrophage-1 Antigen - immunology Macrophage-1 Antigen - metabolism Medical sciences N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutralization Tests Neutrophils - cytology Neutrophils - metabolism P-Selectin - immunology P-Selectin - metabolism Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Platelet Adhesiveness - physiology
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