Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages

Members of the polo subfamily of protein kinases play crucial roles in cell proliferation. To study the function of this family in more detail, we isolated the cDNA of human Fnk (FGF-inducible kinase) which codes for a serine/threonine kinase of 646 aa. Despite the homology to the proliferation-asso...

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Veröffentlicht in:	Oncogene 2000-10, Vol.19 (42), p.4832-4839
Hauptverfasser:	HOLTRICH, Uwe, WOLF, Georg, KUHL, Dietmar, STREBHARDT, Klaus, JUPING YUAN, BEREITER-HAHN, Jürgen, KARN, Thomas, WEILER, Markus, KAUSELMANN, Gunther, REHLI, Michael, ANDREESEN, Reinhard, KAUFMANN, Manfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Adult Animals Biological and medical sciences Blood cells Blood Cells - cytology Blood Cells - drug effects Blood Cells - enzymology Calcineurin Calcineurin - chemistry Calcium - physiology Calcium-binding protein Calcium-Binding Proteins Calmodulin Calmodulin - chemistry Carrier Proteins - chemistry Carrier Proteins - metabolism Cell adhesion Cell Adhesion - drug effects Cell Adhesion - genetics Cell culture Cell Cycle Proteins Cell Differentiation Cell growth Cell Membrane - enzymology Cell membranes Cell proliferation Chlorocebus aethiops Cib protein COS Cells Culture Media - pharmacology Culture Media, Serum-Free - pharmacology Cytoskeleton - metabolism Cytoskeleton - ultrastructure DNA, Complementary - genetics Fnk gene Fnk protein Fundamental and applied biological sciences. Psychology Fusion protein Gene expression Gene Expression Regulation, Developmental Genes. Genome HL-60 Cells Homology Humans Immunoprecipitation Kinases Macrophages Macrophages - drug effects Macrophages - enzymology Mammalian cells Molecular and cellular biology Molecular genetics Monocytes Monocytes - cytology Monocytes - drug effects Monocytes - enzymology Multigene Family Peripheral blood Polo-like kinase Polo-Like Kinase 1 Polymerase Chain Reaction Protein Kinases - classification Protein Kinases - genetics Protein Serine-Threonine Kinases - biosynthesis Protein Serine-Threonine Kinases - genetics Protein-serine/threonine kinase Proteins Proto-Oncogene Proteins Recombinant Fusion Proteins - physiology RNA, Messenger - biosynthesis Signal Transduction Transcription Transcription, Genetic Transfection Tumor Suppressor Proteins Two-Hybrid System Techniques U937 Cells
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