Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions
Abnormalities in the cell cycle are associated with tumorigenesis but have not yet been identified in squamous cell carcinoma (SCC) of the vulva or in adjacent vulvar lesions. The purpose of this study was to identify cell cycle protein expression (cyclin D1 and retinoblastoma protein [pRb]) in vulv...
Gespeichert in:
| Veröffentlicht in: | International journal of gynecological cancer 2001-09, Vol.11 (5), p.381-386 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 386 |
|---|---|
| container_issue | 5 |
| container_start_page | 381 |
| container_title | International journal of gynecological cancer |
| container_volume | 11 |
| creator | Rolfe, K. J. Crow, J. C. Benjamin, E. Reid, W. M. N. Maclean, A. B. Perrett, C. W. |
| description | Abnormalities in the cell cycle are associated with tumorigenesis but have not yet been identified in squamous cell carcinoma (SCC) of the vulva or in adjacent vulvar lesions. The purpose of this study was to identify cell cycle protein expression (cyclin D1 and retinoblastoma protein [pRb]) in vulvar SCC and in adjacent potentially premalignant lesions: lichen sclerosis (LS), squamous cell hyperplasia (SH), and vulvar intraepithelial neoplasia (VIN). Using immunohistochemical techniques, 57 SCCs were analyzed with 19 adjacent areas showing LS, 13 showing SH, 11 VIN, and six normal epithelium. Fifty-one percent of SCCs showed abnormal cyclin D1 expression and 37% showed abnormal pRb. Abnormal cyclin D1 expression in the adjacent areas was as follows: 53% in LS, 31% in SH, 18% in VIN, and 0% in normal. Abnormal pRb expression was as follows: 42% in LS, 62% in SH, 46% in VIN, and 33% in normal. Only 10 lesions showed abnormal expression of both proteins. Abnormal expression of cyclin D1 in SCC was statistically significant compared with adjacent normal epithelium. In SCC lesions, abnormal cyclin D1 expression was associated with greater depth of invasion. Abnormal pRb in SCC was associated with poor tumor grade. Cyclin D1 and pRb are separately involved in the progression of vulvar cancer, and changes in the expression of these proteins may represent an early stage of malignant transformation in vulvar disease. |
| doi_str_mv | 10.1136/ijgc-00009577-200109000-00007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72341900</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1048891X24145197</els_id><sourcerecordid>72341900</sourcerecordid><originalsourceid>FETCH-LOGICAL-b2499-1dc0608c67bfc2ad3288ab6d278706c47f8a9dce7d0b855836da1eae2b6db8173</originalsourceid><addsrcrecordid>eNqVkMtKAzEUhoMotlZfQQZEd6NJ5pJk4UKqVqXgRsFdyCSnkmEuNZkp9O1NO1XBlYZAkpMvOT8fQucEXxKS5Fe2fNcxDkNkjMUUY4JFOG1LbA-NSUazmKQJ3w97nPKYC_I2Qkfel5tHFItDNCKEJSzNxRg9Tde6sk10SyLVmMhBZ5u2qJTv2lpFS9d2EG7DXPXVSrlIq0aD27LKlEpD00UVeNs2_hgdLFTl4WS3TtDr_d3L9CGeP88epzfzuKCpEDExGueY65wVC02VSSjnqsgNZZzhXKdswZUwGpjBBc8ynuRGEVBAA1PwEHyCLoZ_Q7qPHnwna-s1VJVqoO29ZDRJSXASwLNfYNn2rgnZJM0yykRGttT1QGnXeu9gIZfO1sqtJcFyo1xulMsv5fJb-ba0iXO669IXNZif1zvHAZgNAAQpKwtOem0haDTWge6kae2fW_Hhp6Iu_5nyE8vpo2E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2552795100</pqid></control><display><type>article</type><title>Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Rolfe, K. J. ; Crow, J. C. ; Benjamin, E. ; Reid, W. M. N. ; Maclean, A. B. ; Perrett, C. W.</creator><creatorcontrib>Rolfe, K. J. ; Crow, J. C. ; Benjamin, E. ; Reid, W. M. N. ; Maclean, A. B. ; Perrett, C. W.</creatorcontrib><description>Abnormalities in the cell cycle are associated with tumorigenesis but have not yet been identified in squamous cell carcinoma (SCC) of the vulva or in adjacent vulvar lesions. The purpose of this study was to identify cell cycle protein expression (cyclin D1 and retinoblastoma protein [pRb]) in vulvar SCC and in adjacent potentially premalignant lesions: lichen sclerosis (LS), squamous cell hyperplasia (SH), and vulvar intraepithelial neoplasia (VIN). Using immunohistochemical techniques, 57 SCCs were analyzed with 19 adjacent areas showing LS, 13 showing SH, 11 VIN, and six normal epithelium. Fifty-one percent of SCCs showed abnormal cyclin D1 expression and 37% showed abnormal pRb. Abnormal cyclin D1 expression in the adjacent areas was as follows: 53% in LS, 31% in SH, 18% in VIN, and 0% in normal. Abnormal pRb expression was as follows: 42% in LS, 62% in SH, 46% in VIN, and 33% in normal. Only 10 lesions showed abnormal expression of both proteins. Abnormal expression of cyclin D1 in SCC was statistically significant compared with adjacent normal epithelium. In SCC lesions, abnormal cyclin D1 expression was associated with greater depth of invasion. Abnormal pRb in SCC was associated with poor tumor grade. Cyclin D1 and pRb are separately involved in the progression of vulvar cancer, and changes in the expression of these proteins may represent an early stage of malignant transformation in vulvar disease.</description><identifier>ISSN: 1048-891X</identifier><identifier>EISSN: 1525-1438</identifier><identifier>DOI: 10.1136/ijgc-00009577-200109000-00007</identifier><identifier>PMID: 11737469</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cancer ; Carcinoma in Situ - metabolism ; Carcinoma in Situ - pathology ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Case-Control Studies ; Cell Cycle ; Cell Transformation, Neoplastic - metabolism ; Cyclin D1 ; Cyclin D1 - metabolism ; Female ; Genital cancers ; Humans ; Hyperplasia - metabolism ; Hyperplasia - pathology ; Immunohistochemistry ; Lichen Sclerosus et Atrophicus - metabolism ; Lichen Sclerosus et Atrophicus - pathology ; Middle Aged ; Neoplasm Staging ; Proteins ; Retina ; Retinoblastoma ; Retinoblastoma protein ; Retinoblastoma Protein - metabolism ; Squamous cell carcinoma ; Tumors ; Vulvar cancer ; Vulvar Neoplasms - metabolism ; Vulvar Neoplasms - pathology</subject><ispartof>International journal of gynecological cancer, 2001-09, Vol.11 (5), p.381-386</ispartof><rights>2001 IGCS</rights><rights>2001 IGCS and ESGO.</rights><rights>2001 2001 IGCS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-b2499-1dc0608c67bfc2ad3288ab6d278706c47f8a9dce7d0b855836da1eae2b6db8173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27906,27907</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11737469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rolfe, K. J.</creatorcontrib><creatorcontrib>Crow, J. C.</creatorcontrib><creatorcontrib>Benjamin, E.</creatorcontrib><creatorcontrib>Reid, W. M. N.</creatorcontrib><creatorcontrib>Maclean, A. B.</creatorcontrib><creatorcontrib>Perrett, C. W.</creatorcontrib><title>Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions</title><title>International journal of gynecological cancer</title><addtitle>Int J Gynecol Cancer</addtitle><description>Abnormalities in the cell cycle are associated with tumorigenesis but have not yet been identified in squamous cell carcinoma (SCC) of the vulva or in adjacent vulvar lesions. The purpose of this study was to identify cell cycle protein expression (cyclin D1 and retinoblastoma protein [pRb]) in vulvar SCC and in adjacent potentially premalignant lesions: lichen sclerosis (LS), squamous cell hyperplasia (SH), and vulvar intraepithelial neoplasia (VIN). Using immunohistochemical techniques, 57 SCCs were analyzed with 19 adjacent areas showing LS, 13 showing SH, 11 VIN, and six normal epithelium. Fifty-one percent of SCCs showed abnormal cyclin D1 expression and 37% showed abnormal pRb. Abnormal cyclin D1 expression in the adjacent areas was as follows: 53% in LS, 31% in SH, 18% in VIN, and 0% in normal. Abnormal pRb expression was as follows: 42% in LS, 62% in SH, 46% in VIN, and 33% in normal. Only 10 lesions showed abnormal expression of both proteins. Abnormal expression of cyclin D1 in SCC was statistically significant compared with adjacent normal epithelium. In SCC lesions, abnormal cyclin D1 expression was associated with greater depth of invasion. Abnormal pRb in SCC was associated with poor tumor grade. Cyclin D1 and pRb are separately involved in the progression of vulvar cancer, and changes in the expression of these proteins may represent an early stage of malignant transformation in vulvar disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer</subject><subject>Carcinoma in Situ - metabolism</subject><subject>Carcinoma in Situ - pathology</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Case-Control Studies</subject><subject>Cell Cycle</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Cyclin D1</subject><subject>Cyclin D1 - metabolism</subject><subject>Female</subject><subject>Genital cancers</subject><subject>Humans</subject><subject>Hyperplasia - metabolism</subject><subject>Hyperplasia - pathology</subject><subject>Immunohistochemistry</subject><subject>Lichen Sclerosus et Atrophicus - metabolism</subject><subject>Lichen Sclerosus et Atrophicus - pathology</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Proteins</subject><subject>Retina</subject><subject>Retinoblastoma</subject><subject>Retinoblastoma protein</subject><subject>Retinoblastoma Protein - metabolism</subject><subject>Squamous cell carcinoma</subject><subject>Tumors</subject><subject>Vulvar cancer</subject><subject>Vulvar Neoplasms - metabolism</subject><subject>Vulvar Neoplasms - pathology</subject><issn>1048-891X</issn><issn>1525-1438</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqVkMtKAzEUhoMotlZfQQZEd6NJ5pJk4UKqVqXgRsFdyCSnkmEuNZkp9O1NO1XBlYZAkpMvOT8fQucEXxKS5Fe2fNcxDkNkjMUUY4JFOG1LbA-NSUazmKQJ3w97nPKYC_I2Qkfel5tHFItDNCKEJSzNxRg9Tde6sk10SyLVmMhBZ5u2qJTv2lpFS9d2EG7DXPXVSrlIq0aD27LKlEpD00UVeNs2_hgdLFTl4WS3TtDr_d3L9CGeP88epzfzuKCpEDExGueY65wVC02VSSjnqsgNZZzhXKdswZUwGpjBBc8ynuRGEVBAA1PwEHyCLoZ_Q7qPHnwna-s1VJVqoO29ZDRJSXASwLNfYNn2rgnZJM0yykRGttT1QGnXeu9gIZfO1sqtJcFyo1xulMsv5fJb-ba0iXO669IXNZif1zvHAZgNAAQpKwtOem0haDTWge6kae2fW_Hhp6Iu_5nyE8vpo2E</recordid><startdate>200109</startdate><enddate>200109</enddate><creator>Rolfe, K. J.</creator><creator>Crow, J. C.</creator><creator>Benjamin, E.</creator><creator>Reid, W. M. N.</creator><creator>Maclean, A. B.</creator><creator>Perrett, C. W.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>200109</creationdate><title>Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions</title><author>Rolfe, K. J. ; Crow, J. C. ; Benjamin, E. ; Reid, W. M. N. ; Maclean, A. B. ; Perrett, C. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b2499-1dc0608c67bfc2ad3288ab6d278706c47f8a9dce7d0b855836da1eae2b6db8173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer</topic><topic>Carcinoma in Situ - metabolism</topic><topic>Carcinoma in Situ - pathology</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Case-Control Studies</topic><topic>Cell Cycle</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Cyclin D1</topic><topic>Cyclin D1 - metabolism</topic><topic>Female</topic><topic>Genital cancers</topic><topic>Humans</topic><topic>Hyperplasia - metabolism</topic><topic>Hyperplasia - pathology</topic><topic>Immunohistochemistry</topic><topic>Lichen Sclerosus et Atrophicus - metabolism</topic><topic>Lichen Sclerosus et Atrophicus - pathology</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Proteins</topic><topic>Retina</topic><topic>Retinoblastoma</topic><topic>Retinoblastoma protein</topic><topic>Retinoblastoma Protein - metabolism</topic><topic>Squamous cell carcinoma</topic><topic>Tumors</topic><topic>Vulvar cancer</topic><topic>Vulvar Neoplasms - metabolism</topic><topic>Vulvar Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rolfe, K. J.</creatorcontrib><creatorcontrib>Crow, J. C.</creatorcontrib><creatorcontrib>Benjamin, E.</creatorcontrib><creatorcontrib>Reid, W. M. N.</creatorcontrib><creatorcontrib>Maclean, A. B.</creatorcontrib><creatorcontrib>Perrett, C. W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecological cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rolfe, K. J.</au><au>Crow, J. C.</au><au>Benjamin, E.</au><au>Reid, W. M. N.</au><au>Maclean, A. B.</au><au>Perrett, C. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions</atitle><jtitle>International journal of gynecological cancer</jtitle><addtitle>Int J Gynecol Cancer</addtitle><date>2001-09</date><risdate>2001</risdate><volume>11</volume><issue>5</issue><spage>381</spage><epage>386</epage><pages>381-386</pages><issn>1048-891X</issn><eissn>1525-1438</eissn><abstract>Abnormalities in the cell cycle are associated with tumorigenesis but have not yet been identified in squamous cell carcinoma (SCC) of the vulva or in adjacent vulvar lesions. The purpose of this study was to identify cell cycle protein expression (cyclin D1 and retinoblastoma protein [pRb]) in vulvar SCC and in adjacent potentially premalignant lesions: lichen sclerosis (LS), squamous cell hyperplasia (SH), and vulvar intraepithelial neoplasia (VIN). Using immunohistochemical techniques, 57 SCCs were analyzed with 19 adjacent areas showing LS, 13 showing SH, 11 VIN, and six normal epithelium. Fifty-one percent of SCCs showed abnormal cyclin D1 expression and 37% showed abnormal pRb. Abnormal cyclin D1 expression in the adjacent areas was as follows: 53% in LS, 31% in SH, 18% in VIN, and 0% in normal. Abnormal pRb expression was as follows: 42% in LS, 62% in SH, 46% in VIN, and 33% in normal. Only 10 lesions showed abnormal expression of both proteins. Abnormal expression of cyclin D1 in SCC was statistically significant compared with adjacent normal epithelium. In SCC lesions, abnormal cyclin D1 expression was associated with greater depth of invasion. Abnormal pRb in SCC was associated with poor tumor grade. Cyclin D1 and pRb are separately involved in the progression of vulvar cancer, and changes in the expression of these proteins may represent an early stage of malignant transformation in vulvar disease.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>11737469</pmid><doi>10.1136/ijgc-00009577-200109000-00007</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1048-891X |
| ispartof | International journal of gynecological cancer, 2001-09, Vol.11 (5), p.381-386 |
| issn | 1048-891X 1525-1438 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72341900 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Aged, 80 and over Cancer Carcinoma in Situ - metabolism Carcinoma in Situ - pathology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Case-Control Studies Cell Cycle Cell Transformation, Neoplastic - metabolism Cyclin D1 Cyclin D1 - metabolism Female Genital cancers Humans Hyperplasia - metabolism Hyperplasia - pathology Immunohistochemistry Lichen Sclerosus et Atrophicus - metabolism Lichen Sclerosus et Atrophicus - pathology Middle Aged Neoplasm Staging Proteins Retina Retinoblastoma Retinoblastoma protein Retinoblastoma Protein - metabolism Squamous cell carcinoma Tumors Vulvar cancer Vulvar Neoplasms - metabolism Vulvar Neoplasms - pathology |
| title | Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T10%3A06%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cyclin%20D1%20and%20retinoblastoma%20protein%20in%20vulvar%20cancer%20and%20adjacent%20lesions&rft.jtitle=International%20journal%20of%20gynecological%20cancer&rft.au=Rolfe,%20K.%20J.&rft.date=2001-09&rft.volume=11&rft.issue=5&rft.spage=381&rft.epage=386&rft.pages=381-386&rft.issn=1048-891X&rft.eissn=1525-1438&rft_id=info:doi/10.1136/ijgc-00009577-200109000-00007&rft_dat=%3Cproquest_cross%3E72341900%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2552795100&rft_id=info:pmid/11737469&rft_els_id=S1048891X24145197&rfr_iscdi=true |