Dual role of glucocorticoids in suckling-induced prolactin secretion
The exact contribution of corticosteroids to the control of prolactin secretion in lactating rats is poorly understood. Therefore, the present studies were focused on the effect of adrenalectomy and dexamethasone treatment on the suckling-induced prolactin release. Animals were adrenalectomized on t...
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| Veröffentlicht in: | Endocrine 2001-08, Vol.15 (3), p.287-290 |
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| creator | Horváth, K M Bánky, Z Tóth, B E Nagy, G M Halász, B |
| description | The exact contribution of corticosteroids to the control of prolactin secretion in lactating rats is poorly understood. Therefore, the present studies were focused on the effect of adrenalectomy and dexamethasone treatment on the suckling-induced prolactin release. Animals were adrenalectomized on the 3rd day of lactation and tested on the 7th day of lactation. In adrenalectomized animals, the suckling stimulus failed to induce the characteristic increase in plasma prolactin levels. Dexamethasone pretreatment (400 microg/kg b.w. s.c. 24, 48, 72 h before testing) of adrenalectomized rats restored this prolactin response. The same treatment with dexamethasone given to control animals attenuated the suckling stimulus induced prolactin response. The present findings indicate that corticosteroids are essential for a basic prolactin response of lactating rats. |
| doi_str_mv | 10.1385/ENDO:15:3:287 |
| format | Article |
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Therefore, the present studies were focused on the effect of adrenalectomy and dexamethasone treatment on the suckling-induced prolactin release. Animals were adrenalectomized on the 3rd day of lactation and tested on the 7th day of lactation. In adrenalectomized animals, the suckling stimulus failed to induce the characteristic increase in plasma prolactin levels. Dexamethasone pretreatment (400 microg/kg b.w. s.c. 24, 48, 72 h before testing) of adrenalectomized rats restored this prolactin response. The same treatment with dexamethasone given to control animals attenuated the suckling stimulus induced prolactin response. 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The present findings indicate that corticosteroids are essential for a basic prolactin response of lactating rats.</description><subject>Adrenalectomy</subject><subject>Animals</subject><subject>Animals, Suckling - physiology</subject><subject>Dexamethasone - pharmacology</subject><subject>Feeding Behavior - physiology</subject><subject>Glucocorticoids - physiology</subject><subject>Prolactin - metabolism</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>1355-008X</issn><issn>0969-711X</issn><issn>0969-711X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAQhi0EoqUwsqJMbAHfOYmdbqgpH1JFlw7dLMd2KkMaFzsZ-PekaiWkk97hHr26ewi5B_oETOTPy89qPYd8zuYo-AWZ0rIoUw6wvSRTYHmeUiq2E3IT4xeliFjwazIB4AVyClNSVYNqk-Bbm_gm2bWD9tqH3mnvTExcl8RBf7eu26WuM4O2JjmMsNL9cWV1sL3z3S25alQb7d05Z2Tzutws3tPV-u1j8bJKNYqyT0UhhMgairoWHJDVyLCkXNQmQwGKmXFqULoRWGvR6BotGqbysjS5yIDNyOOpdjzhZ7Cxl3sXtW1b1Vk_RMmRZeNnfATTE6iDjzHYRh6C26vwK4HKozV5tCYhl0yO1kb-4Vw81Htr_umzJvYHXQxoew</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>Horváth, K M</creator><creator>Bánky, Z</creator><creator>Tóth, B E</creator><creator>Nagy, G M</creator><creator>Halász, B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>Dual role of glucocorticoids in suckling-induced prolactin secretion</title><author>Horváth, K M ; Bánky, Z ; Tóth, B E ; Nagy, G M ; Halász, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-868884f02cb87123b2329078bd4281a3da3db1acf82bc8fcb2e2d3a599d58413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adrenalectomy</topic><topic>Animals</topic><topic>Animals, Suckling - physiology</topic><topic>Dexamethasone - pharmacology</topic><topic>Feeding Behavior - physiology</topic><topic>Glucocorticoids - physiology</topic><topic>Prolactin - metabolism</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horváth, K M</creatorcontrib><creatorcontrib>Bánky, Z</creatorcontrib><creatorcontrib>Tóth, B E</creatorcontrib><creatorcontrib>Nagy, G M</creatorcontrib><creatorcontrib>Halász, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horváth, K M</au><au>Bánky, Z</au><au>Tóth, B E</au><au>Nagy, G M</au><au>Halász, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dual role of glucocorticoids in suckling-induced prolactin secretion</atitle><jtitle>Endocrine</jtitle><addtitle>Endocrine</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>15</volume><issue>3</issue><spage>287</spage><epage>290</epage><pages>287-290</pages><issn>1355-008X</issn><issn>0969-711X</issn><eissn>0969-711X</eissn><abstract>The exact contribution of corticosteroids to the control of prolactin secretion in lactating rats is poorly understood. 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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adrenalectomy Animals Animals, Suckling - physiology Dexamethasone - pharmacology Feeding Behavior - physiology Glucocorticoids - physiology Prolactin - metabolism Radioimmunoassay Rats Rats, Sprague-Dawley |
| title | Dual role of glucocorticoids in suckling-induced prolactin secretion |
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