Mitigation of stress-induced suppression of contact hypersensitivity by odorant inhalation
Background Various skin functions are affected by stress. We have previously shown that odorant inhalation can regulate skin immune reactions. Objectives To test the hypothesis that certain odorants can mitigate the effects of stress on skin immune reactions. Methods Contact hypersensitivity (CH) re...
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| Veröffentlicht in: | British journal of dermatology (1951) 2001-11, Vol.145 (5), p.716-719 |
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| creator | Hosoi, J. Tanida, M. Tsuchiya, T. |
| description | Background Various skin functions are affected by stress. We have previously shown that odorant inhalation can regulate skin immune reactions.
Objectives To test the hypothesis that certain odorants can mitigate the effects of stress on skin immune reactions.
Methods Contact hypersensitivity (CH) reactions were elicited in C57BL/6 mice. Mice were subjected to immobilization stress and were exposed to odorants for 2 days. Epidermal sheets were stained for I‐A antigens and analysed by confocal laser scanning microscopy. Serum corticosterone levels were assayed by radioimmunoassay.
Results Exposure of mice to 1,3‐dimethoxy‐5‐methylbenzene (DMMB) had no effect on the intact CH reaction, but it upregulated the reaction suppressed by immobilization stress. Other odorants, including terpinyl acetate and valerian oil, had minor effects on the CH reaction. Suppression of I‐A‐positive cells was prevented by DMMB inhalation. Valerian oil, but not DMMB, downregulated stress‐induced plasma corticosterone levels.
Conclusions Results suggest that odorant inhalation modulates various physiological pathways, some of which result in regulation of skin function. |
| doi_str_mv | 10.1046/j.1365-2133.2001.04409.x |
| format | Article |
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Objectives To test the hypothesis that certain odorants can mitigate the effects of stress on skin immune reactions.
Methods Contact hypersensitivity (CH) reactions were elicited in C57BL/6 mice. Mice were subjected to immobilization stress and were exposed to odorants for 2 days. Epidermal sheets were stained for I‐A antigens and analysed by confocal laser scanning microscopy. Serum corticosterone levels were assayed by radioimmunoassay.
Results Exposure of mice to 1,3‐dimethoxy‐5‐methylbenzene (DMMB) had no effect on the intact CH reaction, but it upregulated the reaction suppressed by immobilization stress. Other odorants, including terpinyl acetate and valerian oil, had minor effects on the CH reaction. Suppression of I‐A‐positive cells was prevented by DMMB inhalation. Valerian oil, but not DMMB, downregulated stress‐induced plasma corticosterone levels.
Conclusions Results suggest that odorant inhalation modulates various physiological pathways, some of which result in regulation of skin function.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1046/j.1365-2133.2001.04409.x</identifier><identifier>PMID: 11736894</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Allergic diseases ; Animals ; Biological and medical sciences ; contact hypersensitivity ; Corticosterone - blood ; Dermatitis, Contact - blood ; Dermatitis, Contact - immunology ; Dermatitis, Contact - prevention & control ; Female ; Immobilization ; Immune Tolerance - drug effects ; Immunopathology ; Langerhans cell ; Langerhans Cells - drug effects ; Langerhans Cells - immunology ; Medical sciences ; Methylene Blue - analogs & derivatives ; Methylene Blue - pharmacology ; Mice ; Mice, Inbred C57BL ; odorant ; Odorants ; Picryl Chloride ; Plant Oils - pharmacology ; Skin allergic diseases. Stinging insect allergies ; stress ; Stress, Physiological - immunology ; Terpenes - pharmacology ; Valerian</subject><ispartof>British journal of dermatology (1951), 2001-11, Vol.145 (5), p.716-719</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Nov 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5269-15ff046d92fb12b16fd56acdeddba7faf70e08ca54f06b1c5328352a6da6737f3</citedby><cites>FETCH-LOGICAL-c5269-15ff046d92fb12b16fd56acdeddba7faf70e08ca54f06b1c5328352a6da6737f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2133.2001.04409.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2133.2001.04409.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14124947$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11736894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hosoi, J.</creatorcontrib><creatorcontrib>Tanida, M.</creatorcontrib><creatorcontrib>Tsuchiya, T.</creatorcontrib><title>Mitigation of stress-induced suppression of contact hypersensitivity by odorant inhalation</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Background Various skin functions are affected by stress. We have previously shown that odorant inhalation can regulate skin immune reactions.
Objectives To test the hypothesis that certain odorants can mitigate the effects of stress on skin immune reactions.
Methods Contact hypersensitivity (CH) reactions were elicited in C57BL/6 mice. Mice were subjected to immobilization stress and were exposed to odorants for 2 days. Epidermal sheets were stained for I‐A antigens and analysed by confocal laser scanning microscopy. Serum corticosterone levels were assayed by radioimmunoassay.
Results Exposure of mice to 1,3‐dimethoxy‐5‐methylbenzene (DMMB) had no effect on the intact CH reaction, but it upregulated the reaction suppressed by immobilization stress. Other odorants, including terpinyl acetate and valerian oil, had minor effects on the CH reaction. Suppression of I‐A‐positive cells was prevented by DMMB inhalation. Valerian oil, but not DMMB, downregulated stress‐induced plasma corticosterone levels.
Conclusions Results suggest that odorant inhalation modulates various physiological pathways, some of which result in regulation of skin function.</description><subject>Allergic diseases</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>contact hypersensitivity</subject><subject>Corticosterone - blood</subject><subject>Dermatitis, Contact - blood</subject><subject>Dermatitis, Contact - immunology</subject><subject>Dermatitis, Contact - prevention & control</subject><subject>Female</subject><subject>Immobilization</subject><subject>Immune Tolerance - drug effects</subject><subject>Immunopathology</subject><subject>Langerhans cell</subject><subject>Langerhans Cells - drug effects</subject><subject>Langerhans Cells - immunology</subject><subject>Medical sciences</subject><subject>Methylene Blue - analogs & derivatives</subject><subject>Methylene Blue - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>odorant</subject><subject>Odorants</subject><subject>Picryl Chloride</subject><subject>Plant Oils - pharmacology</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>stress</subject><subject>Stress, Physiological - immunology</subject><subject>Terpenes - pharmacology</subject><subject>Valerian</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1u1DAUhS0EokPhFVCEBLuE699MFizoQFvQUBaAQGwsxz_UQyYJdgKTt8fpRK3EipUt3-8cXX8IZRgKDEy83BWYCp4TTGlBAHABjEFVHO6h1e3gPloBQJlDJegJehTjLoEUODxEJxiXVKwrtkLfP_jB_1CD79qsc1kcgo0x960ZtTVZHPt-flimumsHpYfseuptiLaNKfvbD1NWT1lnuqDaIfPttWpu-h6jB0410T5ZzlP05fzt581lvv148W7zeptrTkSVY-5c-pOpiKsxqbFwhguljTWmVqVTrgQLa604cyBqrDkla8qJEkaJkpaOnqIXx94-dL9GGwe591HbplGt7cYoS0IZEGAJfPYPuOvG0KbdZJIIfI1ZlaD1EdKhizFYJ_vg9ypMEoOc5cudnB3L2fGcw_JGvjyk6NOlf6z31twFF9sJeL4AKmrVuCRM-3jHMUxYxcrEvTpyf3xjp_9eQJ69fzPfUj4_5n0c7OE2r8JPOSvj8uvVhWSX59tPG_5NXtG_whKwcA</recordid><startdate>200111</startdate><enddate>200111</enddate><creator>Hosoi, J.</creator><creator>Tanida, M.</creator><creator>Tsuchiya, T.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200111</creationdate><title>Mitigation of stress-induced suppression of contact hypersensitivity by odorant inhalation</title><author>Hosoi, J. ; Tanida, M. ; Tsuchiya, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5269-15ff046d92fb12b16fd56acdeddba7faf70e08ca54f06b1c5328352a6da6737f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Allergic diseases</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>contact hypersensitivity</topic><topic>Corticosterone - blood</topic><topic>Dermatitis, Contact - blood</topic><topic>Dermatitis, Contact - immunology</topic><topic>Dermatitis, Contact - prevention & control</topic><topic>Female</topic><topic>Immobilization</topic><topic>Immune Tolerance - drug effects</topic><topic>Immunopathology</topic><topic>Langerhans cell</topic><topic>Langerhans Cells - drug effects</topic><topic>Langerhans Cells - immunology</topic><topic>Medical sciences</topic><topic>Methylene Blue - analogs & derivatives</topic><topic>Methylene Blue - pharmacology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>odorant</topic><topic>Odorants</topic><topic>Picryl Chloride</topic><topic>Plant Oils - pharmacology</topic><topic>Skin allergic diseases. Stinging insect allergies</topic><topic>stress</topic><topic>Stress, Physiological - immunology</topic><topic>Terpenes - pharmacology</topic><topic>Valerian</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hosoi, J.</creatorcontrib><creatorcontrib>Tanida, M.</creatorcontrib><creatorcontrib>Tsuchiya, T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hosoi, J.</au><au>Tanida, M.</au><au>Tsuchiya, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitigation of stress-induced suppression of contact hypersensitivity by odorant inhalation</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2001-11</date><risdate>2001</risdate><volume>145</volume><issue>5</issue><spage>716</spage><epage>719</epage><pages>716-719</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Background Various skin functions are affected by stress. We have previously shown that odorant inhalation can regulate skin immune reactions.
Objectives To test the hypothesis that certain odorants can mitigate the effects of stress on skin immune reactions.
Methods Contact hypersensitivity (CH) reactions were elicited in C57BL/6 mice. Mice were subjected to immobilization stress and were exposed to odorants for 2 days. Epidermal sheets were stained for I‐A antigens and analysed by confocal laser scanning microscopy. Serum corticosterone levels were assayed by radioimmunoassay.
Results Exposure of mice to 1,3‐dimethoxy‐5‐methylbenzene (DMMB) had no effect on the intact CH reaction, but it upregulated the reaction suppressed by immobilization stress. Other odorants, including terpinyl acetate and valerian oil, had minor effects on the CH reaction. Suppression of I‐A‐positive cells was prevented by DMMB inhalation. Valerian oil, but not DMMB, downregulated stress‐induced plasma corticosterone levels.
Conclusions Results suggest that odorant inhalation modulates various physiological pathways, some of which result in regulation of skin function.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11736894</pmid><doi>10.1046/j.1365-2133.2001.04409.x</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Allergic diseases Animals Biological and medical sciences contact hypersensitivity Corticosterone - blood Dermatitis, Contact - blood Dermatitis, Contact - immunology Dermatitis, Contact - prevention & control Female Immobilization Immune Tolerance - drug effects Immunopathology Langerhans cell Langerhans Cells - drug effects Langerhans Cells - immunology Medical sciences Methylene Blue - analogs & derivatives Methylene Blue - pharmacology Mice Mice, Inbred C57BL odorant Odorants Picryl Chloride Plant Oils - pharmacology Skin allergic diseases. Stinging insect allergies stress Stress, Physiological - immunology Terpenes - pharmacology Valerian |
| title | Mitigation of stress-induced suppression of contact hypersensitivity by odorant inhalation |
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