Efficacy of macrolides used in combination with ethambutol, with or without other drugs, against Mycobacterium avium within human macrophages
The activities of clarithromycin or roxithromicin used in combination with other antimicrobial drugs were tested in human macrophages experimentally infected with 23 strains of Mycobacterium avium. Overall, clarithromycin–ethambutol–rifampicin was the most active combination tested. The reduction in...
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| Veröffentlicht in: | International journal of antimicrobial agents 2001-12, Vol.18 (6), p.525-530 |
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| container_title | International journal of antimicrobial agents |
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| creator | Schiavano, Giuditta F Celeste, Angela G Salvaggio, Leonardo Sisti, Maurizio Brandi, Giorgio |
| description | The activities of clarithromycin or roxithromicin used in combination with other antimicrobial drugs were tested in human macrophages experimentally infected with 23 strains of
Mycobacterium avium. Overall, clarithromycin–ethambutol–rifampicin was the most active combination tested. The reduction in intracellular viable bacilli was found to be more than 1 log
10 for 95% and more than 2 logs
10 for 65% of the strains. The second most active combination was roxithromycin–ethambutol–rifampicin, which was found to be bactericidal for about 80% and highly bactericidal for 20% of the strains. Others combinations were only bacteriostatic or weakly bactericidal for many of the strains. The addition of a third drug did not necessarily promote enhanced bacterial killing inside the macrophage. |
| doi_str_mv | 10.1016/S0924-8579(01)00461-7 |
| format | Article |
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Mycobacterium avium. Overall, clarithromycin–ethambutol–rifampicin was the most active combination tested. The reduction in intracellular viable bacilli was found to be more than 1 log
10 for 95% and more than 2 logs
10 for 65% of the strains. The second most active combination was roxithromycin–ethambutol–rifampicin, which was found to be bactericidal for about 80% and highly bactericidal for 20% of the strains. Others combinations were only bacteriostatic or weakly bactericidal for many of the strains. The addition of a third drug did not necessarily promote enhanced bacterial killing inside the macrophage.</description><identifier>ISSN: 0924-8579</identifier><identifier>EISSN: 1872-7913</identifier><identifier>DOI: 10.1016/S0924-8579(01)00461-7</identifier><identifier>PMID: 11738339</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antimicrobial drugs ; Antitubercular Agents - pharmacology ; Biological and medical sciences ; Cells, Cultured ; Clarithromycin - pharmacology ; Drug Therapy, Combination - pharmacology ; Ethambutol - pharmacology ; Humans ; Intracellular killing ; Macrophages ; Macrophages - microbiology ; Medical sciences ; Microbial Sensitivity Tests ; Mycobacterium avium ; Mycobacterium avium - drug effects ; Mycobacterium avium - growth & development ; Pharmacology. Drug treatments ; Rifampin - pharmacology</subject><ispartof>International journal of antimicrobial agents, 2001-12, Vol.18 (6), p.525-530</ispartof><rights>2001 Elsevier Science B.V. and International Society of Chemotherapy</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-fd13cd667700902d1138c5ecb495d676807bdfed0b7730ea41f3bcbdc74cb7b23</citedby><cites>FETCH-LOGICAL-c422t-fd13cd667700902d1138c5ecb495d676807bdfed0b7730ea41f3bcbdc74cb7b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0924857901004617$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14128750$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11738339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schiavano, Giuditta F</creatorcontrib><creatorcontrib>Celeste, Angela G</creatorcontrib><creatorcontrib>Salvaggio, Leonardo</creatorcontrib><creatorcontrib>Sisti, Maurizio</creatorcontrib><creatorcontrib>Brandi, Giorgio</creatorcontrib><title>Efficacy of macrolides used in combination with ethambutol, with or without other drugs, against Mycobacterium avium within human macrophages</title><title>International journal of antimicrobial agents</title><addtitle>Int J Antimicrob Agents</addtitle><description>The activities of clarithromycin or roxithromicin used in combination with other antimicrobial drugs were tested in human macrophages experimentally infected with 23 strains of
Mycobacterium avium. Overall, clarithromycin–ethambutol–rifampicin was the most active combination tested. The reduction in intracellular viable bacilli was found to be more than 1 log
10 for 95% and more than 2 logs
10 for 65% of the strains. The second most active combination was roxithromycin–ethambutol–rifampicin, which was found to be bactericidal for about 80% and highly bactericidal for 20% of the strains. Others combinations were only bacteriostatic or weakly bactericidal for many of the strains. The addition of a third drug did not necessarily promote enhanced bacterial killing inside the macrophage.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimicrobial drugs</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Clarithromycin - pharmacology</subject><subject>Drug Therapy, Combination - pharmacology</subject><subject>Ethambutol - pharmacology</subject><subject>Humans</subject><subject>Intracellular killing</subject><subject>Macrophages</subject><subject>Macrophages - microbiology</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Mycobacterium avium</subject><subject>Mycobacterium avium - drug effects</subject><subject>Mycobacterium avium - growth & development</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antimicrobial drugs</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Clarithromycin - pharmacology</topic><topic>Drug Therapy, Combination - pharmacology</topic><topic>Ethambutol - pharmacology</topic><topic>Humans</topic><topic>Intracellular killing</topic><topic>Macrophages</topic><topic>Macrophages - microbiology</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Mycobacterium avium</topic><topic>Mycobacterium avium - drug effects</topic><topic>Mycobacterium avium - growth & development</topic><topic>Pharmacology. 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10 for 95% and more than 2 logs
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| subjects | Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial drugs Antitubercular Agents - pharmacology Biological and medical sciences Cells, Cultured Clarithromycin - pharmacology Drug Therapy, Combination - pharmacology Ethambutol - pharmacology Humans Intracellular killing Macrophages Macrophages - microbiology Medical sciences Microbial Sensitivity Tests Mycobacterium avium Mycobacterium avium - drug effects Mycobacterium avium - growth & development Pharmacology. Drug treatments Rifampin - pharmacology |
| title | Efficacy of macrolides used in combination with ethambutol, with or without other drugs, against Mycobacterium avium within human macrophages |
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