Influence of Nicotinamide on the Radiosensitivity of Normal and Goitrous Thyroid in the Rat
Radioiodine is used to treat thyroid cancer and hyperthyroidism. In order to reduce radiation hazard to the patient and to people in contact with the patient it would be desirable to obtain the same therapeutic effect with lower activities of the radioisotope. This could be achieved by the simultane...
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| Veröffentlicht in: | Thyroid (New York, N.Y.) N.Y.), 2001-11, Vol.11 (11), p.13-1007 |
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| creator | Agote, M. Viaggi, M. Kreimann, E. Krawiec, L. Dagrosa, M.A. Juvenal, G.J. Pisarev, M.A. |
| description | Radioiodine is used to treat thyroid cancer and hyperthyroidism. In order to reduce radiation hazard to the patient and to people in contact with the patient it would be desirable to obtain the same therapeutic
effect with lower activities of the radioisotope. This could be achieved by the simultaneous administration of a compound that increases tissue radiosensitivity. In this study we analyzed the use of nicotinamide
(NA) as a radiosensitizer to radioiodine, to increase
131
I efficacy. NA administered during 30 days to Wistar rats failed to alter thyroid weight. The influence of NA on radiothyroidectomy induced
by increasing doses of
131
I was examined in otherwise nontreated rats. NA produced a significant increase in the ablation caused by radioiodine. Goiter was then induced by the administration
of methylmercaptoimidazol (MMI) to rats, followed by the treatment with radioiodine with and without simultaneous administration of NA. Thyroid weight per 100 g of body weight ratio was not changed by NA
alone;
131
I administration caused a 25% decrease in goiter size, while
131
I plus NA produced a reduction of the ratio of 46% (
p
< 0.01 vs. NA). No changes were observed in
adenosine diphosphate (ADP)-ribosilation of thyroid nuclear protein in NA-treated rats. Thyroid blood flow (determined by
86
Rb uptake) was increased by 84% by NA. In conclusion, nicotinamide
has a significant radiosensitizing effect to
131
I both in normal and goitrous rats. This action is because of an increase in thyroid blood flow, which probably enhances tissue oxgenation. |
| doi_str_mv | 10.1089/105072501753271671 |
| format | Article |
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effect with lower activities of the radioisotope. This could be achieved by the simultaneous administration of a compound that increases tissue radiosensitivity. In this study we analyzed the use of nicotinamide
(NA) as a radiosensitizer to radioiodine, to increase
131
I efficacy. NA administered during 30 days to Wistar rats failed to alter thyroid weight. The influence of NA on radiothyroidectomy induced
by increasing doses of
131
I was examined in otherwise nontreated rats. NA produced a significant increase in the ablation caused by radioiodine. Goiter was then induced by the administration
of methylmercaptoimidazol (MMI) to rats, followed by the treatment with radioiodine with and without simultaneous administration of NA. Thyroid weight per 100 g of body weight ratio was not changed by NA
alone;
131
I administration caused a 25% decrease in goiter size, while
131
I plus NA produced a reduction of the ratio of 46% (
p
< 0.01 vs. NA). No changes were observed in
adenosine diphosphate (ADP)-ribosilation of thyroid nuclear protein in NA-treated rats. Thyroid blood flow (determined by
86
Rb uptake) was increased by 84% by NA. In conclusion, nicotinamide
has a significant radiosensitizing effect to
131
I both in normal and goitrous rats. This action is because of an increase in thyroid blood flow, which probably enhances tissue oxgenation.</description><identifier>ISSN: 1050-7256</identifier><identifier>EISSN: 1557-9077</identifier><identifier>DOI: 10.1089/105072501753271671</identifier><identifier>PMID: 11762708</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adenosine Diphosphate Ribose - metabolism ; Animals ; Antithyroid Agents - pharmacology ; Cell Nucleus - drug effects ; Female ; Goiter - radiotherapy ; Iodine Radioisotopes - pharmacokinetics ; Laboratory Research Reports ; Methimazole - pharmacology ; Niacinamide - pharmacology ; Radiation Tolerance - drug effects ; Rats ; Rats, Wistar ; Regional Blood Flow - drug effects ; Rubidium Radioisotopes - pharmacokinetics ; Thyroid Gland - blood supply ; Thyroid Gland - drug effects</subject><ispartof>Thyroid (New York, N.Y.), 2001-11, Vol.11 (11), p.13-1007</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-7b31726c34845b4c5a54bc8311e60b457c9f7b13e2781830eb925b492848eb3e3</citedby><cites>FETCH-LOGICAL-c348t-7b31726c34845b4c5a54bc8311e60b457c9f7b13e2781830eb925b492848eb3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.liebertpub.com/doi/epdf/10.1089/105072501753271671$$EPDF$$P50$$Gmaryannliebert$$H</linktopdf><linktohtml>$$Uhttps://www.liebertpub.com/doi/full/10.1089/105072501753271671$$EHTML$$P50$$Gmaryannliebert$$H</linktohtml><link.rule.ids>314,778,782,3031,21710,27911,27912,55278,55290</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11762708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agote, M.</creatorcontrib><creatorcontrib>Viaggi, M.</creatorcontrib><creatorcontrib>Kreimann, E.</creatorcontrib><creatorcontrib>Krawiec, L.</creatorcontrib><creatorcontrib>Dagrosa, M.A.</creatorcontrib><creatorcontrib>Juvenal, G.J.</creatorcontrib><creatorcontrib>Pisarev, M.A.</creatorcontrib><title>Influence of Nicotinamide on the Radiosensitivity of Normal and Goitrous Thyroid in the Rat</title><title>Thyroid (New York, N.Y.)</title><addtitle>Thyroid</addtitle><description>Radioiodine is used to treat thyroid cancer and hyperthyroidism. In order to reduce radiation hazard to the patient and to people in contact with the patient it would be desirable to obtain the same therapeutic
effect with lower activities of the radioisotope. This could be achieved by the simultaneous administration of a compound that increases tissue radiosensitivity. In this study we analyzed the use of nicotinamide
(NA) as a radiosensitizer to radioiodine, to increase
131
I efficacy. NA administered during 30 days to Wistar rats failed to alter thyroid weight. The influence of NA on radiothyroidectomy induced
by increasing doses of
131
I was examined in otherwise nontreated rats. NA produced a significant increase in the ablation caused by radioiodine. Goiter was then induced by the administration
of methylmercaptoimidazol (MMI) to rats, followed by the treatment with radioiodine with and without simultaneous administration of NA. Thyroid weight per 100 g of body weight ratio was not changed by NA
alone;
131
I administration caused a 25% decrease in goiter size, while
131
I plus NA produced a reduction of the ratio of 46% (
p
< 0.01 vs. NA). No changes were observed in
adenosine diphosphate (ADP)-ribosilation of thyroid nuclear protein in NA-treated rats. Thyroid blood flow (determined by
86
Rb uptake) was increased by 84% by NA. In conclusion, nicotinamide
has a significant radiosensitizing effect to
131
I both in normal and goitrous rats. This action is because of an increase in thyroid blood flow, which probably enhances tissue oxgenation.</description><subject>Adenosine Diphosphate Ribose - metabolism</subject><subject>Animals</subject><subject>Antithyroid Agents - pharmacology</subject><subject>Cell Nucleus - drug effects</subject><subject>Female</subject><subject>Goiter - radiotherapy</subject><subject>Iodine Radioisotopes - pharmacokinetics</subject><subject>Laboratory Research Reports</subject><subject>Methimazole - pharmacology</subject><subject>Niacinamide - pharmacology</subject><subject>Radiation Tolerance - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regional Blood Flow - drug effects</subject><subject>Rubidium Radioisotopes - pharmacokinetics</subject><subject>Thyroid Gland - blood supply</subject><subject>Thyroid Gland - drug effects</subject><issn>1050-7256</issn><issn>1557-9077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtLxDAUhYMovv-AC-nKXTWPpjddivgCUZBx5aIk7S0TaRNNMsL8ezPOiAs3ru49l-8cLoeQE0bPGVXNBaOSApeUgRQcWA1si-wzKaFsKMB23jNQZqLeIwcxvlHKagVil-wxBjUHqvbJ670bxgW6Dgs_FI-288k6Pdk-a1ekORbPurc-oos22U-blt-cD5MeC-364tbbFPwiFrP5MnjbF_bHlo7IzqDHiMebeUhebq5nV3flw9Pt_dXlQ9mJSqUSjGDA65WopKk6qWVlOiUYw5qaSkLXDGCYQA6KKUHRNDxzDVeVQiNQHJKzde578B8LjKmdbOxwHLXD_FkLXAgFVZVBvga74GMMOLTvwU46LFtG21Wl7d9Ks-l0k74wE_a_lk2HGVBrYHXWzo0WDYb0n-wvncOBaQ</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Agote, M.</creator><creator>Viaggi, M.</creator><creator>Kreimann, E.</creator><creator>Krawiec, L.</creator><creator>Dagrosa, M.A.</creator><creator>Juvenal, G.J.</creator><creator>Pisarev, M.A.</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Influence of Nicotinamide on the Radiosensitivity of Normal and Goitrous Thyroid in the Rat</title><author>Agote, M. ; Viaggi, M. ; Kreimann, E. ; Krawiec, L. ; Dagrosa, M.A. ; Juvenal, G.J. ; Pisarev, M.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-7b31726c34845b4c5a54bc8311e60b457c9f7b13e2781830eb925b492848eb3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adenosine Diphosphate Ribose - metabolism</topic><topic>Animals</topic><topic>Antithyroid Agents - pharmacology</topic><topic>Cell Nucleus - drug effects</topic><topic>Female</topic><topic>Goiter - radiotherapy</topic><topic>Iodine Radioisotopes - pharmacokinetics</topic><topic>Laboratory Research Reports</topic><topic>Methimazole - pharmacology</topic><topic>Niacinamide - pharmacology</topic><topic>Radiation Tolerance - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Regional Blood Flow - drug effects</topic><topic>Rubidium Radioisotopes - pharmacokinetics</topic><topic>Thyroid Gland - blood supply</topic><topic>Thyroid Gland - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agote, M.</creatorcontrib><creatorcontrib>Viaggi, M.</creatorcontrib><creatorcontrib>Kreimann, E.</creatorcontrib><creatorcontrib>Krawiec, L.</creatorcontrib><creatorcontrib>Dagrosa, M.A.</creatorcontrib><creatorcontrib>Juvenal, G.J.</creatorcontrib><creatorcontrib>Pisarev, M.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thyroid (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agote, M.</au><au>Viaggi, M.</au><au>Kreimann, E.</au><au>Krawiec, L.</au><au>Dagrosa, M.A.</au><au>Juvenal, G.J.</au><au>Pisarev, M.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Nicotinamide on the Radiosensitivity of Normal and Goitrous Thyroid in the Rat</atitle><jtitle>Thyroid (New York, N.Y.)</jtitle><addtitle>Thyroid</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>11</volume><issue>11</issue><spage>13</spage><epage>1007</epage><pages>13-1007</pages><issn>1050-7256</issn><eissn>1557-9077</eissn><abstract>Radioiodine is used to treat thyroid cancer and hyperthyroidism. In order to reduce radiation hazard to the patient and to people in contact with the patient it would be desirable to obtain the same therapeutic
effect with lower activities of the radioisotope. This could be achieved by the simultaneous administration of a compound that increases tissue radiosensitivity. In this study we analyzed the use of nicotinamide
(NA) as a radiosensitizer to radioiodine, to increase
131
I efficacy. NA administered during 30 days to Wistar rats failed to alter thyroid weight. The influence of NA on radiothyroidectomy induced
by increasing doses of
131
I was examined in otherwise nontreated rats. NA produced a significant increase in the ablation caused by radioiodine. Goiter was then induced by the administration
of methylmercaptoimidazol (MMI) to rats, followed by the treatment with radioiodine with and without simultaneous administration of NA. Thyroid weight per 100 g of body weight ratio was not changed by NA
alone;
131
I administration caused a 25% decrease in goiter size, while
131
I plus NA produced a reduction of the ratio of 46% (
p
< 0.01 vs. NA). No changes were observed in
adenosine diphosphate (ADP)-ribosilation of thyroid nuclear protein in NA-treated rats. Thyroid blood flow (determined by
86
Rb uptake) was increased by 84% by NA. In conclusion, nicotinamide
has a significant radiosensitizing effect to
131
I both in normal and goitrous rats. This action is because of an increase in thyroid blood flow, which probably enhances tissue oxgenation.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>11762708</pmid><doi>10.1089/105072501753271671</doi><tpages>995</tpages></addata></record> |
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| language | eng |
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| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Adenosine Diphosphate Ribose - metabolism Animals Antithyroid Agents - pharmacology Cell Nucleus - drug effects Female Goiter - radiotherapy Iodine Radioisotopes - pharmacokinetics Laboratory Research Reports Methimazole - pharmacology Niacinamide - pharmacology Radiation Tolerance - drug effects Rats Rats, Wistar Regional Blood Flow - drug effects Rubidium Radioisotopes - pharmacokinetics Thyroid Gland - blood supply Thyroid Gland - drug effects |
| title | Influence of Nicotinamide on the Radiosensitivity of Normal and Goitrous Thyroid in the Rat |
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