Serotonergic mechanisms of the lateral parabrachial nucleus on DOCA-induced sodium intake
It has been shown that the serotonergic mechanisms of the lateral parabrachial nucleus (LPBN) inhibit NaCl intake in different models of angiotensin II (ANG II)-dependent NaCl intake in rats. However, there is no information about the involvement of LPBN serotonergic mechanisms on NaCl intake in a m...
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| description | It has been shown that the serotonergic mechanisms of the lateral parabrachial nucleus (LPBN) inhibit NaCl intake in different models of angiotensin II (ANG II)-dependent NaCl intake in rats. However, there is no information about the involvement of LPBN serotonergic mechanisms on NaCl intake in a model of NaCl intake not dependent on ANG II like deoxycorticosterone (DOCA)-induced NaCl intake. Therefore, in this study we investigated the effects of bilateral injections of serotonergic agonist and antagonist into the LPBN on DOCA-induced 1.8% NaCl intake in rats. Male Holtzman rats were treated with s.c. DOCA (10 mg/rat each every 3 days). After a period of training, in which the rats had access to 1.8% NaCl during 2 h for several days, the rats were implanted with stainless steel cannulas bilaterally into the LPBN. Bilateral injections of the serotonergic receptor antagonist methysergide (4 μg/0.2 μl each site) in the LPBN increased 1.8% NaCl intake (32.2±3.9 versus vehicle: 15.0±1.6 ml/2 h,
n=10) and water intake (12.5±3.5 versus vehicle: 3.2±1.0 ml/2 h). Injections of the serotonergic 5HT
2A/2C receptor agonist DOI (5 μg/0,2 μl each site) in the LPBN reduced 1.8% NaCl intake (6.8±1.7 versus saline: 12.4±1.9 ml/2 h,
n=10) and water intake (2.2±0.8 versus saline: 4.4±1.0 ml/2 h). Besides the previously demonstrated importance for the control of ANG II-dependent water and NaCl intake, the data show that the serotonergic inhibitory mechanisms of the LPBN are also involved in the control of DOCA-induced NaCl intake. |
| doi_str_mv | 10.1016/S0006-8993(00)02784-0 |
| format | Article |
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n=10) and water intake (12.5±3.5 versus vehicle: 3.2±1.0 ml/2 h). Injections of the serotonergic 5HT
2A/2C receptor agonist DOI (5 μg/0,2 μl each site) in the LPBN reduced 1.8% NaCl intake (6.8±1.7 versus saline: 12.4±1.9 ml/2 h,
n=10) and water intake (2.2±0.8 versus saline: 4.4±1.0 ml/2 h). Besides the previously demonstrated importance for the control of ANG II-dependent water and NaCl intake, the data show that the serotonergic inhibitory mechanisms of the LPBN are also involved in the control of DOCA-induced NaCl intake.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(00)02784-0</identifier><identifier>PMID: 11032997</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>5HT ; Amphetamines - administration & dosage ; Amphetamines - pharmacology ; Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Cerebellar Nuclei - drug effects ; Cerebellar Nuclei - physiology ; Deoxycorticosterone ; Desoxycorticosterone - administration & dosage ; Desoxycorticosterone - pharmacology ; Drinking Behavior - drug effects ; Drinking Behavior - physiology ; Feeding Behavior - drug effects ; Feeding Behavior - physiology ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Heart Rate - drug effects ; LPBN ; Male ; Methysergide - administration & dosage ; Methysergide - pharmacology ; Microinjections ; NaCl intake ; parabrachial nucleus (lateral) ; Rats ; Rats, Sprague-Dawley ; Serotonin - physiology ; Serotonin Receptor Agonists - pharmacology ; Sodium, Dietary ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Water intake</subject><ispartof>Brain research, 2000-10, Vol.880 (1), p.131-138</ispartof><rights>2000 Elsevier Science B.V.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-6013f353d69e8601cfbbbaa0a6c5f0e59166b841f66ee2b48b599cd043543f63</citedby><cites>FETCH-LOGICAL-c420t-6013f353d69e8601cfbbbaa0a6c5f0e59166b841f66ee2b48b599cd043543f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899300027840$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=798080$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11032997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Gobbi, Juliana Irani Fratucci</creatorcontrib><creatorcontrib>De Luca, Laurival Antonio</creatorcontrib><creatorcontrib>Menani, José Vanderlei</creatorcontrib><title>Serotonergic mechanisms of the lateral parabrachial nucleus on DOCA-induced sodium intake</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>It has been shown that the serotonergic mechanisms of the lateral parabrachial nucleus (LPBN) inhibit NaCl intake in different models of angiotensin II (ANG II)-dependent NaCl intake in rats. However, there is no information about the involvement of LPBN serotonergic mechanisms on NaCl intake in a model of NaCl intake not dependent on ANG II like deoxycorticosterone (DOCA)-induced NaCl intake. Therefore, in this study we investigated the effects of bilateral injections of serotonergic agonist and antagonist into the LPBN on DOCA-induced 1.8% NaCl intake in rats. Male Holtzman rats were treated with s.c. DOCA (10 mg/rat each every 3 days). After a period of training, in which the rats had access to 1.8% NaCl during 2 h for several days, the rats were implanted with stainless steel cannulas bilaterally into the LPBN. Bilateral injections of the serotonergic receptor antagonist methysergide (4 μg/0.2 μl each site) in the LPBN increased 1.8% NaCl intake (32.2±3.9 versus vehicle: 15.0±1.6 ml/2 h,
n=10) and water intake (12.5±3.5 versus vehicle: 3.2±1.0 ml/2 h). Injections of the serotonergic 5HT
2A/2C receptor agonist DOI (5 μg/0,2 μl each site) in the LPBN reduced 1.8% NaCl intake (6.8±1.7 versus saline: 12.4±1.9 ml/2 h,
n=10) and water intake (2.2±0.8 versus saline: 4.4±1.0 ml/2 h). Besides the previously demonstrated importance for the control of ANG II-dependent water and NaCl intake, the data show that the serotonergic inhibitory mechanisms of the LPBN are also involved in the control of DOCA-induced NaCl intake.</description><subject>5HT</subject><subject>Amphetamines - administration & dosage</subject><subject>Amphetamines - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cerebellar Nuclei - drug effects</subject><subject>Cerebellar Nuclei - physiology</subject><subject>Deoxycorticosterone</subject><subject>Desoxycorticosterone - administration & dosage</subject><subject>Desoxycorticosterone - pharmacology</subject><subject>Drinking Behavior - drug effects</subject><subject>Drinking Behavior - physiology</subject><subject>Feeding Behavior - drug effects</subject><subject>Feeding Behavior - physiology</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - drug effects</subject><subject>LPBN</subject><subject>Male</subject><subject>Methysergide - administration & dosage</subject><subject>Methysergide - pharmacology</subject><subject>Microinjections</subject><subject>NaCl intake</subject><subject>parabrachial nucleus (lateral)</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Serotonin - physiology</subject><subject>Serotonin Receptor Agonists - pharmacology</subject><subject>Sodium, Dietary</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Water intake</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFO3DAQhi1EBQvtI7SKhIToIXRsJ459QquFAhISB7j0ZDnOuOs2cbZ2Uom3r5dd0SOn0S99_8zoI-QzhUsKVHx7AgBRSqX4BcBXYI2sSjggCyobVgpWwSFZvCHH5CSlXzlyruCIHFMKnCnVLMiPJ4zjNAaMP70tBrRrE3waUjG6Ylpj0ZsJo-mLjYmmjcaufQ5htj3OmQnF9eNqWfrQzRa7Io2dn4fCh8n8xo_kgzN9wk_7eUqev988r-7Kh8fb-9XyobQVg6kUQLnjNe-EQpmDdW3bGgNG2NoB1ooK0cqKOiEQWVvJtlbKdlDxuuJO8FNyvlu7ieOfGdOkB58s9r0JOM5JN4xz2VD5LkibhilRswzWO9DGMaWITm-iH0x80RT01r1-da-3YjWAfnWvIfe-7A_M7YDd_9ZedgbO9oBJ1vQummB9euMaJUFu11ztKMzS_nqMOlmPIfv1Ee2ku9G_88g_xg-f4w</recordid><startdate>20001013</startdate><enddate>20001013</enddate><creator>De Gobbi, Juliana Irani Fratucci</creator><creator>De Luca, Laurival Antonio</creator><creator>Menani, José Vanderlei</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20001013</creationdate><title>Serotonergic mechanisms of the lateral parabrachial nucleus on DOCA-induced sodium intake</title><author>De Gobbi, Juliana Irani Fratucci ; De Luca, Laurival Antonio ; Menani, José Vanderlei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-6013f353d69e8601cfbbbaa0a6c5f0e59166b841f66ee2b48b599cd043543f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>5HT</topic><topic>Amphetamines - administration & dosage</topic><topic>Amphetamines - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cerebellar Nuclei - drug effects</topic><topic>Cerebellar Nuclei - physiology</topic><topic>Deoxycorticosterone</topic><topic>Desoxycorticosterone - administration & dosage</topic><topic>Desoxycorticosterone - pharmacology</topic><topic>Drinking Behavior - drug effects</topic><topic>Drinking Behavior - physiology</topic><topic>Feeding Behavior - drug effects</topic><topic>Feeding Behavior - physiology</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate - drug effects</topic><topic>LPBN</topic><topic>Male</topic><topic>Methysergide - administration & dosage</topic><topic>Methysergide - pharmacology</topic><topic>Microinjections</topic><topic>NaCl intake</topic><topic>parabrachial nucleus (lateral)</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Serotonin - physiology</topic><topic>Serotonin Receptor Agonists - pharmacology</topic><topic>Sodium, Dietary</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Water intake</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Gobbi, Juliana Irani Fratucci</creatorcontrib><creatorcontrib>De Luca, Laurival Antonio</creatorcontrib><creatorcontrib>Menani, José Vanderlei</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Gobbi, Juliana Irani Fratucci</au><au>De Luca, Laurival Antonio</au><au>Menani, José Vanderlei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotonergic mechanisms of the lateral parabrachial nucleus on DOCA-induced sodium intake</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2000-10-13</date><risdate>2000</risdate><volume>880</volume><issue>1</issue><spage>131</spage><epage>138</epage><pages>131-138</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>It has been shown that the serotonergic mechanisms of the lateral parabrachial nucleus (LPBN) inhibit NaCl intake in different models of angiotensin II (ANG II)-dependent NaCl intake in rats. However, there is no information about the involvement of LPBN serotonergic mechanisms on NaCl intake in a model of NaCl intake not dependent on ANG II like deoxycorticosterone (DOCA)-induced NaCl intake. Therefore, in this study we investigated the effects of bilateral injections of serotonergic agonist and antagonist into the LPBN on DOCA-induced 1.8% NaCl intake in rats. Male Holtzman rats were treated with s.c. DOCA (10 mg/rat each every 3 days). After a period of training, in which the rats had access to 1.8% NaCl during 2 h for several days, the rats were implanted with stainless steel cannulas bilaterally into the LPBN. Bilateral injections of the serotonergic receptor antagonist methysergide (4 μg/0.2 μl each site) in the LPBN increased 1.8% NaCl intake (32.2±3.9 versus vehicle: 15.0±1.6 ml/2 h,
n=10) and water intake (12.5±3.5 versus vehicle: 3.2±1.0 ml/2 h). Injections of the serotonergic 5HT
2A/2C receptor agonist DOI (5 μg/0,2 μl each site) in the LPBN reduced 1.8% NaCl intake (6.8±1.7 versus saline: 12.4±1.9 ml/2 h,
n=10) and water intake (2.2±0.8 versus saline: 4.4±1.0 ml/2 h). Besides the previously demonstrated importance for the control of ANG II-dependent water and NaCl intake, the data show that the serotonergic inhibitory mechanisms of the LPBN are also involved in the control of DOCA-induced NaCl intake.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>11032997</pmid><doi>10.1016/S0006-8993(00)02784-0</doi><tpages>8</tpages></addata></record> |
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| subjects | 5HT Amphetamines - administration & dosage Amphetamines - pharmacology Animals Biological and medical sciences Blood Pressure - drug effects Cerebellar Nuclei - drug effects Cerebellar Nuclei - physiology Deoxycorticosterone Desoxycorticosterone - administration & dosage Desoxycorticosterone - pharmacology Drinking Behavior - drug effects Drinking Behavior - physiology Feeding Behavior - drug effects Feeding Behavior - physiology Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Heart Rate - drug effects LPBN Male Methysergide - administration & dosage Methysergide - pharmacology Microinjections NaCl intake parabrachial nucleus (lateral) Rats Rats, Sprague-Dawley Serotonin - physiology Serotonin Receptor Agonists - pharmacology Sodium, Dietary Vertebrates: anatomy and physiology, studies on body, several organs or systems Water intake |
| title | Serotonergic mechanisms of the lateral parabrachial nucleus on DOCA-induced sodium intake |
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