Recombinant Annexin II Modulates Impaired Fibrinolytic Activity In Vitro and in Rat Carotid Artery

Fibrinolytic activity has been reported to be decreased in atherosclerosis. Recently, annexin II was identified as a coreceptor on endothelial cells for plasminogen and tissue plasminogen activator. In this study, we examined whether recombinant annexin II (rAN II) protein can modulate fibrinolytic...

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Veröffentlicht in:	Circulation research 2001-12, Vol.89 (12), p.1240-1245
Hauptverfasser:	Ishii, Hideto, Yoshida, Masayuki, Hiraoka, Megumi, Hajjar, Katherine A, Tanaka, Akira, Yasukochi, Yukio, Numano, Fujio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A2 - genetics Annexin A2 - metabolism Annexin A2 - pharmacology Biological and medical sciences Bleeding Time Blood Coagulation - drug effects Blotting, Western Cardiovascular system Carotid Arteries - drug effects Carotid Arteries - metabolism Carotid Arteries - pathology Carotid Artery Thrombosis - pathology Carotid Artery Thrombosis - prevention & control Cells, Cultured Disease Models, Animal Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Fibrinolysin - metabolism Fibrinolysis - drug effects Homocysteine - pharmacology Humans Immunohistochemistry In Vitro Techniques Male Medical sciences Miscellaneous Pharmacology. Drug treatments Plasminogen Activator Inhibitor 1 - pharmacology Rats Rats, Sprague-Dawley Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - pharmacology
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