Genome-wide linkage analysis of systolic and diastolic blood pressure : The Québec Family Study

Genome-wide linkage analysis of systolic and diastolic blood pressure : The Québec Family Study

Blood pressure (BP), an important risk factor for coronary heart disease, is a complex trait with multiple genetic etiologies. While some loci affecting BP variation are known (eg, angiotensinogen), there are likely to be novel signals that can be detected with a genome scan approach. A genome-wide...

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Veröffentlicht in:Circulation (New York, N.Y.) N.Y.), 2000-10, Vol.102 (16), p.1956-1963
Hauptverfasser: RICE, Treva, RANKINEN, Tuomo, PROVINCE, Michael A, CHAGNON, Yvon C, PERUSSE, Louis, BORECKI, Ingrid B, BOUCHARD, Claude, RAO, D. C
Format: Artikel
Sprache:eng
Schlagworte:
Age Distribution
Aged
Biological and medical sciences
Blood Pressure - genetics
Body Mass Index
Cardiology. Vascular system
Chromosome Mapping
Coronary heart disease
Diastole - genetics
Female
Genetic Linkage
Genetic Variation
Genome, Human
Heart
Humans
Hypertension - epidemiology
Hypertension - genetics
Lod Score
Male
Medical sciences
Microsatellite Repeats
Middle Aged
Obesity - epidemiology
Obesity - genetics
Physical Chromosome Mapping
Polymorphism, Restriction Fragment Length
Quantitative Trait, Heritable
Quebec - epidemiology
Regression Analysis
Sex Distribution
Systole - genetics
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Beschreibung
Zusammenfassung:Blood pressure (BP), an important risk factor for coronary heart disease, is a complex trait with multiple genetic etiologies. While some loci affecting BP variation are known (eg, angiotensinogen), there are likely to be novel signals that can be detected with a genome scan approach. A genome-wide scan was performed in 125 random and 81 obese families participating in the Québec Family Study. A multipoint variance-components linkage analysis of 420 markers (353 microsatellites and 67 restriction fragment length polymorphisms) revealed several signals (P:
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.102.16.1956