Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia

We have genotyped over 550 cases of acute leukaemia and 950 matched controls from a population-based case-control study, to investigate the impact cytochrome P450s 2D6, 2C19 and 1A1 have on susceptibility to adult acute leukaemia. Analysis included potential associations between polymorphic status a...

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Veröffentlicht in:	Pharmacogenetics (London) 2000-10, Vol.10 (7), p.605-615
Hauptverfasser:	RODDAM, P. L, ROLLINSON, S, KANE, E, ROMAN, E, MOORMAN, A, CARTWRIGHT, R, MORGAN, G. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adolescent Adult Aged Aryl Hydrocarbon Hydroxylases Base Sequence Biological and medical sciences Case-Control Studies Classical genetics, quantitative genetics, hybrids Cytochrome P-450 CYP2C19 Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism DNA Primers Fundamental and applied biological sciences. Psychology General pharmacology Genetics of eukaryotes. Biological and molecular evolution Human Humans Leukemia, Myeloid - enzymology Medical sciences Middle Aged Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Polymorphism, Genetic Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology Risk Factors
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