Enhanced Na+ Channel Intermediate Inactivation in Brugada Syndrome

Brugada syndrome is an inherited cardiac disease that causes sudden death related to idiopathic ventricular fibrillation in a structurally normal heart. The disease is characterized by ST-segment elevation in the right precordial ECG leads and is frequently accompanied by an apparent right bundle-br...

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Veröffentlicht in:	Circulation research 2000-10, Vol.87 (8), p.e37-e43
Hauptverfasser:	Wang, Dao W, Makita, Naomasa, Kitabatake, Akira, Balser, Jeffrey R, George, Alfred L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Arrhythmias, Cardiac - complications Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - metabolism Bundle-Branch Block - etiology Cell Line Death, Sudden, Cardiac - etiology Genes, Dominant Humans Ion Channel Gating - genetics Kidney - cytology Kidney - metabolism Long QT Syndrome - genetics Long QT Syndrome - metabolism Mutation, Missense NAV1.5 Voltage-Gated Sodium Channel Patch-Clamp Techniques Reaction Time - genetics Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Sodium - metabolism Sodium Channels - genetics Sodium Channels - metabolism Syndrome Temperature Transfection Ventricular Fibrillation - complications Ventricular Fibrillation - genetics Ventricular Fibrillation - metabolism
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