Pulsed-Alkylation Mass Spectrometry for the Study of Protein Folding and Dynamics:  Development and Application to the Study of a Folding/Unfolding Intermediate of Bacterial Luciferase

A new method employing the classical techniques of chemical modification of proteins and the new technology of mass spectrometry, known as pulsed-alkylation mass spectrometry (PA/MS), has been developed to probe the dynamic structure of folding intermediates and folded complexes of proteins under a...

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