Quality of Life in Geriatric Depression: A Comparison of Remitters, Partial Responders, and Nonresponders
The authors examined patterns of improvement in quality of life (QOL) in elderly patients with recurrent major depression (MDD) after acute treatment. One hundred elderly (age 60–88 years) patients with recurrent MDD were randomized to receive either bupropion sustained-release (100 mg–300 mg/day) o...
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| Veröffentlicht in: | The American journal of geriatric psychiatry 2001, Vol.9 (4), p.423-428 |
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| container_title | The American journal of geriatric psychiatry |
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| creator | Doraiswamy, P. Murali Khan, Zeba M. Donahue, Rafe M.J. Richard, Nathalie E. |
| description | The authors examined patterns of improvement in quality of life (QOL) in elderly patients with recurrent major depression (MDD) after acute treatment. One hundred elderly (age 60–88 years) patients with recurrent MDD were randomized to receive either bupropion sustained-release (100 mg–300 mg/day) or paroxetine (10 mg–40 mg/day) for 6 weeks. Treatment with both paroxetine and bupropion was associated with improvements in QOL. Lower perceived Physical- and Social-Functioning QOL ratings at baseline were associated with lower treatment response. Improvement in depression symptom ratings correlated significantly with improvement in QOL on many domains, but accounted for less than one-quarter of the total variance. Remitters showed significantly (P |
| doi_str_mv | 10.1097/00019442-200111000-00011 |
| format | Article |
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Murali ; Khan, Zeba M. ; Donahue, Rafe M.J. ; Richard, Nathalie E.</creator><creatorcontrib>Doraiswamy, P. Murali ; Khan, Zeba M. ; Donahue, Rafe M.J. ; Richard, Nathalie E.</creatorcontrib><description>The authors examined patterns of improvement in quality of life (QOL) in elderly patients with recurrent major depression (MDD) after acute treatment. One hundred elderly (age 60–88 years) patients with recurrent MDD were randomized to receive either bupropion sustained-release (100 mg–300 mg/day) or paroxetine (10 mg–40 mg/day) for 6 weeks. Treatment with both paroxetine and bupropion was associated with improvements in QOL. Lower perceived Physical- and Social-Functioning QOL ratings at baseline were associated with lower treatment response. Improvement in depression symptom ratings correlated significantly with improvement in QOL on many domains, but accounted for less than one-quarter of the total variance. Remitters showed significantly (P<0.001) greater improvement than both Partial Responders and Nonresponders on various measures. Findings support the importance of treating elderly depressed patients to full remission to maximize impact on both emotional and physical QOL domains.</description><identifier>ISSN: 1064-7481</identifier><identifier>EISSN: 1545-7214</identifier><identifier>DOI: 10.1097/00019442-200111000-00011</identifier><identifier>PMID: 11739069</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aged ; Antidepressive Agents, Second-Generation - administration & dosage ; Antidepressive Agents, Second-Generation - therapeutic use ; Bupropion - administration & dosage ; Bupropion - therapeutic use ; Delayed-Action Preparations ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - psychology ; Depressive Disorder, Major - therapy ; Female ; Humans ; Male ; Middle Aged ; Quality of Life ; Remission Induction ; Serotonin Uptake Inhibitors - administration & dosage ; Serotonin Uptake Inhibitors - therapeutic use ; Severity of Illness Index</subject><ispartof>The American journal of geriatric psychiatry, 2001, Vol.9 (4), p.423-428</ispartof><rights>2001 American Association for Geriatric Psychiatry</rights><rights>Copyright American Psychiatric Press, Inc. 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Improvement in depression symptom ratings correlated significantly with improvement in QOL on many domains, but accounted for less than one-quarter of the total variance. Remitters showed significantly (P<0.001) greater improvement than both Partial Responders and Nonresponders on various measures. 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| ispartof | The American journal of geriatric psychiatry, 2001, Vol.9 (4), p.423-428 |
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| subjects | Aged Antidepressive Agents, Second-Generation - administration & dosage Antidepressive Agents, Second-Generation - therapeutic use Bupropion - administration & dosage Bupropion - therapeutic use Delayed-Action Preparations Depressive Disorder, Major - diagnosis Depressive Disorder, Major - psychology Depressive Disorder, Major - therapy Female Humans Male Middle Aged Quality of Life Remission Induction Serotonin Uptake Inhibitors - administration & dosage Serotonin Uptake Inhibitors - therapeutic use Severity of Illness Index |
| title | Quality of Life in Geriatric Depression: A Comparison of Remitters, Partial Responders, and Nonresponders |
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