Tk, a new colon tumor-associated antigen resulting from altered O-glycosylation

Erythrocyte polyagglutination antigens T and Tn are truncated O-glycan chains that are also carcinoma-associated antigens. We investigated whether Tk polyagglutination antigen could similarly be a carcinoma-associated marker and a target of immunotherapy. Monoclonal antibody LM389 was raised against...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-10, Vol.60 (19), p.5499-5507
Hauptverfasser:	Meichenin, M, Rocher, J, Galanina, O, Bovin, N, Nifantev, N, Sherman, A, Cassagnau, E, Heymann, M F, Bara, J, Fraser, R H, Le Pendu, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - immunology Adenocarcinoma - metabolism Adenocarcinoma - prevention & control Animals Antibodies, Monoclonal - immunology Antibody Specificity Antigens, Tumor-Associated, Carbohydrate - biosynthesis Antigens, Tumor-Associated, Carbohydrate - immunology Antigens, Tumor-Associated, Carbohydrate - metabolism beta-Galactosidase - immunology beta-Galactosidase - pharmacology Carbohydrate Sequence Colorectal Neoplasms - immunology Colorectal Neoplasms - metabolism Colorectal Neoplasms - prevention & control Epitopes - immunology Erythrocyte Aggregation - immunology Erythrocytes - immunology Glycoside Hydrolases Glycosylation Hemagglutination - immunology Humans Immunization, Passive Immunohistochemistry Mice Mice, Inbred BALB C Molecular Sequence Data Polysaccharides - immunology Rats Rats, Inbred Strains Tumor Cells, Cultured
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