Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP

A recently identified membrane-type 6 matrix metalloproteinase (MT6-MMP) has a hydrophobic stretch of 24 amino acids at the C-terminus. This hydrophobicity pattern is similar to glycosyl-phosphatidyl inositol (GPI)-anchored MMP, MT4-MMP, and other GPI-anchored proteins. Thus, we tested the possibili...

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Veröffentlicht in:	FEBS letters 2000-09, Vol.480 (2), p.142-146
Hauptverfasser:	Kojima, Shin-ichi, Itoh, Yoshifumi, Matsumoto, Shun-ichiro, Masuho, Yasuhiko, Seiki, Motoharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals CHO Cells COS Cells Cricetinae ECM, extracellular matrix Enzyme Activation Enzyme Precursors - metabolism Glycosyl-phosphatidyl inositol anchor Glycosylphosphatidylinositols - metabolism GPI, glycosyl-phosphatidyl inositol GPI-Linked Proteins Humans Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinases - metabolism Matrix Metalloproteinases, Membrane-Associated Membrane-type 4 matrix metalloproteinase Membrane-type 6 matrix metalloproteinase Mice MMP, matrix metalloproteinase Molecular Sequence Data MT-MMP, membrane-type matrix metalloproteinase PI-PLC, phosphatidyl inositol-specific phospholipase C TIMP, tissue inhibitor of metalloproteinase
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