Toxoplasma gondii secretes a calcium-independent phospholipase A(2)

Phospholipases A(2) (PLA(2)) play an important role in Toxoplasma gondii host cell penetration. They are also key enzymes in the host cell response to the parasite invasion. PLA(2) hydrolyse cellular phospholipids, releasing multiple inflammatory lipidic mediators. We have investigated the biochemic...

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Veröffentlicht in:	International journal for parasitology 2000-10, Vol.30 (11), p.1137-1142
Hauptverfasser:	Cassaing, S, Fauvel, J, Bessières, M H, Guy, S, Séguéla, J P, Chap, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Chloride - chemistry Chromatography, Thin Layer Deoxyribonuclease BamHI - chemistry DNA Primers - chemistry DNA, Protozoan - chemistry DNA, Protozoan - isolation & purification Electrophoresis, Agar Gel Female Fluorometry Hydrogen-Ion Concentration Macrophages, Peritoneal - chemistry Macrophages, Peritoneal - parasitology Mice Mice, Inbred BALB C Mice, Inbred C57BL Phospholipases A - analysis Phospholipases A - antagonists & inhibitors Phospholipases A - chemistry Polymerase Chain Reaction Toxoplasma - enzymology Toxoplasmosis, Animal - enzymology Toxoplasmosis, Animal - parasitology
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