Restriction fragment length polymorphism (RFLP) in exon 2 of the BoLA-DRB3 gene in South American cattle
The Bola-DRB3 gene participates in the development of the immune response and is highly polymorphic. For these reasons, it has been a candidate gene in studies of the genetic basis of disease resistance and in population genetic analysis. South American native cattle breeds have been widely replaced...
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| Veröffentlicht in: | Biochemical genetics 2001-10, Vol.39 (9-10), p.311-329 |
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| creator | Miretti, M M Ferro, J A Lara, M A Contel, E P |
| description | The Bola-DRB3 gene participates in the development of the immune response and is highly polymorphic. For these reasons, it has been a candidate gene in studies of the genetic basis of disease resistance and in population genetic analysis. South American native cattle breeds have been widely replaced by improved exotic breeds leading to a loss of genetic resources. In particular, South American native breeds have high levels of fertility and disease resistance. This work describes genetic variability in the BoLA-DRB3 gene in native (Caracu, Pantaneiro, Argentinean Creole) and exotic (Holstein, Jersey, Nelore, Gir) cattle breeds in Brazil and Argentina. PCR-RFLP alleles were identified by combining the restriction patterns for the BoLA-DRB3.2 locus obtained with RsaI, BstY and HaeIII restriction enzymes. Allelic frequencies and deviations from the Hardy-Weinberg equilibrium were also calculated. Analysis of the 24 BoLA-DRB3 PCR-RFLP alleles identified showed differences in the allele distributions among breeds. |
| doi_str_mv | 10.1023/a:1012204829894 |
| format | Article |
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For these reasons, it has been a candidate gene in studies of the genetic basis of disease resistance and in population genetic analysis. South American native cattle breeds have been widely replaced by improved exotic breeds leading to a loss of genetic resources. In particular, South American native breeds have high levels of fertility and disease resistance. This work describes genetic variability in the BoLA-DRB3 gene in native (Caracu, Pantaneiro, Argentinean Creole) and exotic (Holstein, Jersey, Nelore, Gir) cattle breeds in Brazil and Argentina. PCR-RFLP alleles were identified by combining the restriction patterns for the BoLA-DRB3.2 locus obtained with RsaI, BstY and HaeIII restriction enzymes. Allelic frequencies and deviations from the Hardy-Weinberg equilibrium were also calculated. 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For these reasons, it has been a candidate gene in studies of the genetic basis of disease resistance and in population genetic analysis. South American native cattle breeds have been widely replaced by improved exotic breeds leading to a loss of genetic resources. In particular, South American native breeds have high levels of fertility and disease resistance. This work describes genetic variability in the BoLA-DRB3 gene in native (Caracu, Pantaneiro, Argentinean Creole) and exotic (Holstein, Jersey, Nelore, Gir) cattle breeds in Brazil and Argentina. PCR-RFLP alleles were identified by combining the restriction patterns for the BoLA-DRB3.2 locus obtained with RsaI, BstY and HaeIII restriction enzymes. Allelic frequencies and deviations from the Hardy-Weinberg equilibrium were also calculated. Analysis of the 24 BoLA-DRB3 PCR-RFLP alleles identified showed differences in the allele distributions among breeds.</description><subject>Alleles</subject><subject>Animals</subject><subject>Argentina</subject><subject>Bola-DRB3 gene</subject><subject>Bos</subject><subject>Brazil</subject><subject>Cattle</subject><subject>Cattle - genetics</subject><subject>Cattle - immunology</subject><subject>Disease resistance</subject><subject>DNA - genetics</subject><subject>DNA - isolation & purification</subject><subject>Exons</subject><subject>Fertility</subject><subject>Gene Frequency</subject><subject>Genetic diversity</subject><subject>Genetic resources</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>Immune response</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Species Specificity</subject><issn>0006-2928</issn><issn>1573-4927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkL1PwzAQxS0EoqUwsyGLAcEQ8NlxbbO1hQJSJFCBOXKTS5sqiUM-JPrfY0RZWFjudHq_e9J7hJwCuwbGxY29BQacs1Bzo024R4YglQhCw9U-GTLGxgE3XA_IUdtu_GlYGB6SAYCSWnE1JOsFtl2TJ13uKpo1dlVi1dECq1W3prUrtqVr6nXelvRyMY9ermheUfz0LKcuo90a6dRFk-BuMRV0hRV-66-u98-TEr2vrWhiu67AY3KQ2aLFk90ekff5_dvsMYieH55mkyhIhFJdkCIHk4QWDKSJDFH6oYyx1mIiuZDSCKNUBspazrTkoHUqExzDEiC1IMSIXPz41o376H24uMzbBIvCVuj6NlZcCOar-xcEDVxJAA-e_wE3rm8qHyL2LbKQaaE8dLaD-mWJaVw3eWmbbfzbtPgCcZ99JA</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Miretti, M M</creator><creator>Ferro, J A</creator><creator>Lara, M A</creator><creator>Contel, E P</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7SS</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>Restriction fragment length polymorphism (RFLP) in exon 2 of the BoLA-DRB3 gene in South American cattle</title><author>Miretti, M M ; 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| subjects | Alleles Animals Argentina Bola-DRB3 gene Bos Brazil Cattle Cattle - genetics Cattle - immunology Disease resistance DNA - genetics DNA - isolation & purification Exons Fertility Gene Frequency Genetic diversity Genetic resources Histocompatibility Antigens Class II - genetics Immune response Polymorphism, Restriction Fragment Length Species Specificity |
| title | Restriction fragment length polymorphism (RFLP) in exon 2 of the BoLA-DRB3 gene in South American cattle |
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