Influence of surface-modifying surfactants on the pharmacokinetic behavior of 14C-poly (methylmethacrylate) nanoparticles in experimental tumor models

The aim of this study was to investigate the different pharmacokinetic behavior of surface-modified poly(methylmethacrylate) (PMMA) nanoparticles. The particles were 14C-labeled and coated with polysorbate 80, poloxamer 407, and poloxamine 908. Plain particles served as control particles. In vivo st...

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Veröffentlicht in:	Pharmaceutical research 2001-11, Vol.18 (11), p.1613-1619
Hauptverfasser:	LODE, Jörg, FICHTNER, Iduna, KREUTER, Jörg, BERNDT, Antje, DIEDERICHS, Julia Eva, RESZKA, Regina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Area Under Curve Biological and medical sciences Blood-Brain Barrier Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Endothelial Growth Factors - biosynthesis Female General pharmacology Glioblastoma - drug therapy Glioblastoma - metabolism Glioblastoma - pathology Humans Immunohistochemistry Injections, Intravenous Lymphokines - biosynthesis Medical sciences Melanoma, Experimental - drug therapy Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Mice Mice, Nude Microspheres Neoplasm Transplantation Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymethyl Methacrylate - chemistry Polymethyl Methacrylate - pharmacokinetics Surface-Active Agents - chemistry Suspensions Tissue Distribution Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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