Heparin-binding EGF-like growth factor decreases inducible nitric oxide synthase and nitric oxide production after intestinal ischemia/reperfusion injury

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) has been shown to protect intestine from ischemia/reperfusion (I/R) injury in vivo and to down-regulate inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in intestinal epithelial cells in vitro. The present stu...

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Veröffentlicht in:	Antioxidants & redox signaling 2001-10, Vol.3 (5), p.919-930
Hauptverfasser:	Xia, G, Lara-Marquez, M, Luquette, M H, Glenn, S, Haque, A, Besner, G E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Down-Regulation Epidermal Growth Factor - chemistry Epidermal Growth Factor - metabolism Heparin-binding EGF-like Growth Factor Humans Immunohistochemistry Intercellular Signaling Peptides and Proteins Intestines - drug effects Luminescent Measurements Male Nitrates - blood Nitric Oxide - biosynthesis Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase Type II Nitrites - blood Rats Rats, Sprague-Dawley Recombinant Proteins - metabolism Reperfusion Injury Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism RNA, Ribosomal - metabolism Transcription, Genetic
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