Immunization with the C-Terminal Region of Trypanosoma cruzi Ribosomal P1 and P2 Proteins Induces Long-Term Duration Cross-Reactive Antibodies with Heart Functional and Structural Alterations in Young and Aged Mice

The R13 peptide sequence (EEEDDDMGFGLFD) that corresponds to the C-terminal region of Trypanosoma cruzi ribosomal P1 and P2 proteins differs from the eukariotic P concensus sequence EESDDDMGFGLFD (H13) only in a nonconservative amino acid substitution. The immunization of BALB/c mice with R13 synthe...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2000-11, Vol.97 (2), p.89-94
Hauptverfasser:	Motrán, Claudia C., Fretes, Ricardo E., Cerbán, Fabio M., Rivarola, Hector W., Vottero de Cima, Elsa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Antibodies, Protozoan - immunology Biological and medical sciences Cross Reactions - immunology Female Heart - physiology Human protozoal diseases Infectious diseases Medical sciences Mice Mice, Inbred BALB C Myocardium - pathology Parasitic diseases Protozoal diseases Protozoan Proteins - immunology ribosomal P1 protein ribosomal P2 protein ribosomal protein P1 ribosomal protein P2 Ribosomal Proteins - immunology Trypanosoma cruzi Trypanosomiasis
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